Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $95K *

Explore new opportunities as you drive sales growth in advanced wound care products across key healthcare sectors. Engage with clinicians and stakeholders to enhance patient outcomes while achieving p...

Kansas City, MORemote

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Transform enterprise communications by leading the design, deployment, and support of Cisco UC Manager and SBC platforms. Collaborate with cross-functional teams to enhance network infrastructure and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $150K *

Empower labor relations across diverse construction projects by fostering strong partnerships with unions and project teams. Ensure compliance with agreements and resolve employee relations issues to...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$175K - $210K *

Drive the enterprise data strategy and governance, ensuring data quality, compliance, and accessibility. Lead cross-functional teams to foster a data-rich culture, enabling advanced analytics and AI r...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Join a dynamic team as a Growth Copywriter, driving impactful messaging strategies through data-driven experimentation and empathetic communication to enhance women's health access and retention...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$83K - $124K *

Unlock insights and drive efficiency by providing analytical support to Business Development. Collaborate cross-functionally to enhance reporting, streamline processes, and ensure data integrity, empo...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$133K - $200K *

Accelerate clinical data management processes by leading data entry, ensuring quality, and overseeing database development for clinical trials. Collaborate with cross-functional teams to meet project...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$87K - $116K *

Join a team that's dedicated to guiding customers through their deployment journey, ensuring seamless transitions and successful outcomes. Leverage your expertise to manage complex projects and collab...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$144K - $206K *

Join a team that's shaping the future of event marketing by leading strategic initiatives, optimizing national events, and enhancing customer engagement through innovative programs and partnerships th...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Healthcare

$125K - $150K *

Lead the charge in optimizing healthcare payer systems by leveraging your expertise in Facets configuration and workflow analysis. Collaborate with cross-functional teams to design and implement scala...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Transform your career by assisting multi-state companies with state and local tax compliance, planning, and controversies. Collaborate with a dynamic team to deliver expert advice and build strong cli...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in outside sales by inspiring your team and building strong client relationships. Utilize your expertise to implement proven strategies, mentor new members, and drive growth while enjo...

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by leading a dynamic sales team, mentoring new talent, and driving business growth through relationship-building and tailored insurance solutions in a flexible, client-focused environ...

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$78K - $118K *

Transform operational analytics by creating impactful performance metrics, diagnosing trends, and collaborating with cross-functional teams to optimize claims processes and drive continuous improvemen...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Accelerate progress at driving new-business growth through strategic channel partnerships. This role involves managing partner relationships, executing sales strategies, and influencing outcomes to ac...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's driving revenue growth by managing strategic corporate healthcare accounts, optimizing client satisfaction, and delivering measurable outcomes through expert relationship-building a...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$92K - $138K *

Empower your career by leading accounts receivable operations, optimizing cash flow, and enhancing team performance. Drive strategic initiatives, ensure compliance, and collaborate cross-functionally...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Advance your career by driving sales strategies in the pharmaceutical sector. Engage with healthcare professionals to deliver impactful presentations and optimize customer relationships while achievin...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in managing complex technical projects across IT, Security, and Compliance. Engage with customers to translate technical needs into actionable plans while ensuring seamless internal co...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $155K *

Lead the charge in managing and expanding environmental investigation and remediation projects, ensuring technical excellence, client satisfaction, and regulatory compliance while fostering strong cli...

Yesterday

  •   5 - 7 years exp.  •   Technical Services

$110K - $166K *

Lead the clinical data management process, ensuring quality and compliance from study startup to database lock. Collaborate with teams to develop databases, oversee data integrity, and train personnel...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$133K - $200K *

Drive excellence in clinical data management by overseeing data processes, ensuring quality, and leading cross-functional teams to deliver timely and accurate results throughout the clinical trial lif...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Reimagine higher education processes by leveraging your expertise in Ellucian Colleague Registration and Records. Collaborate with institutions to enhance student enrollment services and optimize work...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$138K - $171K *

Transform procurement strategies and supply chain solutions to meet customer needs. Lead negotiations, ensure compliance, and drive organizational improvements while collaborating with stakeholders to...

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$90K - $110K *

Drive success by partnering with colleges to optimize their Ellucian Colleague ERP systems, ensuring effective application design, configuration, and support while adhering to client budgets and timel...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.