Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$500K+*

Transform enterprise sales by driving new logo acquisition for our AI platform. Own the full sales cycle, from prospecting to closing, while building relationships with key executives in target indust...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$114K - $128K *

Lead the charge in AI-augmented product delivery, ensuring quality and flow across initiatives. Collaborate with cross-functional teams to manage project milestones and facilitate decision-making in a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Drive the future of finance data analysis by ensuring accuracy and usability of financial data. Collaborate with finance and data teams to enhance reporting processes and validate data integrity for i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$148K - $222K *

Unlock opportunities as you collaborate with healthcare providers to enhance patient access and reimbursement strategies. Drive education on payer policies and support services while building strong r...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$115K - $125K *

Lead the charge in product marketing by owning go-to-market launches and creating engaging content. Collaborate with teams to translate technical improvements into customer benefits, ensuring successf...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $95K *

Unlock potential by designing innovative digital experiences that inspire and engage. Collaborate with teams to create user-centered solutions, leveraging research and creativity to tackle complex cha...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$115K - $165K *

Lead the commissioning of critical facilities by managing project life cycles, collaborating with diverse teams, and ensuring compliance with specifications. Drive project success through effective co...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$180K - $261K *

Shape the future of product marketing by driving growth through strategic enablement, cross-functional collaboration, and compelling storytelling that connects technical solutions to customer needs in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Innovate secure agentic workflows for mission-critical GEOINT systems. Collaborate with diverse teams to design, integrate, and deploy applications that enhance operational efficiency and automate pro...

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $150K *

Join a dynamic team to lead risk management for large-scale construction projects. Drive risk identification, reporting, and mitigation strategies while collaborating with diverse stakeholders to ensu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$91K - $146K *

Join a team that's dedicated to optimizing HR processes through effective management of the Workday HRIS. Collaborate with HR and IT to enhance system functionality, ensure data integrity, and support...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$125K - $160K *

Unlock potential by leveraging your technical expertise and consultative skills to drive sales growth and enhance customer relationships through tailored technology solutions and strategic conversatio...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $190K *

Join a dynamic team as a Criticality Analysis & Nuclear Safety Engineer, responsible for ensuring nuclear safety in advanced fuel fabrication. Collaborate across disciplines to develop safety analyses...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$95K - $115K *

Lead the charge in ensuring the successful testing and implementation of SNAP EBT services. Collaborate with state personnel and processors to develop comprehensive test plans, validate requirements...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$184K - $253K *

Drive strategic partnerships and technology transactions as a Senior Counsel, overseeing complex agreements and M&A support. Collaborate cross-functionally to build processes and provide business-focu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$190K - $220K *

Lead the charge in shaping the go-to-market strategy for innovative data security services, driving customer adoption and engagement through compelling narratives and strategic partnerships across tea...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Unlock potential by driving partnerships within health systems, building strategic relationships, and creating impactful ecosystems that accelerate product adoption and streamline sales cycles, while...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$184K - $356K *

Engage in safeguarding intellectual property within engineering teams by establishing secure workflows, creating training materials, and managing security policies. Collaborate effectively across team...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$90K - $120K *

Join a team that's dedicated to empowering clients through expert family law representation. This role offers meaningful courtroom experience, professional development, and a supportive environment to...

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$113K - $178K *

Empower dental sales growth by collaborating with leadership to develop effective strategies. Build strong relationships, enhance customer offerings, and drive success across key accounts while leadin...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $155K *

Elevate data product experiences by defining metrics that drive value for Mural. Collaborate across teams to shape insights, enhance reporting, and ensure data integrity, empowering organizations to m...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Lead the charge in driving sales success by implementing strategic plans and engaging healthcare professionals. Utilize your expertise to optimize customer interactions and exceed performance objectiv...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $125K *

Drive your career with a dynamic sales role, owning the full cycle from prospecting to closing. Collaborate with leadership, build strategic account plans, and leverage your expertise to achieve consi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$175K - $190K *

Lead and mentor a team of Program Managers to drive strategic data center builds, ensuring seamless execution and stakeholder alignment while navigating complex infrastructure challenges in a high-gro...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$165K - $175K *

Unlock potential by leading enterprise data engineering initiatives, driving platform modernization, and enhancing operational excellence. Collaborate with cross-functional teams to deliver scalable...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.