Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Clinical Research Associate/Sr. Clinical Research Associate - Western US - FSP
$85K - $100K *
Optimize clinical trial execution by managing site relationships, ensuring compliance, and safeguarding patient safety. Play a key role in monitoring, training, and resolving issues to enhance study q...
Yesterday
$175K - $210K *
Accelerate progress at joint ventures with health systems, leading complex transactions from engagement to execution. Drive growth through partnerships, leveraging strategic relationships and operatio...
Yesterday
Manager, Market Access and Reimbursement - Northeast
$136K - $170K *
Transform patient access by leading reimbursement initiatives and collaborating with cross-functional teams to maximize the reach of innovative healthcare technologies while ensuring compliance and ed...
Reposted yesterday
Associate Engineer - Infrastructure & Integrations Support
$73K - $91K *
Engage in operational support for enterprise infrastructure and integration applications. Utilize your expertise in Linux and Windows environments, scripting, and automation to enhance reliability and...
Yesterday
$88K - $102K *
Elevate your career by managing day-to-day financial operations, ensuring compliance, and supporting strategic financial initiatives. Collaborate with diverse teams to maintain financial health and dr...
Reposted yesterday
Specialist, Product Program Management
$85K - $95K *
Drive the end-to-end delivery of complex curriculum projects, collaborating across teams to ensure high-quality outcomes that meet business and learner needs while managing risks and stakeholder expec...
Yesterday
Health System Director - Base + Commission
$90K - $130K *
Drive strategic partnerships by leading the sales cycle for hospital systems. Engage C-suite executives to negotiate complex agreements, enhancing operational efficiency and revenue retention in wound...
Yesterday
AVP, Underwriting Consultant - Large Case
$136K - $185K *
Pioneer innovative underwriting solutions while building strong client relationships. Collaborate with teams to assess complex risks and provide strategic guidance, ensuring exceptional service and co...
Yesterday
$119K - $186K *
Lead the charge in delivering strategic legal counsel for complex corporate transactions, managing M&A processes globally, and ensuring effective collaboration across departments to drive business suc...
Yesterday
Senior Advisor, Product Line Management, Implementation Services
$176K - $281K *
Empower your career by leading complex service portfolios, driving strategic initiatives, and delivering measurable value through innovative solutions in a dynamic environment. Collaborate across team...
Yesterday
Senior Transmission Line Engineer
$73K - $132K *
Grow your career with a dynamic team solving complex challenges in electric transmission design for high-voltage systems, ensuring compliance with industry standards and delivering impactful projects...
Yesterday
$108K - $130K *
Lead the charge in overseeing JPATS Flight Operations, managing flight crew scheduling, and ensuring compliance with aviation safety standards while driving program efficiency and effectiveness...
Yesterday
CrowdStrike Platform Sr. Resident Consultant - Cloud (Remote)
$100K - $155K *
Join a dynamic team to lead the deployment and support of cloud security solutions, ensuring optimal performance and customer satisfaction through expert technical guidance and strategic partnerships...
Yesterday
Director, Operations Readiness
$117K - $176K *
Drive the development and governance of enterprise processes, ensuring alignment across operations and technology. Lead initiatives that enhance operational excellence and foster adoption of standardi...
Yesterday
Senior Partner Marketing Manager
$116K - $189K *
Transform partner marketing strategies by developing data-driven co-marketing plans, driving pipeline growth, and aligning sales teams with partners. Collaborate to create impactful campaigns and mana...
Reposted yesterday
Production Planning Scheduling & Control Manager
$90K - $110K *
Join a team that's driving excellence in production planning and scheduling. Lead a dedicated group to optimize manufacturing processes, enhance operational efficiency, and ensure customer satisfactio...
Yesterday
$150K *
Shape the future of our organization by providing visionary leadership, strategic direction, and operational oversight to achieve mission-driven goals while fostering partnerships and ensuring fiscal...
Yesterday
$110K - $130K *
Accelerate progress at the forefront of digital transformation by managing complex data solutions. Collaborate with a global IT team to innovate and optimize SAP BW and BPC applications, driving effic...
Yesterday
Staff Product Manager, Retail Experiences
$165K - $195K *
Join us to define and drive the product vision for Retail Experiences, enhancing guest journeys through innovative digital solutions. Collaborate across teams to create impactful, user-centric product...
Reposted yesterday
Lead Systems Engineer - Workforce Applications - Microsoft
$110K - $130K *
Reimagine workforce productivity by leading strategic initiatives in Unified Communications. Drive innovation across Microsoft and Atlassian platforms, mentor engineers, and enhance collaboration to m...
Yesterday
Ellucian Colleague Accounts Receivable Consultant
$80K - $95K *
Take ownership of the Colleague Accounts Receivable solutions, collaborating with higher education clients to design, implement, and optimize systems while ensuring effective billing, payment processi...
Reposted yesterday
$80K - $95K *
Empower institutions by delivering tailored ERP solutions in financial aid, optimizing processes, and ensuring compliance. Collaborate with stakeholders to enhance student services and drive strategic...
Reposted yesterday
Claims Manager - Rental Vehicle Claims
$95K - $115K *
Drive the success of a dynamic claims team by leading, coaching, and optimizing performance. Ensure quality outcomes, manage client relationships, and execute strategic initiatives for continuous impr...
Yesterday
Claims Team Lead - Rental Vehicle Claims
$80K - $95K *
Transform the claims process by leading a team of adjusters, ensuring quality and efficiency while managing complex cases. Drive performance through coaching, feedback, and strategic oversight to meet...
Yesterday
$155K - $241K *
Join us to shape the future of platform engineering by driving strategic initiatives, influencing organizational architecture, and enhancing developer experience across a multi-cloud environment. Your...
Reposted yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.