Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$85K - $100K *

Champion compliance excellence by reviewing retail communications to ensure adherence to regulations and firm policies. Collaborate with teams to maintain high standards and support organizational goa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $300K *

Accelerate sales growth in the Pacific Northwest by leading a dynamic team in Washington, Oregon, and Idaho. Drive accountability, enhance pipeline management, and foster a high-performance culture th...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$235K - $250K *

Transform financial strategy and compliance in a dynamic fintech environment. Lead financial operations, banking relationships, and compliance initiatives to drive growth and manage risk effectively w...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $140K *

Elevate healthcare consulting by leading complex actuarial projects, developing financial models, and advising clients on policy impacts. Collaborate with teams to analyze data, mentor analysts, and e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Champion global clinical trials by leading project teams to deliver excellence on time and within budget, ensuring high-quality outcomes that exceed client expectations in the biotech and pharma secto...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a dynamic team as you drive account retention and growth, collaborating with creative and operations departments to deliver exceptional client service and innovative solutions while managing proj...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$95K - $115K *

Lead and manage complex construction projects, ensuring safety, quality, and client satisfaction while coordinating with diverse teams and stakeholders to deliver on time and within budget...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $185K *

Unlock potential by designing and maintaining scalable backend systems for complex data integrations. Collaborate with partners to enhance operational efficiency and reliability, ensuring seamless dat...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$105K - $125K *

Take ownership of safety initiatives across multiple construction sites, ensuring compliance and fostering a culture of safety. Collaborate with teams to educate and implement best practices while con...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Drive medication therapy management services by conducting comprehensive reviews and consultations. Collaborate with the MTM product team to ensure accurate data entry and enhance patient care through...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Join a team that's redefining enterprise sales by engaging C-suite stakeholders in Tier 1 banks and credit unions. Drive complex sales cycles, build strategic relationships, and deliver tailored solut...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Manage the implementation process for clients in Revenue Cycle Management, ensuring efficient setup and optimization of billing workflows. Serve as the primary expert, guiding healthcare organizations...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Engineer innovative civil designs for utility-scale solar and battery projects. Collaborate with multidisciplinary teams to create site layouts, grading, and drainage plans, ensuring compliance and ef...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$110K - $130K *

Lead a dynamic construction team, driving profitable growth and project success while ensuring safety, quality, and client satisfaction. Foster high-performance culture and manage resources effectivel...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $120K *

Engage with key stakeholders to support technology launches, educating surgical teams and ensuring effective integration of cutting-edge systems for improved patient outcomes and sustainable practices...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$210K *

Empower patients through innovative telehealth solutions, providing comprehensive virtual care across various medical disciplines while maintaining work-life balance and clinical excellence in a fully...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$210K *

Elevate patient care by delivering high-quality telehealth services across Missouri. Collaborate with a dynamic team to manage diverse clinical cases, ensuring compassionate and effective virtual cons...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $176K *

Transform patient care by leading a pharmacy team to deliver exceptional service, ensuring compliance, and fostering a culture of excellence while driving performance improvements and supporting team...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$126K - $234K *

Unlock potential by designing and delivering innovative training solutions for customer-facing teams, enhancing product knowledge and engagement skills across diverse therapeutic areas and roles...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$115K - $140K *

Join us to drive revenue growth by engaging senior finance leaders, executing full-cycle sales, and delivering tailored software solutions that address financial challenges and enhance operational eff...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $140K *

Unlock your potential as a Forward Deployed Engineer, bridging AI solutions with enterprise needs. Collaborate closely with clients to architect and implement robust systems, ensuring real-world appli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $150K *

Transform the mobile landscape by architecting a scalable React Native application. Lead engineering standards, mentor developers, and integrate enterprise systems to enhance user experience across iO...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Transportation

$110K - $130K *

Grow your career with a dynamic design role focused on transforming complex supply chain systems into intuitive user experiences. Collaborate with teams to enhance operational efficiency and drive imp...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$89K - $111K *

Engage in strategic sales management and relationship growth, overseeing account development, promotional planning, and data analysis to maximize profitability and enhance partnerships with key retail...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Join the charge in shaping CoreView's Federal market presence by leading strategic field marketing initiatives, enhancing brand awareness, and driving lead generation campaigns to establish a robust p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.