Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $116,335
Director Software Engineering - Central Security
$180K - $220K *
Drive the development of innovative security systems using AI/ML, managing risk across identity and access management. Collaborate with cross-functional teams to enhance security while maintaining ope...
1 week ago
General Liability Claim Representative
$90K - $110K *
Champion the management of complex liability claims, ensuring thorough investigations, negotiations, and settlements. Collaborate with internal and external stakeholders to maintain high standards of...
1 week ago
Principal Solutions Consultant
$150K - $180K *
Transform enterprise AI initiatives by leading technical pursuits, architecting scalable solutions, and driving impactful client engagements. Collaborate across teams to ensure successful delivery and...
1 week ago
$145K - $185K *
Transform the Cyber operations landscape by leading business development, shaping solutions, and executing contracts. Build trusted relationships, manage a diverse portfolio, and drive customer satisf...
Reposted 1 week ago
Pharmacy Operations Optimization Manager - KitCheck
$110K - $125K *
Shape the future of pharmacy operations by optimizing customer engagement and operational performance across a national portfolio. Drive proactive interventions and enhance workflow efficiency to ensu...
1 week ago
Privacy Program Optimization Manager - PrivacyPro
$110K - $125K *
Elevate customer engagement by optimizing privacy program performance across a diverse portfolio. Ensure proactive intervention and support for healthcare privacy teams, driving compliance and enhanci...
1 week ago
Channel Account Manager, Partner Sales - VAR Channel
$85K - $114K *
Transform the Value-Added Reseller ecosystem by leveraging channel expertise to drive growth, engaging partners, and developing robust strategies for customer acquisition and revenue expansion within...
Reposted 1 week ago
Sales Manager - Edge Platforms
$500K+*
Accelerate progress at driving new enterprise sales for AI platforms, owning the full sales cycle from prospecting to closing. Engage with CXOs across key industries to deliver measurable business out...
1 week ago
Senior Customer Marketing Manager
$145K - $185K *
Engage the customer lifecycle by developing scalable marketing programs that enhance onboarding, retention, and expansion. Collaborate cross-functionally to transform insights into impactful strategie...
1 week ago
Hematology Therapeutic Specialist (South Texas)
$110K - $130K *
Champion the growth of hematology products by educating healthcare providers, driving demand, and fostering relationships within cancer centers. Leverage cross-functional teams to ensure a positive ex...
1 week ago
$115K - $130K *
Analyze market trends and performance metrics to drive actionable insights across marketing, sales, and revenue operations. Collaborate with cross-functional teams to optimize strategies and enhance g...
1 week ago
Actuarial Director - Remote (Seattle, WA)
$220K - $240K *
Lead the development of client data strategies and actuarial studies, ensuring accurate financial projections and effective communication with clients. Collaborate with teams to optimize health benefi...
Reposted 1 week ago
$150K - $163K *
Join a dynamic Solutions Architecture team to tackle complex technology challenges, drive customer success, and enhance product offerings across diverse industries. Your expertise will shape outcomes...
1 week ago
$95K - $115K *
Lead the development and implementation of technical solutions for clients, ensuring project success through collaboration and effective communication. Drive innovation while maintaining high standard...
1 week ago
Lake City ERP CHP Project Manager
$110K - $130K *
Join a team that's leading complex federal construction projects. Oversee project execution, manage subcontractors, and ensure compliance with safety and quality standards while driving successful pro...
1 week ago
Project Controls Manager and CPM Scheduler - Lake City Microgrid and CHP
$100K - $120K *
Transform project execution by developing and maintaining comprehensive CPM schedules, integrating multiple stakeholders, and ensuring timely updates to drive successful outcomes in large-scale indust...
1 week ago
Director of Property Accounting
$140K - $165K *
Shape the future of property accounting by leading a dynamic team, ensuring timely financial reporting, and driving innovative processes that enhance client trust and operational efficiency across mul...
1 week ago
Customer Marketing Manager, Retention & Advocacy
$95K - $115K *
Empower customer retention and advocacy by leading US-focused programs. Collaborate cross-functionally to enhance customer journeys, ensuring clear communication and value delivery while optimizing en...
1 week ago
Sr. Director, Office of Global Education and Academic Innovation
$95K - $110K *
Lead the charge in advancing global education and academic innovation through strategic operational leadership, enhancing instructional quality, and fostering faculty development across diverse educat...
1 week ago
Senior Vice President, Business Optimization
$140K - $200K *
Champion transformative strategies that enhance operational efficiency and drive sustainable change. Lead a dynamic team to connect priorities with execution, fostering a culture of continuous improve...
1 week ago
Senior Vice President, Business Optimization
$140K - $200K *
Elevate your career by leading transformative initiatives that connect strategy with execution. Drive continuous improvement, foster collaboration, and empower teams to navigate change effectively acr...
1 week ago
Customer Journey Operations Manager
$120K - $150K *
Accelerate customer journey operations by driving scalable processes and systems. Collaborate cross-functionally to enhance customer success, technical support, and partner engagement, ensuring effici...
1 week ago
$80K - $95K *
Join a dynamic team to support real estate litigation, managing cases and collaborating with seasoned attorneys. This role offers growth opportunities in a fast-paced environment, focusing on property...
1 week ago
RN - Registered Nurse ( Night Shift )
$83K - $93K *
Unlock potential by providing compassionate care in a residential detox setting. Collaborate with a dedicated team to support patients through their recovery journey, ensuring safety and adherence to...
1 week ago
Senior Medical Science Liaison, South (Multiple Territories)
$190K - $220K *
Engage with key stakeholders as a Senior Medical Science Liaison, driving prelaunch and launch strategies. Build trusted relationships, deliver scientific insights, and influence adoption in a dynamic...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.