Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$155K - $175K *

Champion employee relations by leading a multi-site team, driving strategic oversight, and ensuring effective resolution of workplace issues while partnering with legal and HR functions to maintain co...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Transportation

$180K - $210K *

Drive strategic growth and operational excellence in IT program management, overseeing federal contracts and leading Agile teams to enhance supply chain solutions for the Department of Veterans Affair...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$80K - $120K *

Transform claims management by leveraging expertise in commercial casualty claims, focusing on product and premises liability. Collaborate with a dedicated team to deliver exceptional outcomes while m...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$180K - $220K *

Elevate your career by leading global marketing strategies that drive demand generation, enhance brand positioning, and support revenue growth in the healthcare technology sector. Collaborate with cro...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Healthcare

$75K - $123K *

Lead the execution of Clinical Validation Audit quality programs, managing a team to ensure compliance with standards and client expectations while driving continuous improvement and operational effic...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$200K - $260K *

Unlock potential by driving new business sales in the Fintech sector, leveraging industry expertise to cultivate strategic relationships and deliver tailored solutions that meet client needs across No...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Business Services

$75K - $107K *

Unlock potential by delivering impactful training experiences that enhance audit quality and accuracy. Collaborate with clinical experts to translate complex guidelines into engaging learning material...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$93K - $154K *

Transform claims analysis by leveraging deep operational insights to identify patterns and anomalies. Collaborate with cross-functional teams to develop advanced data mining capabilities that enhance...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Business Services

$76K - $123K *

Optimize resident care by leading the MDS process, ensuring compliance with regulations, and collaborating with the interdisciplinary team to enhance quality outcomes and care plans for residents in a...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$64K - $103K *

Champion quality care by leveraging your nursing expertise to assess, coordinate, and deliver comprehensive services for residents, ensuring their physical and psychosocial needs are met within a coll...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$74K - $118K *

Elevate nursing care standards by overseeing staff and ensuring compliance with regulations. Lead daily operations, support resident care, and foster a safe environment while maintaining high-quality...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$76K - $123K *

Lead the charge in clinical education by coordinating training programs, evaluating needs, and ensuring compliance with standards for clinical care team members across multiple sites, fostering a cult...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Elevate your career by driving sales growth in the Advanced Wound Care market. Manage key accounts and foster relationships with healthcare professionals to enhance product adoption and meet sales tar...

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$131K - $209K *

Engage with teams to deliver comprehensive AI enablement programs, designing tailored learning paths and fostering a culture of proficiency across all departments. Collaborate closely with HR to integ...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Build strategic partnerships and drive growth in distribution channels across North America. Focus on relationship management, revenue growth, and channel enablement to enhance business performance an...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Energy & Utilities

$125K - $150K *

Support site leadership by spearheading financial strategies and governance, managing a high-performing finance team, and ensuring compliance while driving insightful analysis and operational efficien...

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$168K - $280K *

Optimize financial planning and analysis processes, driving strategic initiatives and enhancing reporting capabilities. Collaborate with leadership to deliver insights that support company-wide alignm...

RemoteRemote

Today

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$268K - $368K *

Unlock potential by leading global labeling strategy and operations, ensuring compliance and alignment across product lifecycles. Collaborate with cross-functional teams to drive effective labeling ne...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$83K - $107K *

Join a dynamic team to enhance patient care through interdisciplinary collaboration, psychosocial assessments, and resource development. Lead initiatives that empower families and improve health outco...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$190K - $305K *

Join a team that's shaping healthcare by providing legal guidance on regulatory matters, employee benefits, and AI initiatives. As a senior contributor, you'll lead complex reviews, manage risks, and...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$162K - $192K *

Lead strategic sales initiatives and manage P&L for MCC, driving growth through vendor contracts and financial oversight while executing the Commercial Strategic Plan and ensuring alignment with site...

Today

  •   8 - 10 years exp.  •   Food & Beverages

$155K - $170K *

Lead the charge in shaping enterprise business solutions through hands-on architecture and delivery in Microsoft Dynamics 365 Finance & Operations, focusing on integration, process optimization, and o...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Staffing

$140K - $150K *

Lead the charge in nationwide Cybersecurity Disaster Recovery and Contingency Planning initiatives, providing strategic oversight and technical expertise to enhance organizational resilience and ensur...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Staffing

$105K - $127K *

Champion transformative patient experience strategies by leveraging data insights to drive high-impact initiatives. Collaborate with C-suite executives and healthcare providers to enhance operational...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the development of enterprise-grade applications using Java, Python, and AI technologies. Collaborate with cross-functional teams to design and implement robust software solutions in a dynamic, A...

Today

  •   5 - 7 years exp.  •   Staffing

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.