Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$125K - $155K *
Lead the charge in managing and expanding environmental investigation and remediation projects, ensuring technical excellence, client satisfaction, and regulatory compliance while fostering strong cli...
Yesterday
$110K - $166K *
Lead the clinical data management process, ensuring quality and compliance from study startup to database lock. Collaborate with teams to develop databases, oversee data integrity, and train personnel...
Yesterday
$133K - $200K *
Drive excellence in clinical data management by overseeing data processes, ensuring quality, and leading cross-functional teams to deliver timely and accurate results throughout the clinical trial lif...
Yesterday
Ellucian Colleague Registration & Records Consultant
$80K - $95K *
Reimagine higher education processes by leveraging your expertise in Ellucian Colleague Registration and Records. Collaborate with institutions to enhance student enrollment services and optimize work...
Reposted yesterday
$138K - $171K *
Transform procurement strategies and supply chain solutions to meet customer needs. Lead negotiations, ensure compliance, and drive organizational improvements while collaborating with stakeholders to...
Yesterday
$90K - $110K *
Drive success by partnering with colleges to optimize their Ellucian Colleague ERP systems, ensuring effective application design, configuration, and support while adhering to client budgets and timel...
Reposted yesterday
$200K - $240K *
Innovate the future of legal support in a fast-paced environment, managing key commercial agreements and navigating regulatory challenges across various sectors. You'll drive legal strategy, enhance i...
Reposted yesterday
Director, Security Compliance and Trust
$225K - $305K *
Create a robust security compliance program that ensures customer trust and regulatory readiness. Lead a global team, design controls, manage audits, and integrate AI-driven solutions to address diver...
Reposted yesterday
Senior Product Designer, Design Systems
$120K - $145K *
Champion the design systems for institutional and consumer products, ensuring precision and accessibility. Collaborate closely with engineers to deliver high-quality components and documentation, driv...
Yesterday
$165K - $297K *
Drive strategic growth by leading capture efforts for large federal contracts. Collaborate with senior leaders to develop winning strategies and engage clients effectively. This remote role requires s...
Yesterday
Ecosystem Sales Lead - Frontier AI
$150K - $180K *
Join a dynamic team to drive channel sales and co-sell strategies with leading AI partners. Leverage your expertise to build relationships, identify opportunities, and lead teams to close deals, all w...
Yesterday
Financial & Budget Management Analyst - Senior
$142K - $171K *
Elevate financial management practices and provide expert analysis, supporting program budgets and resource allocation with strategic insights and effective communication to key stakeholders in a comp...
Reposted yesterday
Product Marketing Manager, Release Marketer
$110K - $130K *
Execute go-to-market strategies for product releases, translating technical features into compelling narratives. Collaborate with cross-functional teams to enhance customer engagement and maintain hig...
Yesterday
Business Development Manager Data Centers, Network and IT Closets - West Region
$150K - $170K *
Transform business growth by developing strategic partnerships and driving sales in IT infrastructure. Leverage your expertise to build relationships, conduct market analysis, and exceed revenue targe...
Yesterday
Associate Director - Third Party Risk Management
$118K - $197K *
Accelerate progress at our Third Party Risk Management team by leading initiatives, enhancing governance, and collaborating across functions to drive effective risk management strategies and performan...
Yesterday
Associate Director - Third Party Risk Management
$118K - $197K *
Lead the charge in executing a robust Third Party Risk Management program, driving governance, oversight, and collaboration across teams to enhance risk management effectiveness and performance throug...
Yesterday
$160K - $200K *
Accelerate revenue growth by engaging Managed Service Providers, leading the full sales cycle, and building strong partnerships to drive NodeZero adoption and deliver compelling business solutions in...
Yesterday
Auditing & Education Consultant - IP Facility
$80K - $95K *
Join a team that's dedicated to enhancing coding accuracy through comprehensive audits and educational support. Leverage your expertise in ICD-10, CPT, and HCPCS coding to drive compliance and improve...
Yesterday
Network Engineer, Network Management
$80K - $95K *
Join a team that's dedicated to providing 24x7 operational support for DDI & Remote Access VPN services, ensuring high availability and exceptional customer service across a global infrastructure. Enh...
Yesterday
Network Engineer, Network Management
$80K - $95K *
Support our Network Security Services team by providing 24x7 operational assistance for DDI & Remote Access VPN, ensuring high availability and exceptional customer service across global infrastructur...
Yesterday
Neurosurgery - Nurse Practitioner APN
$95K - $115K *
Drive comprehensive neurosurgical care for Veterans, collaborating with specialists to provide advanced assessments, treatment plans, and ongoing management in both outpatient and inpatient settings...
Yesterday
Stonehaven - Director of Underwriting
$250K - $350K *
Transform your career by leading underwriting strategy and oversight. Supervise managers, enforce guidelines, and drive quality across all programs, ensuring a robust underwriting framework and risk m...
Reposted yesterday
Director, Strategic Initiatives
$134K - $249K *
Champion high-impact strategic initiatives that drive Provider Data Operations. Lead cross-functional teams, navigate complexities, and ensure measurable outcomes through effective execution and stake...
Yesterday
$110K - $130K *
Drive the design and execution of large-scale data centers, managing complex projects from initiation to construction. Oversee integrated schedules and governance, ensuring accountability while enabli...
Reposted yesterday
$80K - $95K *
Unlock potential by managing equity and option orders, ensuring compliance and best execution. Collaborate with trading desk teams to enhance order flow efficiency and address technology issues in a f...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.