Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$128K - $170K *
Optimize financial strategies and drive growth initiatives as a trusted advisor to leadership. Engage in M&A analysis, pricing strategy, and market insights to enhance decision-making in a dynamic Saa...
1 week ago
Strategy and Operations Physician Enterprise Clinical SME
$125K - $235K *
Drive operational excellence in healthcare by leading transformative initiatives, optimizing workflows, and enhancing provider productivity. Collaborate with teams to deliver data-driven solutions tha...
1 week ago
$95K - $115K *
Help us transform business processes by designing and implementing innovative Power Platform solutions. Collaborate with stakeholders to automate workflows, enhance data visualization, and improve ope...
1 week ago
Principal Product Manager- Activation
$190K - $210K *
Transform the owner activation journey by streamlining processes from agreement to live listing. Drive metrics on activation rates and retention while collaborating with teams to enhance onboarding ef...
1 week ago
$100K - $120K *
Transform client engagement by leveraging Instructure products to enhance learning outcomes. Collaborate with stakeholders to implement best practices, drive adoption, and support educational initiati...
1 week ago
Senior Structural Engineer-Bridge
$88K - $154K *
Join a team that's redefining bridge engineering by delivering innovative designs and solutions. Collaborate on diverse projects, ensuring structural reliability and efficiency while enhancing your ex...
1 week ago
$79K - $99K *
Elevate your career by executing and advancing a dynamic organic social strategy. Collaborate with cross-functional teams to create engaging content that resonates with audiences and drives brand rele...
1 week ago
Transaction Management Director - Healthcare
$175K - $220K *
Shape the future of healthcare real estate by leading a dynamic transaction management team. Oversee negotiations, staff development, and strategic planning to drive client success and enhance operati...
1 week ago
Dental Field Trainer - Chicago
$80K - $95K *
Drive impactful training and coaching for dental practices, enhancing adoption of digital workflows and intraoral scanning. Collaborate with clinicians and leaders to ensure operational readiness and...
1 week ago
$170K - $230K *
Join a team that's redefining SoC design by owning subsystem development, integrating third-party IP, and optimizing PPA for next-gen architectures. Contribute across all design stages and drive impac...
1 week ago
Development Technical Lead (Technology)
$108K - $130K *
Lead the charge in architecting enterprise application integration solutions. Collaborate with Agile teams to create technical specifications, establish coding standards, and mentor developers while d...
1 week ago
Senior Sales Compensation Analyst - Software Sales
$110K - $130K *
Drive sales performance by managing comprehensive compensation strategies that align with company goals. Collaborate across teams to design and implement effective plans, analyze data trends, and ensu...
Reposted 1 week ago
$63K - $100K *
Champion patient recovery by evaluating and implementing tailored care plans. Collaborate with healthcare teams to enhance functional outcomes and ensure quality rehabilitation services across diverse...
1 week ago
Account Manager, DNA Synthesis - SouthEast
$100K - $120K *
Drive revenue growth by managing key customer relationships and delivering accurate forecasts. Collaborate with teams to support product development and ensure compliance with industry standards while...
1 week ago
Senior Electrical Engineer | Kansas City, MO
$95K - $115K *
Champion innovative electrical design solutions for complex projects, collaborating with multidisciplinary teams to enhance healthcare and institutional environments while ensuring high-performance, e...
1 week ago
$80K - $95K *
Drive strategic credit underwriting and risk assessment processes while mentoring junior team members. Collaborate with various stakeholders to enhance portfolio management, ensure compliance, and del...
Reposted 1 week ago
Associate, Strategic Finance & Corporate Development
$115K - $140K *
Reimagine financial strategy as you drive analytical rigor and strategic clarity in a high-impact role. Collaborate with cross-functional teams to support growth initiatives and shape the future of a...
1 week ago
$164K - $262K *
Take ownership of software architecture and development to create scalable, user-centric applications. Lead comprehensive development initiatives while optimizing performance and mentoring engineers i...
Reposted 1 week ago
Senior System Software Engineer - Datacenter Power Management
$224K - $431K *
Innovate cutting-edge software for data center power management, spanning architecture, firmware, and AI workloads. Drive product lifecycle from design to deployment, enhancing performance and energy...
1 week ago
$86K - $99K *
Champion aggressive sales growth by building strategic relationships and generating leads in the insurance housing sector. Drive market share expansion through effective communication and innovative s...
1 week ago
$110K - $130K *
Empower your career by driving strategic sales initiatives within large healthcare organizations. Own the full sales cycle, build executive relationships, and position a leading clinical collaboration...
1 week ago
Senior Vice President, Human Resources and Safety
$200K - $230K *
Lead the charge in shaping a people-first culture by aligning HR strategies with organizational goals, enhancing talent development, and fostering a collaborative environment across multiple sites and...
1 week ago
$73K - $90K *
Partner with us to provide technical sales support, develop customer relationships, and drive revenue growth in Military, Aerospace, and Government sectors. Collaborate across teams to deliver solutio...
1 week ago
Signal Processing Specialist Field Applications Engineer (FAE)-West Region
$166K - $266K *
Lead the charge in delivering advanced signal processing solutions as a trusted advisor. Collaborate with customers and teams to drive innovation in communications, aerospace, and AI applications, ens...
1 week ago
Lead Director - Network Core Infrastructure Operations
$144K - $288K *
Engage in a pivotal leadership role overseeing core network infrastructure operations. Drive stability, performance, and security across WAN and LAN environments while mentoring a skilled team and man...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.