Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$90K - $105K *

Elevate strategic communications for vaccine development, translating complex science into engaging narratives for diverse audiences while managing multiple priorities in a dynamic global health envir...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $250K *

Transform the GTM landscape by leading strategic initiatives, aligning teams, and driving measurable outcomes across solution areas. Foster collaboration and innovation to enhance sales processes and...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$77K - $202K *

Transform healthcare operations by analyzing processes, implementing solutions, and guiding teams. Collaborate with clients to enhance efficiency and align technology with business goals while mentori...

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$77K - $202K *

Transform healthcare provider operations by analyzing processes, implementing software solutions, and guiding teams. Leverage critical thinking to enhance efficiency and build strong client relationsh...

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$124K - $158K *

Transform patient care by leading pharmacy operations, ensuring safe dispensing, and fostering a culture of excellence. Collaborate with the pharmacy team to enhance patient experiences and support he...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower transformative telehealth solutions by designing and implementing robust software infrastructure. Join a dynamic team to innovate, automate, and streamline applications, impacting the healthca...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$66K - $111K *

Join a team that's dedicated to enhancing provider experiences through effective accounts receivable management. Collaborate with key stakeholders to drive strategic improvements, ensuring timely clai...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$66K - $111K *

Engage with healthcare providers to enhance accounts receivable management, ensuring timely claims administration and strategic planning. Collaborate with teams to resolve issues, improve service leve...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Elevate your career by leading strategic initiatives in enterprise systems. Drive operational excellence, enhance data integration, and champion modern processes to support institutional priorities an...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$153K - $171K *

Join a dynamic team to orchestrate complex technical programs, driving alignment and clarity across product and engineering. Empower teams to deliver impactful outcomes while leveraging AI insights fo...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Unlock potential by leading operational excellence across Engineering teams, ensuring timely delivery and adherence to standards. Collaborate with cross-functional teams to drive accountability and en...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Shape the future of cybersecurity in higher education by delivering expert assessments, advisory services, and tailored remediation plans that empower institutions to enhance their security posture an...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$115K - $135K *

Lead the charge in developing high-quality software solutions, mentoring engineers, and driving process improvements. Collaborate with stakeholders to enhance systems and deliver impactful results in...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$200K - $250K *

Join us in shaping technical strategies and growth initiatives for federal opportunities. Collaborate across teams to develop compelling solutions that drive success in complex pursuits, ensuring alig...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$105K - $110K *

Drive innovation as a Software Engineer III, enhancing full-stack capabilities and mentoring junior developers while collaborating with stakeholders to improve engineering processes and deliver impact...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Join a dynamic team as a Strategic Sales Engineer, driving sales growth through technical expertise and collaboration. Engage with sales leadership to create opportunities and deliver solutions across...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$117K - $195K *

Transform data into actionable insights by leveraging advanced analytics and visualization techniques. Collaborate with a dynamic team to support federal clients through data mining, preparation, and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$70K - $205K *

Drive innovative strategies and solutions for digital laboratory operations, enhancing scientific intelligence and user experiences while collaborating with clients to transform their laboratory envir...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Lead the charge in delivering innovative technology solutions across diverse sectors. Collaborate with clients to enhance systems in aerospace, finance, and healthcare, ensuring excellence from discov...

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Lead and enhance employee engagement initiatives, ensuring compliance and performance excellence. Collaborate with leadership to foster a supportive culture, optimize onboarding, and drive retention s...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Join a team that's dedicated to delivering high-quality inpatient care for pediatric patients. Utilize advanced skills to assess, diagnose, and treat children in a collaborative environment, ensuring...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Elevate supply chain operations by leading multiple departments, managing budgets, and driving continuous improvement initiatives to optimize efficiency and service levels across the hospital's supply...

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Elevate your career by designing and optimizing data pipelines and infrastructure. Contribute to large-scale data systems that support critical agency missions, ensuring efficiency and security across...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Join us to innovate and develop cutting-edge software solutions, applying your technical skills in a dynamic environment while collaborating with experienced engineers on challenging projects that imp...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Unlock potential by designing and optimizing data pipelines and infrastructure to support large datasets. Collaborate with cross-functional teams to enhance data delivery and ensure efficient, secure...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.