Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$104K - $166K *
Shape the future of cybersecurity by leading vulnerability management initiatives, enhancing security posture, and driving remediation efforts across diverse environments. Collaborate with teams to en...
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Information Assurance/Security Engineer Manager
$104K - $166K *
Take ownership of cybersecurity initiatives by managing complex projects, ensuring compliance with federal regulations, and leading a team of experts to enhance incident response and information assur...
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DEA IT Modernization – Explore Career Opportunities with Peraton
$146K - $234K *
Lead the charge in shaping federal IT programs by leveraging your DOJ or DEA experience. Collaborate with a team of experts to drive proposal development and manage complex projects in a dynamic envir...
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$92K - $115K *
Drive successful client implementations by managing projects from inception to deployment. Collaborate cross-functionally to ensure timely, on-budget delivery while interfacing with stakeholders and v...
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$142K - $177K *
Lead the charge in establishing strategic partnerships with pharmaceutical manufacturers, driving contract negotiations for rebates and discounts while enhancing client relationships and supporting fo...
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Clinical Account Executive (RPh) - Archimedes
$100K - $120K *
Bring your expertise to a dynamic role as a Clinical Account Executive, where you'll lead specialty medication management, collaborate with healthcare professionals, and drive formulary development to...
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$88K - $115K *
Empower organizational change by analyzing stakeholder needs and implementing effective strategies. Collaborate with leadership and teams to enhance processes, ensuring smooth transitions and measurab...
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$90K - $100K *
Unlock potential by managing and optimizing learning management systems for federal healthcare training. Collaborate with diverse teams to ensure effective course delivery, learner access, and accurat...
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$102K - $111K *
Join a team that's dedicated to enhancing digital learning resources by managing SharePoint training sites, ensuring content accuracy, and supporting effective training experiences for federal healthc...
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$31K - $130K *
Empower clients on their debt relief journey by providing compassionate consultations. Utilize your expertise to navigate sensitive conversations, ensuring clients regain financial confidence while ac...
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$180K - $210K *
Lead a dynamic team to support shipyard operations, ensuring project success through strategic direction, effective communication, and performance management while fostering relationships and driving...
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RFID SME – Label Printing & Automation
$92K - $158K *
Drive innovative RFID solutions by leading design, customer engagement, and technical validation. Collaborate with teams to deliver reliable identification and tracking systems, ensuring alignment wit...
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$122K - $211K *
Champion the development of a secure, user-centric application for managing mission data and digital assets, ensuring seamless integration and collaboration while leading a team of developers in a dyn...
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Hardware Operations Specialist
$92K - $158K *
Empower cross-functional collaboration and operational efficiency in hardware development. Support project execution and coordination, ensuring alignment across teams while managing multiple prioritie...
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$112K - $192K *
Join a dynamic team to develop and refine cost estimates for critical federal programs, ensuring effective budgetary decisions and enhancing national security through advanced technology solutions...
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Senior Atlassian Solution Architect
$140K - $200K *
Empower innovation by leading the design of secure, scalable Atlassian Cloud environments. This senior role involves architecture, migration strategy, and technical leadership to support modernization...
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$80K - $95K *
Champion complex LTC Professional Liability claims, managing them from inception to resolution. Collaborate with experts and leadership to shape strategies, ensuring effective outcomes in a high-stake...
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$104K - $156K *
Lead the design, development, and integration of AI applications that enhance business operations. Collaborate with cross-functional teams to deliver technical solutions while maintaining security, re...
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$89K - $109K *
Drive project accounting excellence by leading a team, ensuring accurate billing, and collaborating with project managers. Oversee financial reporting and client relations while mentoring junior staff...
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Analyst - Operations Financials I
$60K - $115K *
Transform your career by managing financial processes and compliance, analyzing project health, and training teams. Collaborate with stakeholders to ensure effective financial deliverables and reporti...
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$130K - $185K *
Unlock insights at scale by transforming complex healthcare data into actionable analytics solutions. Collaborate with cross-functional teams to design and optimize data models, ensuring high-quality...
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$165K - $185K *
Lead the charge in healthcare data integration by analyzing source systems, designing database objects, and ensuring compliance with governance policies to support the Corporate Data Warehouse...
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$94K - $120K *
Lead the charge in delivering impactful IT projects by managing all phases from initiation to closeout. Collaborate with diverse teams to ensure timely and successful project execution while aligning...
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$385K - $416K *
Champion clinical expertise in birth defects research, overseeing case classification and quality control. Collaborate with multidisciplinary teams to ensure accurate data management and support publi...
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Enterprise Applications Architect
$116K - $155K *
Transform enterprise applications through strategic architecture, integration, and governance. Collaborate with stakeholders to enhance business processes and ensure reliable operation of platforms wh...
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What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.