Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Staff Software Engineer, Java Backend
$120K - $170K *
Lead engineering efforts by writing production code and mentoring a team. Drive modernization initiatives through Java microservices while managing performance and growth of engineers. Collaborate wit...
Reposted 2 days ago
$175K - $210K *
Unlock potential by leading Revenue Operations to drive scalable growth. Collaborate with executives to develop strategies, oversee forecasting, and enhance commercial effectiveness through data-drive...
Reposted 2 days ago
$120K - $130K *
Unlock potential by leading the design and optimization of secure cloud-native platforms. Collaborate across teams to enhance software delivery, implement CI/CD pipelines, and drive best practices in...
2 days ago
Associate Director- Model Audit, Model Build and Transactions Advisory
$120K - $145K *
Drive excellence by leading model audits and mentoring a dynamic team. Collaborate on complex financial models, ensuring accuracy and strategic growth, while enhancing methodologies to deliver top-not...
Reposted 2 days ago
$150K - $220K *
Join a dynamic team as you drive customer success and retention for utility clients. Leverage your expertise to build strong relationships, execute strategic account plans, and elevate our mission in...
2 days ago
W2 or 1099 Option Available | $50,000 commencement bonus
$100K - $120K *
Empower patient care by administering anesthesia and supporting surgical teams. Collaborate with anesthesiologists and OR management to ensure safe, effective anesthesia practices across pre-operative...
2 days ago
Environmental Health and Safety Manager
$88K - $105K *
Champion safety and compliance by leading EHS initiatives, managing regulations, and fostering a secure workplace. Collaborate with teams to implement training and audits, ensuring a proactive approac...
2 days ago
$73K - $131K *
Drive analytics excellence by managing a team that transforms data into actionable insights, optimizing strategic decisions and enhancing operational efficiency across the business unit...
2 days ago
Project Manager, Senior (Remote)
$114K - $155K *
Champion project success by leading medium to large-scale healthcare and technology initiatives, ensuring timely delivery within scope and budget while fostering collaboration among stakeholders and m...
2 days ago
$95K - $115K *
Unlock your potential by providing expert advisory in complex debt solutions for commercial banking clients. Collaborate with teams to deliver integrated strategies, manage credit processes, and mento...
2 days ago
Corporate Communications Manager
$107K - $180K *
Manage and deliver strategic communications for litigation and regulatory matters. Collaborate with Legal and C-suite peers, ensuring alignment between legal strategy and public voice while leading cr...
Reposted 2 days ago
Senior Manager, Product Design (UI/Visual)
$186K - $314K *
Unlock your potential as a Senior Manager of Product Design, leading a team to refine visual identity and enhance customer experiences. Collaborate across teams to drive quality and innovation in digi...
2 days ago
$100K - $130K *
Elevate your career by leading impactful events that enhance visibility and engagement. Collaborate cross-functionally to develop strategic relationships and deliver high-quality experiences at confer...
2 days ago
Senior Software Engineer (Customer Success)
$120K - $145K *
Empower teams by building internal tools and automations to enhance support efficiency, diagnose issues, and collaborate with product and engineering for improved platform usability and customer exper...
2 days ago
$88K - $105K *
Lead the design and execution of complex structural systems, mentoring junior engineers while collaborating with multidisciplinary teams to ensure project success and adherence to deadlines...
2 days ago
$80K - $95K *
Engineer innovative solutions as a Project Engineer, overseeing diverse projects from design to execution. Collaborate with teams to ensure quality standards and effective communication, driving conti...
2 days ago
Clinical Research Associate/Sr. Clinical Research Associate - Western US - FSP
$85K - $100K *
Optimize clinical trial execution by managing site relationships, ensuring compliance, and safeguarding patient safety. Play a key role in monitoring, training, and resolving issues to enhance study q...
2 days ago
$175K - $210K *
Accelerate progress at joint ventures with health systems, leading complex transactions from engagement to execution. Drive growth through partnerships, leveraging strategic relationships and operatio...
2 days ago
Manager, Market Access and Reimbursement - Northeast
$136K - $170K *
Transform patient access by leading reimbursement initiatives and collaborating with cross-functional teams to maximize the reach of innovative healthcare technologies while ensuring compliance and ed...
Reposted 2 days ago
Associate Engineer - Infrastructure & Integrations Support
$73K - $91K *
Engage in operational support for enterprise infrastructure and integration applications. Utilize your expertise in Linux and Windows environments, scripting, and automation to enhance reliability and...
2 days ago
$88K - $102K *
Elevate your career by managing day-to-day financial operations, ensuring compliance, and supporting strategic financial initiatives. Collaborate with diverse teams to maintain financial health and dr...
Reposted 2 days ago
Specialist, Product Program Management
$85K - $95K *
Drive the end-to-end delivery of complex curriculum projects, collaborating across teams to ensure high-quality outcomes that meet business and learner needs while managing risks and stakeholder expec...
2 days ago
Health System Director - Base + Commission
$90K - $130K *
Drive strategic partnerships by leading the sales cycle for hospital systems. Engage C-suite executives to negotiate complex agreements, enhancing operational efficiency and revenue retention in wound...
2 days ago
AVP, Underwriting Consultant - Large Case
$136K - $185K *
Pioneer innovative underwriting solutions while building strong client relationships. Collaborate with teams to assess complex risks and provide strategic guidance, ensuring exceptional service and co...
2 days ago
$119K - $186K *
Lead the charge in delivering strategic legal counsel for complex corporate transactions, managing M&A processes globally, and ensuring effective collaboration across departments to drive business suc...
2 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.