Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $116,335
Senior Medical Science Liaison, West (Multiple Territories)
$190K - $220K *
Champion scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment. Operate i...
1 week ago
Senior Medical Science Liaison, Southeast (Multiple Territories)
$190K - $220K *
Engage with key stakeholders to drive prelaunch and launch strategies, translating clinical data into actionable insights. Build trusted relationships and ensure readiness for successful product adopt...
1 week ago
Sales & Product Enablement Manager (US, Remote)
$100K - $120K *
Join a dynamic team to develop and implement sales enablement strategies that empower customer-facing teams with essential product knowledge and training, driving organizational success and enhancing...
1 week ago
Senior Manager, Network Operations
$115K - $125K *
Champion operational excellence by managing cross-regional teams, ensuring consistent performance standards, and facilitating effective agent execution. Drive strategic initiatives and resolve conflic...
1 week ago
$160K - $200K *
Unlock potential by leading strategic sales initiatives that drive growth and forge strong relationships with key retail and eCommerce clients in a fast-paced environment requiring frequent travel. In...
Reposted 1 week ago
Salesforce Solution Architect, Experience Cloud
$94K - $266K *
Manage client relationships by delivering strategic Salesforce solutions, leveraging technology, optimizing processes, and mentoring junior team members to drive both immediate impact and long-term su...
Reposted 1 week ago
Strategic Customer Success Manager
$145K - $200K *
Accelerate customer success by guiding clients through onboarding, adoption, and risk mitigation. Leverage your expertise to build relationships, drive renewals, and identify expansion opportunities...
Reposted 1 week ago
Associate Director, Corporate Accounts - Food and Beverage (Beverage and Brewing)
$135K - $198K *
Unlock strategic growth by cultivating partnerships in the Beverage & Brewing sector. Collaborate with senior stakeholders to enhance customer success through innovative solutions, driving long-term v...
1 week ago
$99K *
Deliver high-quality MRI examinations for research, ensuring compliance with best practices and HIPAA regulations. Collaborate with staff to enhance imaging technologies and maintain efficient project...
1 week ago
Clinical Applications Specialist - Dosimetrist (Travelling position)
$123K - $169K *
Unlock your potential by providing expert clinical training and support to customers, ensuring they effectively operate advanced dosimetry equipment. Collaborate with cross-functional teams to enhance...
1 week ago
Sr Strategic Alliances Manager
$110K - $130K *
Champion strategic alliances to drive growth, enhance partnerships, and align cross-functional teams. Lead initiatives that translate company goals into actionable plans, ensuring measurable results a...
1 week ago
Sales Enablement Lead (Medical Device)-Remote within the US
$110K - $151K *
Drive sales enablement excellence by equipping teams with strategic tools, training, and resources to enhance customer engagement and revenue outcomes in the Radiation Oncology Solutions sector...
1 week ago
Principal / Senior Staff Backend Engineer
$200K - $250K *
Innovate and shape the technical strategy for a cutting-edge exchange platform. Lead high-impact initiatives, mentor engineers, and drive architectural decisions in a regulated environment to enhance...
1 week ago
$80K - $100K *
Drive the success of multiple claims teams by supervising operations, providing technical guidance, and ensuring quality standards. Collaborate with management to enhance processes and maintain strong...
1 week ago
Senior Director, Engineering, Precision Defense
$270K - $365K *
Lead a dynamic engineering organization to transform offensive capabilities into proactive defense. Shape strategy, scale teams, and deliver innovative solutions across multiple pillars, ensuring robu...
1 week ago
Contract and Billing Specialist
$84K - $128K *
Join a team that's dedicated to resolving complex billing and contract cases for Mid-Market and Commercial accounts. You'll collaborate cross-functionally to enhance customer satisfaction and streamli...
1 week ago
Sr. Manager, Enterprise Customer Success - Select
$125K - $169K *
Transform customer outcomes by leading a high-performing team dedicated to leveraging Samsara's solutions. Drive strategic growth while ensuring enterprise clients realize sustained value from their i...
Reposted 1 week ago
$110K - $130K *
Oversee the implementation and onboarding process for multiple client partners, ensuring a seamless experience from contract execution to go-live while collaborating cross-functionally to drive succes...
1 week ago
$96K - $159K *
Optimize sales strategies and manage agency relationships to drive profitable growth. Leverage advanced analytics and digital tools to enhance performance and foster collaboration, ensuring alignment...
1 week ago
$125K - $150K *
Take ownership of a fully distributed engineering team, driving delivery, quality, and growth while fostering a culture of communication and continuous improvement. Collaborate with cross-functional p...
1 week ago
Senior Staff Accountant, Structured Finance
$95K - $115K *
Shape the future of financial reporting by managing complex accounting activities, ensuring compliance, and collaborating with cross-functional teams to enhance operational efficiency and internal con...
1 week ago
$125K - $150K *
Lead a distributed engineering team to deliver high-quality software solutions. Foster a culture of ownership and continuous improvement while collaborating with cross-functional partners to drive bus...
1 week ago
$70K - $105K *
Lead the charge in enhancing brain health initiatives by providing clinical guidance and support to healthcare professionals, ensuring effective care coordination and education across partner sites in...
1 week ago
$96K - $145K *
Accelerate your career by supporting critical mainframe applications, collaborating with cross-functional teams to enhance system performance and resolve complex issues, while driving continuous impro...
1 week ago
Associate Operations Counsel (Remote Opportunity)
$112K - $149K *
Join a team that's dedicated to providing legal support in mortgage servicing. You'll ensure compliance with regulations, draft essential documents, and collaborate with operational teams to minimize...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.