Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$105K - $110K *

Drive innovation as a Software Engineer III, enhancing full-stack capabilities and mentoring junior developers while collaborating with stakeholders to improve engineering processes and deliver impact...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Join a dynamic team as a Strategic Sales Engineer, driving sales growth through technical expertise and collaboration. Engage with sales leadership to create opportunities and deliver solutions across...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$117K - $195K *

Transform data into actionable insights by leveraging advanced analytics and visualization techniques. Collaborate with a dynamic team to support federal clients through data mining, preparation, and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$70K - $205K *

Drive innovative strategies and solutions for digital laboratory operations, enhancing scientific intelligence and user experiences while collaborating with clients to transform their laboratory envir...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Lead the charge in delivering innovative technology solutions across diverse sectors. Collaborate with clients to enhance systems in aerospace, finance, and healthcare, ensuring excellence from discov...

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Lead and enhance employee engagement initiatives, ensuring compliance and performance excellence. Collaborate with leadership to foster a supportive culture, optimize onboarding, and drive retention s...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Join a team that's dedicated to delivering high-quality inpatient care for pediatric patients. Utilize advanced skills to assess, diagnose, and treat children in a collaborative environment, ensuring...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Elevate supply chain operations by leading multiple departments, managing budgets, and driving continuous improvement initiatives to optimize efficiency and service levels across the hospital's supply...

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Elevate your career by designing and optimizing data pipelines and infrastructure. Contribute to large-scale data systems that support critical agency missions, ensuring efficiency and security across...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Join us to innovate and develop cutting-edge software solutions, applying your technical skills in a dynamic environment while collaborating with experienced engineers on challenging projects that imp...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Unlock potential by designing and optimizing data pipelines and infrastructure to support large datasets. Collaborate with cross-functional teams to enhance data delivery and ensure efficient, secure...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Optimize commercialization strategies for large-scale power solutions, focusing on data centers and hyperscalers. Lead deal origination, negotiate agreements, and collaborate with senior leaders to dr...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Energy & Utilities

$100K - $152K *

Engage in leading utility-scale power-system projects, overseeing all phases from planning to execution. Collaborate with multidisciplinary teams to ensure project delivery aligns with client expectat...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Technical Services

$90K - $110K *

Collaborate with cross-functional teams to manage the full contract lifecycle, ensuring compliance and risk mitigation while negotiating agreements that align with business objectives and protect comp...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Join a dynamic team as you drive revenue growth through virtual Finance & Insurance sales. Lead the full sales process, enhance customer experiences, and achieve performance targets in a fast-paced, r...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$108K - $130K *

Transform enterprise web application security by engineering and managing F5 WAF policies. Collaborate with cybersecurity teams to enhance protection, tune policies, and respond to incidents, ensuring...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Transform patient access to specialty medications by leading implementation projects, optimizing workflows, and collaborating with clinical teams to enhance pharmacy experiences and resolve issues eff...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$126K - $188K *

Unlock the potential of cybersecurity by leading risk management initiatives, enhancing security operations, and driving impactful projects. Collaborate globally to develop automation and metrics that...

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$106K - $284K *

Lead the charge in designing and delivering secure, scalable microservices that enhance healthcare data exchange. Collaborate with cross-functional teams to ensure compliance and operational excellenc...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Grow your career with a dynamic role overseeing construction projects, ensuring compliance with specifications and budgets. Lead inspections, manage contracts, and coordinate teams on diverse projects...

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$54K - $145K *

Unlock potential by collaborating with cross-functional teams to deliver impactful analysis and requirements for Medicare and Medicaid enrollment solutions within an Agile framework, ensuring seamless...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$183K - $200K *

Shape the future of offensive security by leading advanced penetration testing, red-team engagements, and AI-assisted workflows. Collaborate with cross-functional teams to enhance security measures an...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Consumer Technology

$80K - $95K *

Take ownership of external financial reporting by preparing and consolidating quarterly statements, ensuring GAAP compliance, and enhancing reporting initiatives. Collaborate with leadership to delive...

Yesterday

  •   Less than 5 years exp.  •   Transportation

$80K - $95K *

Transform building performance by conducting assessments and energy audits for diverse properties. Analyze systems, develop recommendations, and prepare reports to enhance efficiency and sustainabilit...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$145K - $175K *

Empower organizations to transform workflows with AI by architecting solutions that integrate Grok Build and Grok Bot. Collaborate with engineering teams and executives to drive adoption and optimize...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.