Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$110K - $130K *

Champion strategic marketing initiatives to drive growth in North America. Collaborate with cross-functional teams to develop market strategies, analyze trends, and enhance customer engagement, ensuri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$120K - $145K *

Drive impactful change by optimizing product operations through collaborative process design, ensuring alignment and efficiency while fostering innovation and simplification across complex product tea...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$110K - $130K *

Unlock potential by leading a global team in Trust Services, enhancing client relationships, and driving operational excellence. Shape the future of AI-powered security solutions while ensuring top-ti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$153K - $268K *

Join a team that's advancing regulatory strategies for drug substance manufacturing. Lead the charge in selecting and justifying Regulatory Starting Materials, ensuring compliance with global guidelin...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $170K *

Shape the future of enterprise infrastructure by leading design, implementation, and optimization of systems. Drive automation, enhance security, and mentor junior staff while collaborating on strateg...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Join a dynamic team to drive operational excellence through data-driven strategies. Lead workforce planning, enhance performance metrics, and collaborate across functions to optimize patient services...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$200K - $225K *

Unlock growth by leading strategic partnerships in the CDMO sector. Drive sales, nurture client relationships, and collaborate across teams to enhance market presence and customer satisfaction. Your e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$170K - $230K *

Join us to drive the adoption of innovative satellite services for enterprise customers. You'll manage complex deals, execute strategic initiatives, and collaborate cross-functionally to enhance custo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$88K - $105K *

Oversee daily accounting operations, ensuring accurate financial reporting and compliance. Lead a team while managing financial closings, audits, and internal controls to support strategic decision-ma...

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$68K - $168K *

Transform political engagement by driving software sales within a designated U.S. territory. Build relationships with Democratic officials and campaign professionals while managing outreach and client...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the charge in shaping and expanding bridge design services across New England. Provide strategic direction, oversee project delivery, mentor staff, and strengthen client relationships to enhance...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$84K - $103K *

Shape the future of startup financing by connecting innovative companies with vital capital solutions. Collaborate with founders and investors to develop tailored fundraising strategies and enhance th...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$160K - $175K *

Shape the strategic vision for data products, leading a high-performing team to drive data-informed decisions and enhance product strategy. Collaborate cross-functionally to establish data governance...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Unlock potential by leading strategic account management initiatives, driving customer satisfaction and revenue growth through effective relationship building and expansion strategies in a dynamic ent...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Transform airport advertising environments by conducting site visits, developing signage concepts, and collaborating with design teams. This role combines hands-on fieldwork with creative design to en...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$125K *

Transform customer experiences as a key advocate and technical partner, driving onboarding, adoption, and success for Enterprise clients while collaborating across teams to ensure optimal outcomes and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$119K - $221K *

Support dynamic legal processes in tech sales by negotiating complex agreements. Collaborate with cross-functional teams, manage high volumes of transactions, and drive legal department initiatives wh...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$67K - $99K *

Lead the charge in enhancing business resilience by reviewing recovery plans, coordinating testing, and supporting incident management to ensure operational continuity during disruptions. Engage with...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Join a team that's dedicated to operational excellence and employee development. As a Supervisor, you'll lead daily operations, manage performance, and ensure compliance while fostering a collaborativ...

Chesterfield, MORemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Unlock potential by leading the Oracle MFCS merchandising workstream, driving design and delivery for a seamless omnichannel experience. Collaborate with teams to optimize processes and ensure success...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$140K - $180K *

Elevate your career by leading civil engineering teams in delivering innovative site and land development solutions across the Midwest. Drive project success through mentorship, technical guidance, an...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$162K - $243K *

Join a team that's dedicated to advancing clinical trials through strategic oversight and collaboration. Lead project management efforts globally, ensuring quality, cost, and timeline objectives are m...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$71K - $119K *

Elevate your career by developing innovative BI solutions that enhance reporting workflows and support decision-making in healthcare education. Collaborate with stakeholders to modernize reporting and...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $120K *

Accelerate progress at the intersection of media and healthcare by leading integrated planning and strategy for pharmaceutical clients. Drive impactful engagement initiatives while mentoring a talente...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$70K - $95K *

Join a team that's driving business success by building relationships and selling comprehensive HR solutions to small and midsize companies. You'll manage your own pipeline, engage with decision-maker...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.