Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$180K - $220K *

Drive the development of innovative security systems using AI/ML, managing risk across identity and access management. Collaborate with cross-functional teams to enhance security while maintaining ope...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $110K *

Champion the management of complex liability claims, ensuring thorough investigations, negotiations, and settlements. Collaborate with internal and external stakeholders to maintain high standards of...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Transform enterprise AI initiatives by leading technical pursuits, architecting scalable solutions, and driving impactful client engagements. Collaborate across teams to ensure successful delivery and...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$145K - $185K *

Transform the Cyber operations landscape by leading business development, shaping solutions, and executing contracts. Build trusted relationships, manage a diverse portfolio, and drive customer satisf...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $125K *

Shape the future of pharmacy operations by optimizing customer engagement and operational performance across a national portfolio. Drive proactive interventions and enhance workflow efficiency to ensu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $125K *

Elevate customer engagement by optimizing privacy program performance across a diverse portfolio. Ensure proactive intervention and support for healthcare privacy teams, driving compliance and enhanci...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $114K *

Transform the Value-Added Reseller ecosystem by leveraging channel expertise to drive growth, engaging partners, and developing robust strategies for customer acquisition and revenue expansion within...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$500K+*

Accelerate progress at driving new enterprise sales for AI platforms, owning the full sales cycle from prospecting to closing. Engage with CXOs across key industries to deliver measurable business out...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$145K - $185K *

Engage the customer lifecycle by developing scalable marketing programs that enhance onboarding, retention, and expansion. Collaborate cross-functionally to transform insights into impactful strategie...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Champion the growth of hematology products by educating healthcare providers, driving demand, and fostering relationships within cancer centers. Leverage cross-functional teams to ensure a positive ex...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$115K - $130K *

Analyze market trends and performance metrics to drive actionable insights across marketing, sales, and revenue operations. Collaborate with cross-functional teams to optimize strategies and enhance g...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$220K - $240K *

Lead the development of client data strategies and actuarial studies, ensuring accurate financial projections and effective communication with clients. Collaborate with teams to optimize health benefi...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $163K *

Join a dynamic Solutions Architecture team to tackle complex technology challenges, drive customer success, and enhance product offerings across diverse industries. Your expertise will shape outcomes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Lead the development and implementation of technical solutions for clients, ensuring project success through collaboration and effective communication. Drive innovation while maintaining high standard...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's leading complex federal construction projects. Oversee project execution, manage subcontractors, and ensure compliance with safety and quality standards while driving successful pro...

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$100K - $120K *

Transform project execution by developing and maintaining comprehensive CPM schedules, integrating multiple stakeholders, and ensuring timely updates to drive successful outcomes in large-scale indust...

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$140K - $165K *

Shape the future of property accounting by leading a dynamic team, ensuring timely financial reporting, and driving innovative processes that enhance client trust and operational efficiency across mul...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Empower customer retention and advocacy by leading US-focused programs. Collaborate cross-functionally to enhance customer journeys, ensuring clear communication and value delivery while optimizing en...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $110K *

Lead the charge in advancing global education and academic innovation through strategic operational leadership, enhancing instructional quality, and fostering faculty development across diverse educat...

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$140K - $200K *

Champion transformative strategies that enhance operational efficiency and drive sustainable change. Lead a dynamic team to connect priorities with execution, fostering a culture of continuous improve...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $200K *

Elevate your career by leading transformative initiatives that connect strategy with execution. Drive continuous improvement, foster collaboration, and empower teams to navigate change effectively acr...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $150K *

Accelerate customer journey operations by driving scalable processes and systems. Collaborate cross-functionally to enhance customer success, technical support, and partner engagement, ensuring effici...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Join a dynamic team to support real estate litigation, managing cases and collaborating with seasoned attorneys. This role offers growth opportunities in a fast-paced environment, focusing on property...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$83K - $93K *

Unlock potential by providing compassionate care in a residential detox setting. Collaborate with a dedicated team to support patients through their recovery journey, ensuring safety and adherence to...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$190K - $220K *

Engage with key stakeholders as a Senior Medical Science Liaison, driving prelaunch and launch strategies. Build trusted relationships, deliver scientific insights, and influence adoption in a dynamic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.