Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Software Engineer III - Full Stack (Drupal)
$105K - $110K *
Drive innovation as a Software Engineer III, enhancing full-stack capabilities and mentoring junior developers while collaborating with stakeholders to improve engineering processes and deliver impact...
Reposted yesterday
$110K - $130K *
Join a dynamic team as a Strategic Sales Engineer, driving sales growth through technical expertise and collaboration. Engage with sales leadership to create opportunities and deliver solutions across...
Reposted yesterday
$117K - $195K *
Transform data into actionable insights by leveraging advanced analytics and visualization techniques. Collaborate with a dynamic team to support federal clients through data mining, preparation, and...
Yesterday
Consultant, Scientific and Laboratory Informatics
$70K - $205K *
Drive innovative strategies and solutions for digital laboratory operations, enhancing scientific intelligence and user experiences while collaborating with clients to transform their laboratory envir...
Yesterday
$100K - $120K *
Lead the charge in delivering innovative technology solutions across diverse sectors. Collaborate with clients to enhance systems in aerospace, finance, and healthcare, ensuring excellence from discov...
Yesterday
Vice President of Culture and Engagement KS and MO Region
$110K - $130K *
Lead and enhance employee engagement initiatives, ensuring compliance and performance excellence. Collaborate with leadership to foster a supportive culture, optimize onboarding, and drive retention s...
Yesterday
Pediatric Advanced Practice Provider - Hospitalist
$95K - $115K *
Join a team that's dedicated to delivering high-quality inpatient care for pediatric patients. Utilize advanced skills to assess, diagnose, and treat children in a collaborative environment, ensuring...
Yesterday
$95K - $115K *
Elevate supply chain operations by leading multiple departments, managing budgets, and driving continuous improvement initiatives to optimize efficiency and service levels across the hospital's supply...
Reposted yesterday
$95K - $115K *
Elevate your career by designing and optimizing data pipelines and infrastructure. Contribute to large-scale data systems that support critical agency missions, ensuring efficiency and security across...
Yesterday
$80K - $95K *
Join us to innovate and develop cutting-edge software solutions, applying your technical skills in a dynamic environment while collaborating with experienced engineers on challenging projects that imp...
Reposted yesterday
$95K - $115K *
Unlock potential by designing and optimizing data pipelines and infrastructure to support large datasets. Collaborate with cross-functional teams to enhance data delivery and ensure efficient, secure...
Yesterday
WattBridge -Commercial, Director
$150K - $180K *
Optimize commercialization strategies for large-scale power solutions, focusing on data centers and hyperscalers. Lead deal origination, negotiate agreements, and collaborate with senior leaders to dr...
Yesterday
Project Manager 1 - Substation (STATCOM)
$100K - $152K *
Engage in leading utility-scale power-system projects, overseeing all phases from planning to execution. Collaborate with multidisciplinary teams to ensure project delivery aligns with client expectat...
Yesterday
$90K - $110K *
Collaborate with cross-functional teams to manage the full contract lifecycle, ensuring compliance and risk mitigation while negotiating agreements that align with business objectives and protect comp...
Yesterday
Remote Finance & Insurance Manager
$80K - $95K *
Join a dynamic team as you drive revenue growth through virtual Finance & Insurance sales. Lead the full sales process, enhance customer experiences, and achieve performance targets in a fast-paced, r...
Yesterday
F5 Advanced Web Application Firewall Engineer
$108K - $130K *
Transform enterprise web application security by engineering and managing F5 WAF policies. Collaborate with cybersecurity teams to enhance protection, tune policies, and respond to incidents, ensuring...
Yesterday
Shared Services Project Manager
$80K - $95K *
Transform patient access to specialty medications by leading implementation projects, optimizing workflows, and collaborating with clinical teams to enhance pharmacy experiences and resolve issues eff...
Yesterday
Principal Incident Response Engineer
$126K - $188K *
Unlock the potential of cybersecurity by leading risk management initiatives, enhancing security operations, and driving impactful projects. Collaborate globally to develop automation and metrics that...
Yesterday
Staff Software Development Engineer
$106K - $284K *
Lead the charge in designing and delivering secure, scalable microservices that enhance healthcare data exchange. Collaborate with cross-functional teams to ensure compliance and operational excellenc...
Yesterday
$80K - $95K *
Grow your career with a dynamic role overseeing construction projects, ensuring compliance with specifications and budgets. Lead inspections, manage contracts, and coordinate teams on diverse projects...
Yesterday
Pharmacy Eligibility/Claims Business Analyst
$54K - $145K *
Unlock potential by collaborating with cross-functional teams to deliver impactful analysis and requirements for Medicare and Medicaid enrollment solutions within an Agile framework, ensuring seamless...
Reposted yesterday
Principal Offensive Security Engineer
$183K - $200K *
Shape the future of offensive security by leading advanced penetration testing, red-team engagements, and AI-assisted workflows. Collaborate with cross-functional teams to enhance security measures an...
Yesterday
Senior External Reporting Accountant
$80K - $95K *
Take ownership of external financial reporting by preparing and consolidating quarterly statements, ensuring GAAP compliance, and enhancing reporting initiatives. Collaborate with leadership to delive...
Yesterday
Lead Project Assessor - Energy
$80K - $95K *
Transform building performance by conducting assessments and energy audits for diverse properties. Analyze systems, develop recommendations, and prepare reports to enhance efficiency and sustainabilit...
Yesterday
$145K - $175K *
Empower organizations to transform workflows with AI by architecting solutions that integrate Grok Build and Grok Bot. Collaborate with engineering teams and executives to drive adoption and optimize...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.