Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$100K - $150K *

Lead the charge in environmental policy analysis and compliance, ensuring adherence to NEPA and other regulations. Collaborate with agencies, conduct research, and draft reports to support sustainable...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$83K - $110K *

Lead operational excellence by managing complex training programs and enhancing processes for a statewide initiative, ensuring effective communication and client engagement while fostering a high-perf...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$87K - $110K *

Engage with customers to ensure their success through onboarding, training, and support. Build strong relationships, manage inquiries, and collaborate with teams to enhance customer satisfaction and d...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K *

Unlock growth by leading sales initiatives with financial intermediaries, developing strategies to enhance client relationships, and driving MFS Investment products across diverse channels to achieve...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$200K - $350K *

Transform complex AI research into scalable, reliable systems. Collaborate across teams to architect and enhance backend services, ensuring robust infrastructure for model training and data collection...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $101K *

Manage web production and optimize digital experiences by collaborating with stakeholders, executing content strategies, and analyzing performance metrics to enhance engagement across online platforms...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$272K - $374K *

Join a team that's driving innovation in machine identity security, focusing on Secrets Management and Agentic AI Security. Collaborate with sales teams to enhance customer adoption and secure non-hum...

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's dedicated to enhancing patient care through operational and clinical pharmacy services in critical care settings. Utilize your expertise to support adult patients in various intensi...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$75K - $90K *

Join a team that's focused on driving revenue growth through strategic partnerships. You'll build lasting relationships, identify upsell opportunities, and collaborate with internal teams to deliver t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Launch impactful B2B events by developing strategies, managing budgets, and executing flawless experiences. Collaborate with marketing leaders to enhance brand presence and foster relationships throug...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$121K - $142K *

Elevate automation in software engineering by building AI-driven tools and systems. Collaborate with a focused team to enhance reliability and speed in package and image management, shaping the future...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$74K - $166K *

Drive workforce development by architecting training programs that enhance skills and align with business goals, ensuring effective learning while balancing production needs in a dynamic manufacturing...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$160K - $225K *

Shape the future of consumer experiences by leading product strategy, driving measurable outcomes, and collaborating with cross-functional teams to enhance member satisfaction throughout their shoppin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$82K - $106K *

Advance your career by leading B2B paid search strategies and driving client growth through data-driven insights, performance management, and effective cross-team collaboration in a dynamic marketing...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$71K - $107K *

Drive logistics excellence by leading and developing a high-performing team, ensuring safety and efficiency in operations while fostering a culture of continuous improvement and collaboration across d...

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$92K - $116K *

Lead the charge in developing and executing customer lifecycle marketing campaigns that enhance engagement, retention, and advocacy, while collaborating with cross-functional teams to drive measurable...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$100K - $120K *

Transform oral healthcare by providing comprehensive dental services, diagnosing conditions, and developing treatment plans. Collaborate with a dedicated team to enhance patient outcomes and serve und...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Lead the charge in managing and optimizing WEKA deployments for AI hyperscaler customers, ensuring seamless data layer operations and infrastructure tuning to meet diverse workloads while maintaining...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$111K - $167K *

Join a dynamic team as a strategic analytics partner, driving insights and performance improvements across revenue cycle operations. Collaborate with leaders to define KPIs, analyze data, and create i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$150K - $250K *

Unlock potential by leading innovative clinical documentation initiatives that enhance quality, compliance, and revenue cycle outcomes. Collaborate with cross-functional teams to redefine workflows an...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$92K - $126K *

Drive innovative solutions by blending product analytics and low-code development, collaborating cross-functionally to enhance AI Agent capabilities and optimize Revenue Cycle operations within the he...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$150K - $240K *

Optimize coding workflows by leveraging your 10+ years of leadership in coding, compliance, and revenue cycle management. Collaborate with AI and engineering teams to drive innovation and enhance oper...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$109K - $179K *

Join a team that's shaping regulatory strategies for advertising and promotion. Leverage your expertise to ensure compliance while collaborating with cross-functional teams to drive impactful product...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $130K *

Lead the charge in advancing automation and controls technologies across global operations, ensuring compliance and operational readiness while collaborating with international teams to implement inno...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$120K - $160K *

Analyze complex operational data to drive insights and improve customer outcomes. Collaborate with cross-functional teams, lead impactful analyses, and create self-service analytics tools to enhance d...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.