Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $95K *

Elevate your career by driving sales growth in the Advanced Wound Care market. Manage key accounts and foster relationships with healthcare professionals to enhance product adoption and meet sales tar...

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$131K - $209K *

Engage with teams to deliver comprehensive AI enablement programs, designing tailored learning paths and fostering a culture of proficiency across all departments. Collaborate closely with HR to integ...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Build strategic partnerships and drive growth in distribution channels across North America. Focus on relationship management, revenue growth, and channel enablement to enhance business performance an...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Energy & Utilities

$125K - $150K *

Support site leadership by spearheading financial strategies and governance, managing a high-performing finance team, and ensuring compliance while driving insightful analysis and operational efficien...

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$168K - $280K *

Optimize financial planning and analysis processes, driving strategic initiatives and enhancing reporting capabilities. Collaborate with leadership to deliver insights that support company-wide alignm...

RemoteRemote

Yesterday

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$268K - $368K *

Unlock potential by leading global labeling strategy and operations, ensuring compliance and alignment across product lifecycles. Collaborate with cross-functional teams to drive effective labeling ne...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$83K - $107K *

Join a dynamic team to enhance patient care through interdisciplinary collaboration, psychosocial assessments, and resource development. Lead initiatives that empower families and improve health outco...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$190K - $305K *

Join a team that's shaping healthcare by providing legal guidance on regulatory matters, employee benefits, and AI initiatives. As a senior contributor, you'll lead complex reviews, manage risks, and...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$162K - $192K *

Lead strategic sales initiatives and manage P&L for MCC, driving growth through vendor contracts and financial oversight while executing the Commercial Strategic Plan and ensuring alignment with site...

Yesterday

  •   8 - 10 years exp.  •   Food & Beverages

$155K - $170K *

Lead the charge in shaping enterprise business solutions through hands-on architecture and delivery in Microsoft Dynamics 365 Finance & Operations, focusing on integration, process optimization, and o...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Staffing

$140K - $150K *

Lead the charge in nationwide Cybersecurity Disaster Recovery and Contingency Planning initiatives, providing strategic oversight and technical expertise to enhance organizational resilience and ensur...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Staffing

$105K - $127K *

Champion transformative patient experience strategies by leveraging data insights to drive high-impact initiatives. Collaborate with C-suite executives and healthcare providers to enhance operational...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the development of enterprise-grade applications using Java, Python, and AI technologies. Collaborate with cross-functional teams to design and implement robust software solutions in a dynamic, A...

Yesterday

  •   5 - 7 years exp.  •   Staffing

$183K - $190K *

Unlock your potential by leading SAP GTS projects, designing solutions, and driving customer success. Collaborate with teams to deliver innovative implementations and enhance business processes while...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $190K *

Lead the charge in ensuring compliance for medical devices by managing audits, reviewing documentation, and collaborating with clients. Utilize your expertise in regulatory frameworks to drive quality...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Technical Services

$185K - $215K *

Take ownership of analytical development initiatives, ensuring compliance, accuracy, and high-quality documentation for multiple projects. Collaborate closely with internal teams and external partners...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $250K *

Take ownership of comprehensive fraud risk management across consumer and small business segments. Lead detection frameworks, analyze fraud patterns, and collaborate cross-functionally to enhance prod...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $225K *

Transform the claims process by building robust event-driven systems. As a key player, you'll design, implement, and maintain backend services, ensuring reliability and efficiency while mentoring fell...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$160K - $220K *

Optimize market operations by managing risk and ensuring compliance in trade processes. You'll monitor performance, resolve client issues, and drive operational improvements to safeguard trading integ...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $123K *

Lead the charge in pharmaceutical meetings operations, driving client partnerships and operational excellence while navigating compliance. Shape processes and enhance stakeholder engagement to deliver...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Transportation

$180K - $220K *

Transform enterprise AI partnerships by leading strategic growth initiatives, enhancing relationships, and driving revenue across key Google organizations. Leverage your expertise in AI, cloud, and di...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Drive innovative experiential solutions by leading creative teams to design impactful business events. Collaborate with clients to craft engaging experiences that align with strategic objectives, ensu...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Champion strategic partnerships and drive revenue growth through effective channel management and collaborative business planning, ensuring sales success and partner satisfaction while navigating comp...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$120K - $247K *

Unlock potential by leading complex digital production across diverse platforms, ensuring seamless execution of business and creative strategies. Collaborate with cross-functional teams to deliver imp...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$96K - $166K *

Lead the enhancement and scaling of Adobe Experience Platform solutions, ensuring optimal data governance and architecture across digital ecosystems. Collaborate with cross-functional teams to achieve...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.