Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Clinical Validation Audit (CVA) Trainer
$75K - $107K *
Unlock potential by delivering impactful training experiences that enhance audit quality and accuracy. Collaborate with clinical experts to translate complex guidelines into engaging learning material...
Yesterday
Senior Manager - Data Mining & Exploratory Intelligence
$93K - $154K *
Transform claims analysis by leveraging deep operational insights to identify patterns and anomalies. Collaborate with cross-functional teams to develop advanced data mining capabilities that enhance...
Yesterday
MDS Coordinator (RN) - Lenoir Woods, Full Time
$76K - $123K *
Optimize resident care by leading the MDS process, ensuring compliance with regulations, and collaborating with the interdisciplinary team to enhance quality outcomes and care plans for residents in a...
Yesterday
Registered Nurse (RN) - Breeze Park, FT Day/Evening
$64K - $103K *
Champion quality care by leveraging your nursing expertise to assess, coordinate, and deliver comprehensive services for residents, ensuring their physical and psychosocial needs are met within a coll...
Yesterday
Evening Nursing Supervisor (RN) - Lenoir Woods, FT Evenings
$74K - $118K *
Elevate nursing care standards by overseeing staff and ensuring compliance with regulations. Lead daily operations, support resident care, and foster a safe environment while maintaining high-quality...
Yesterday
Community Clinical Educator (RN) - Lenoir Woods, Full Time
$76K - $123K *
Lead the charge in clinical education by coordinating training programs, evaluating needs, and ensuring compliance with standards for clinical care team members across multiple sites, fostering a cult...
Yesterday
$80K - $95K *
Elevate your career by driving sales growth in the Advanced Wound Care market. Manage key accounts and foster relationships with healthcare professionals to enhance product adoption and meet sales tar...
Yesterday
$131K - $209K *
Engage with teams to deliver comprehensive AI enablement programs, designing tailored learning paths and fostering a culture of proficiency across all departments. Collaborate closely with HR to integ...
Reposted yesterday
Key Account Manager- Distribution
$80K - $95K *
Build strategic partnerships and drive growth in distribution channels across North America. Focus on relationship management, revenue growth, and channel enablement to enhance business performance an...
Yesterday
$125K - $150K *
Support site leadership by spearheading financial strategies and governance, managing a high-performing finance team, and ensuring compliance while driving insightful analysis and operational efficien...
Reposted yesterday
Director, Corporate Financial Planning & Analysis
$168K - $280K *
Optimize financial planning and analysis processes, driving strategic initiatives and enhancing reporting capabilities. Collaborate with leadership to deliver insights that support company-wide alignm...
Yesterday
Sr. Dir. Regulatory Affairs, Head of Global Labeling and Labeling Operations
$268K - $368K *
Unlock potential by leading global labeling strategy and operations, ensuring compliance and alignment across product lifecycles. Collaborate with cross-functional teams to drive effective labeling ne...
Yesterday
LEAD COORDINATOR SOCIAL WORK-OHIORISE
$83K - $107K *
Join a dynamic team to enhance patient care through interdisciplinary collaboration, psychosocial assessments, and resource development. Lead initiatives that empower families and improve health outco...
Yesterday
$190K - $305K *
Join a team that's shaping healthcare by providing legal guidance on regulatory matters, employee benefits, and AI initiatives. As a senior contributor, you'll lead complex reviews, manage risks, and...
Yesterday
Vice President, MCC Sales and Strategy
$162K - $192K *
Lead strategic sales initiatives and manage P&L for MCC, driving growth through vendor contracts and financial oversight while executing the Commercial Strategic Plan and ensuring alignment with site...
Yesterday
Director, Business Systems & Solution Architecture (D365 F&O)
$155K - $170K *
Lead the charge in shaping enterprise business solutions through hands-on architecture and delivery in Microsoft Dynamics 365 Finance & Operations, focusing on integration, process optimization, and o...
Reposted yesterday
Senior Cybersecurity Disaster Recovery & Contingency Planning SME
$140K - $150K *
Lead the charge in nationwide Cybersecurity Disaster Recovery and Contingency Planning initiatives, providing strategic oversight and technical expertise to enhance organizational resilience and ensur...
Reposted yesterday
Consultant, Patient Experience
$105K - $127K *
Champion transformative patient experience strategies by leveraging data insights to drive high-impact initiatives. Collaborate with C-suite executives and healthcare providers to enhance operational...
Reposted yesterday
Software Engineer, Java/Python & AI
$150K - $180K *
Lead the development of enterprise-grade applications using Java, Python, and AI technologies. Collaborate with cross-functional teams to design and implement robust software solutions in a dynamic, A...
Yesterday
SAP GTS Consultant (Multiple Positions Available)
$183K - $190K *
Unlock your potential by leading SAP GTS projects, designing solutions, and driving customer success. Collaborate with teams to deliver innovative implementations and enhance business processes while...
Yesterday
Project Manager I - Medical Devices
$120K - $190K *
Lead the charge in ensuring compliance for medical devices by managing audits, reviewing documentation, and collaborating with clients. Utilize your expertise in regulatory frameworks to drive quality...
Yesterday
Associate Director, Analytical Development
$185K - $215K *
Take ownership of analytical development initiatives, ensuring compliance, accuracy, and high-quality documentation for multiple projects. Collaborate closely with internal teams and external partners...
Reposted yesterday
Director of Fraud Risk Management (copy)
$150K - $250K *
Take ownership of comprehensive fraud risk management across consumer and small business segments. Lead detection frameworks, analyze fraud patterns, and collaborate cross-functionally to enhance prod...
Yesterday
Senior Software Engineer (CCC Auto / Agentic)
$180K - $225K *
Transform the claims process by building robust event-driven systems. As a key player, you'll design, implement, and maintain backend services, ensuring reliability and efficiency while mentoring fell...
Yesterday
$160K - $220K *
Optimize market operations by managing risk and ensuring compliance in trade processes. You'll monitor performance, resolve client issues, and drive operational improvements to safeguard trading integ...
Reposted yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.