Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$150K - $180K *

Lead a talented team in crafting a high-quality, scalable object storage product that enhances the developer experience, balancing technical execution with product thinking to drive meaningful improve...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$98K - $115K *

Unlock potential by driving innovative software solutions through analysis, design, and development. Collaborate across teams to enhance customer experiences while adhering to best practices in coding...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$116K - $150K *

Drive transformative consulting solutions by leveraging SAP Finance expertise, guiding teams through project lifecycles, and engaging with C-suite stakeholders to meet evolving client needs in the Fin...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$140K - $170K *

Shape the future of insurance technology by leveraging your expertise to guide Life, Annuity & Health insurers in modernizing operations and enhancing customer experiences through innovative solutions...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$126K - $149K *

Unlock potential by guiding the implementation of accounting standards, driving compliance while supporting various business units to enhance decision-making and optimize financial practices in a fast...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in transforming client operations by identifying and accelerating AI-driven opportunities. Collaborate with stakeholders to frame business challenges, prototype solutions, and drive me...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $225K *

Pioneer innovative design solutions as a Staff Product Designer, driving AI-powered workflows and enhancing user experiences in a complex legal tech environment. Collaborate closely with engineering t...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Legal & Accounting

$80K - $110K *

Contribute to the success of aviation projects by leading design and analysis efforts, managing tasks, and ensuring compliance with regulations while mentoring junior engineers and collaborating with...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$126K - $154K *

Transform healthcare payment solutions by driving business growth and optimizing client relationships. Leverage your expertise to develop tailored proposals and secure long-term partnerships with larg...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$126K - $154K *

Empower healthcare organizations by optimizing payment solutions and driving growth. This remote role involves building executive relationships and addressing complex revenue cycle challenges within m...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$197K - $240K *

Elevate business banking operations by leading a dynamic team to drive growth, enhance client relationships, and ensure compliance. Foster a customer-centric culture while achieving financial targets...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Unlock potential by managing system design, build, and support for applications, ensuring optimal functionality and user satisfaction while collaborating across teams to enhance workflows and resolve...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $155K *

Empower your career by ensuring the quality and performance of Salesforce solutions in Government Cloud environments. Collaborate with cross-functional teams to validate requirements and enhance testi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Elevate your career by leading a dynamic team in data engineering and AI-ready data enablement. Drive innovation, mentor talent, and collaborate with IT and business teams to create trusted data produ...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$106K - $284K *

Elevate your career by leading the design and development of innovative healthcare platforms. Collaborate with cross-functional teams to deliver scalable, secure applications that enhance user experie...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$237K - $275K *

Join a team that's redefining client partnerships by owning strategic accounts, driving revenue growth, and ensuring client satisfaction through integrated solutions and executive relationships across...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Media

$150K - $180K *

Champion global physical security and resiliency initiatives by providing strategic leadership to enhance safety for employees and assets while driving compliance across all company operations and thi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Partner with us to drive innovative solutions as a Principal Architect, engaging in multi-faceted pre-sales and delivery efforts. Collaborate with teams and clients to enhance customer experiences and...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$105K - $147K *

Join us to accelerate progress at the forefront of software development for defense systems, engaging in the design, testing, and maintenance of robust solutions that support mission-critical operatio...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$130K - $195K *

Join a dynamic AI Automation team to design and deliver production-grade AI agents and workflows, enhancing operational efficiency across the organization while solving complex business challenges wit...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$96K - $130K *

Join a dynamic team to shape innovative fundraising tools that empower progressive campaigns and nonprofits. Leverage modern technologies to enhance election readiness and compliance, while mentoring...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$144K - $200K *

Transform public safety sales by leading a regional team, enhancing performance, and driving success through effective coaching and recruitment. Collaborate across departments to build a predictable p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$90K - $110K *

Drive quality assurance for ICT cabling infrastructure across 700+ Army Reserve sites. Collaborate with engineering teams and contractors to ensure compliance with technical standards and deliver exce...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Engage with key stakeholders to deliver innovative solutions, providing pre-sales technical support and strategic technology plans that drive customer success and enhance business outcomes across dive...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Champion the modernization of SLED organizations by guiding them through technical evaluations and deployments of GitLab's DevSecOps platform, ensuring compliance and enhancing service delivery across...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.