Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Help us lead and innovate special services for PreK-12 students, ensuring compliance and effective support for diverse educational needs while fostering collaboration and growth across the district...

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$150K - $160K *

Empower enterprise customers by managing onboarding, adoption, and expansion strategies. Collaborate with sales and technical teams to ensure successful implementations and drive measurable outcomes f...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$108K - $147K *

Transform application development by leading a dynamic team to deliver innovative solutions, manage project priorities, and enhance collaboration across technical and business stakeholders in a fast-p...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $170K *

Transform the future of genomics by driving strategic partnerships and large-scale research projects with pharmaceutical and biotech companies. Leverage your extensive network to identify opportunitie...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform patient care as a vital pharmacist in a high-throughput environment. Collaborate with prescribers, verify prescriptions, and provide exceptional patient counseling to enhance outcomes and en...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$500K+*

Champion the growth of an Otolaryngology practice, leveraging strong patient demand and a collaborative network to deliver exceptional care while pursuing your clinical interests and expertise...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$150K - $180K *

Join a team that's launching a federal vertical, setting strategy, winning agency customers, and building a sales team. You'll lead initial pursuits, collaborate with key stakeholders, and shape our a...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Legal & Accounting

$95K - $115K *

Elevate program oversight by managing national compliance reviews and ensuring adherence to federal transit funding requirements. Utilize analytical skills to drive data-informed decisions and enhance...

Yesterday

  •   Less than 5 years exp.  •   Transportation

$80K - $95K *

Explore new opportunities as you drive sales growth in advanced wound care products across key healthcare sectors. Engage with clinicians and stakeholders to enhance patient outcomes while achieving p...

Kansas City, MORemote

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Transform enterprise communications by leading the design, deployment, and support of Cisco UC Manager and SBC platforms. Collaborate with cross-functional teams to enhance network infrastructure and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $150K *

Empower labor relations across diverse construction projects by fostering strong partnerships with unions and project teams. Ensure compliance with agreements and resolve employee relations issues to...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$175K - $210K *

Drive the enterprise data strategy and governance, ensuring data quality, compliance, and accessibility. Lead cross-functional teams to foster a data-rich culture, enabling advanced analytics and AI r...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Join a dynamic team as a Growth Copywriter, driving impactful messaging strategies through data-driven experimentation and empathetic communication to enhance women's health access and retention...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$83K - $124K *

Unlock insights and drive efficiency by providing analytical support to Business Development. Collaborate cross-functionally to enhance reporting, streamline processes, and ensure data integrity, empo...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$133K - $200K *

Accelerate clinical data management processes by leading data entry, ensuring quality, and overseeing database development for clinical trials. Collaborate with cross-functional teams to meet project...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$87K - $116K *

Join a team that's dedicated to guiding customers through their deployment journey, ensuring seamless transitions and successful outcomes. Leverage your expertise to manage complex projects and collab...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$144K - $206K *

Join a team that's shaping the future of event marketing by leading strategic initiatives, optimizing national events, and enhancing customer engagement through innovative programs and partnerships th...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Healthcare

$125K - $150K *

Lead the charge in optimizing healthcare payer systems by leveraging your expertise in Facets configuration and workflow analysis. Collaborate with cross-functional teams to design and implement scala...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Transform your career by assisting multi-state companies with state and local tax compliance, planning, and controversies. Collaborate with a dynamic team to deliver expert advice and build strong cli...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in outside sales by inspiring your team and building strong client relationships. Utilize your expertise to implement proven strategies, mentor new members, and drive growth while enjo...

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by leading a dynamic sales team, mentoring new talent, and driving business growth through relationship-building and tailored insurance solutions in a flexible, client-focused environ...

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$78K - $118K *

Transform operational analytics by creating impactful performance metrics, diagnosing trends, and collaborating with cross-functional teams to optimize claims processes and drive continuous improvemen...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Accelerate progress at driving new-business growth through strategic channel partnerships. This role involves managing partner relationships, executing sales strategies, and influencing outcomes to ac...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's driving revenue growth by managing strategic corporate healthcare accounts, optimizing client satisfaction, and delivering measurable outcomes through expert relationship-building a...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$92K - $138K *

Empower your career by leading accounts receivable operations, optimizing cash flow, and enhancing team performance. Drive strategic initiatives, ensure compliance, and collaborate cross-functionally...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.