Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$135K - $160K *

Lead enterprise architecture strategy across Oracle CX, ERP, HCM, and SCM Cloud. Collaborate with stakeholders to develop scalable solutions, ensuring alignment with business capabilities and technolo...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Staffing

$125K - $150K *

Unlock potential by managing client relationships and driving project success. You'll proactively address issues, identify growth opportunities, and ensure delivery excellence while fostering strong p...

United StatesRemote

Reposted yesterday

  •   15+ years exp.  •   Staffing

$95K - $115K *

Unlock your potential as a Data Engineer, driving innovative data solutions and optimizing data pipelines. Collaborate with cross-functional teams to enhance data quality and support analytics initiat...

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$92K - $136K *

Help us drive customer success by owning and optimizing digital engagement programs. You'll lead strategy, build automated journeys, and analyze performance to enhance customer experiences and ensure...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$130K - $150K *

Optimize complex Salesforce implementations by leading cross-functional teams, managing project lifecycles, and ensuring successful client outcomes through effective communication and risk management...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$80K - $90K *

Join a team that's dedicated to strategic program execution and risk mitigation. As a key analyst, you'll prepare and evaluate initiatives, collaborate across functions, and drive project success thro...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Staffing

$69K - $107K *

Champion client success by leveraging technical expertise to enhance platform value, optimize workflows, and drive measurable outcomes. Collaborate with cross-functional teams to deliver innovative so...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Join a team that's transforming multi-cloud infrastructure. As a Staff Software Engineer, you'll design and build a cohesive platform across AWS, GCP, and Azure, leading a multi-component system while...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$223K - $255K *

Shape the future of patient access through science and evidence. In this field-based role, engage with national and regional payers, providing medical leadership and insights to inform access decision...

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead and develop a high-performing Applied AI team, driving the delivery of production AI systems while ensuring security, reliability, and operational excellence in healthcare applications...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$88K - $94K *

Join a team that's dedicated to serving our nation's heroes as a Registered Nurse. Make a meaningful impact while providing compassionate care in a supportive environment. Your skills will help enhanc...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Lead the charge in delivering comprehensive primary care for patients ages 2+, focusing on prevention and wellness. Collaborate with a dedicated team to manage health conditions and empower patients t...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$85K - $95K *

Drive growth by identifying where US salon owners engage, creating impactful campaigns, and optimizing landing pages. Collaborate across teams to enhance Slick's presence in the beauty sector, leverag...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$70K - $120K *

Elevate your career by supporting critical data center projects through startup, commissioning, and training activities. Collaborate with teams to ensure systems meet design intent and client expectat...

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Unlock potential by leading technical solutions for enterprise SaaS implementations. Collaborate closely with clients to translate business needs into actionable technical designs, ensuring successful...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$82K - $100K *

Join a team that's redefining group sales in the flexible accommodations industry. Drive revenue through strategic relationship building and sales execution, while transforming how corporate and group...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Hospitality & Recreation

$125K - $145K *

Unlock potential by leading complex multi-disciplinary projects to achieve client goals, overseeing contracting, risk management, and deliverable production, while supporting program growth and commun...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Technical Services

$150K - $180K *

Champion the future of revenue operations by leading GTM infrastructure, analytics, and team scaling across multiple verticals. Drive strategic initiatives to enhance efficiency and revenue growth in...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$80K - $90K *

Take ownership of day-to-day campaign execution for paid search and affiliate marketing channels while driving performance optimizations and ensuring data integrity across multiple retail brands in a...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$88K - $95K *

Elevate healthcare access by providing clinical support and driving sales growth across government accounts. Collaborate with VA and DoD partners to expand Cochlear's hearing solutions in the Ohio/Ind...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$145K - $175K *

Lead the charge in shaping enterprise architecture by defining standards, guiding technology decisions, and developing roadmaps that align business priorities with scalable, secure solutions across ap...

Yesterday

  •   11 - 15 years exp.  •   Finance & Insurance

$95K - $115K *

Empower your career by leading risk management initiatives, ensuring compliance, and enhancing the Enterprise Risk Management framework. Collaborate with stakeholders to mitigate risks and drive strat...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Lead and inspire a team of 20 associates to enhance client experiences and support branch operations. Drive performance, talent development, and stakeholder partnerships while navigating a regulated e...

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $295K *

Lead the charge in optimizing global delivery operations, ensuring seamless hub economics and resource allocation. Collaborate with finance and commercial teams to drive data-driven decisions and main...

Reposted yesterday

  •   Less than 5 years exp.  •   Media

$115K - $140K *

Join a team that's dedicated to transforming patient engagement through innovative marketing strategies. You'll develop and execute multichannel campaigns, crafting compelling content that drives enro...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.