Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$130K - $158K *

Engage with a dynamic Federal sales team to drive revenue growth, coach sales reps, and enhance client relationships. Lead strategic initiatives in the Federal vertical, leveraging your expertise to c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$198K - $233K *

Empower a team of engineers by architecting a robust AI-driven development pipeline, enhancing workflows across mobile and backend systems, and ensuring reliable, efficient software delivery for milli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$107K - $180K *

Lead the charge in empowering sales teams through innovative enablement programs, training, and resources. Collaborate across departments to optimize processes and enhance seller effectiveness, drivin...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$140K - $220K *

Elevate the sales effectiveness of a dynamic team by creating impactful training and content. Collaborate closely with reps to enhance deal preparation and drive success across a diverse portfolio in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in project management for global Metabolic/GLP-1 studies, ensuring outstanding delivery, budget management, and client satisfaction while guiding and mentoring project teams toward ope...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$142K - $193K *

Drive enterprise growth by managing complex accounts and executing strategic sales initiatives. Collaborate cross-functionally to deliver customer-centric solutions and achieve measurable business out...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$135K - $150K *

Join a dynamic team to drive advanced threat hunting strategies, mentor global security teams, and develop innovative cybersecurity scenarios. Leverage your expertise in incident response and AI to en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $110K *

Drive impactful insights by analyzing real-world data in the life sciences sector. Collaborate with cross-functional teams to enhance patient care and support evidence-based decision-making through in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Lead the charge in managing Banking Center operations, ensuring exceptional customer service and sales performance while overseeing staff and compliance with banking regulations. Drive business develo...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Transform customer experiences by leading retail banking operations and teams. Drive sales initiatives, ensure compliance, and foster a positive environment while managing branch performance and staff...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Lead the strategic management of banking center operations, ensuring exceptional customer service and sales performance while overseeing staff and compliance with banking regulations. Drive business d...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Transform retail banking by leading Banking Center Managers and operations. Drive sales, enhance customer experiences, and ensure compliance while fostering a collaborative team environment to achieve...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Lead a talented team in crafting a high-quality, scalable object storage product that enhances the developer experience, balancing technical execution with product thinking to drive meaningful improve...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$98K - $115K *

Unlock potential by driving innovative software solutions through analysis, design, and development. Collaborate across teams to enhance customer experiences while adhering to best practices in coding...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$116K - $150K *

Drive transformative consulting solutions by leveraging SAP Finance expertise, guiding teams through project lifecycles, and engaging with C-suite stakeholders to meet evolving client needs in the Fin...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$140K - $170K *

Shape the future of insurance technology by leveraging your expertise to guide Life, Annuity & Health insurers in modernizing operations and enhancing customer experiences through innovative solutions...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$126K - $149K *

Unlock potential by guiding the implementation of accounting standards, driving compliance while supporting various business units to enhance decision-making and optimize financial practices in a fast...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in transforming client operations by identifying and accelerating AI-driven opportunities. Collaborate with stakeholders to frame business challenges, prototype solutions, and drive me...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $225K *

Pioneer innovative design solutions as a Staff Product Designer, driving AI-powered workflows and enhancing user experiences in a complex legal tech environment. Collaborate closely with engineering t...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Legal & Accounting

$80K - $110K *

Contribute to the success of aviation projects by leading design and analysis efforts, managing tasks, and ensuring compliance with regulations while mentoring junior engineers and collaborating with...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$126K - $154K *

Transform healthcare payment solutions by driving business growth and optimizing client relationships. Leverage your expertise to develop tailored proposals and secure long-term partnerships with larg...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$126K - $154K *

Empower healthcare organizations by optimizing payment solutions and driving growth. This remote role involves building executive relationships and addressing complex revenue cycle challenges within m...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$197K - $240K *

Elevate business banking operations by leading a dynamic team to drive growth, enhance client relationships, and ensure compliance. Foster a customer-centric culture while achieving financial targets...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Unlock potential by managing system design, build, and support for applications, ensuring optimal functionality and user satisfaction while collaborating across teams to enhance workflows and resolve...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $155K *

Empower your career by ensuring the quality and performance of Salesforce solutions in Government Cloud environments. Collaborate with cross-functional teams to validate requirements and enhance testi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.