Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
21GRAMS- Senior Project Manager
$110K - $115K *
Join a team that's redefining healthcare project management. Lead integrated initiatives, mentor talent, and drive excellence across diverse campaigns while fostering collaboration and innovation in a...
1 week ago
Senior Director, Real Estate & Workplace Strategy
$190K - $210K *
Advance our real estate strategy by leading portfolio planning, workplace design, and data analysis. Collaborate with internal teams and external partners to optimize office spaces, enhance employee e...
1 week ago
Senior Marketing Manager, Lifecycle & Growth
$90K - $120K *
Join a dynamic team to drive customer activation and retention strategies across the prescription lifecycle. Collaborate cross-functionally to optimize customer journeys and deliver measurable growth...
Reposted 1 week ago
Engineering Manager, Partner Integrations
$225K - $265K *
Drive the development of seamless integrations for security platforms, leading a team to deliver high-quality, reliable products that enhance customer security stacks and ensure compatibility with evo...
1 week ago
Backend Engineer, Knowledge Graph (Rust)
$115K - $162K *
Develop and optimize backend features for a Rust-based graph data service, enhancing reliability and scalability while collaborating across teams to deliver impactful solutions for GitLab's platform...
1 week ago
General Superintendent - St Louis, MO
$90K - $110K *
Unlock your potential by leading on-site construction operations, ensuring safety, quality, and timely project completion. Collaborate with teams to manage resources, resolve issues, and drive success...
1 week ago
Practice Administrator Hospitalist
$80K - $95K *
Lead the charge in optimizing clinical and operational excellence across multiple ambulatory clinics, ensuring effective provider management, financial oversight, and patient satisfaction while drivin...
1 week ago
$150K - $200K *
Join us to drive AI integration by transforming client workflows into live agents. You'll manage the entire process from scoping to deployment, collaborating with teams to deliver impactful solutions...
1 week ago
Senior Analyst, Asset Based Lending Field Exam
$95K - $115K *
Lead the future of asset-based field examinations by delivering insightful analyses, evaluating financial controls, and ensuring compliance. Collaborate with clients to assess collateral values and mi...
1 week ago
Retirement Plan Sales Consultant
$90K - $110K *
Shape the future of retirement planning by partnering with advisors to drive growth in employer-sponsored plans. Utilize your expertise to provide consultative sales support, foster relationships, and...
1 week ago
Field Consultant, CLESS (Construction Defect)
$108K - $200K *
Champion the resolution of complex commercial casualty claims by delivering exceptional customer service, conducting thorough investigations, and collaborating with defense counsel to ensure fair outc...
1 week ago
Director, Capital Formation High Net Worth
$160K - $200K *
Lead the charge in capital formation by raising equity from high-net-worth investors, ensuring timely funding for real estate deals. Build and coach a high-performing team while architecting a vibrant...
1 week ago
$80K - $95K *
Analyze and enhance budget processes within a federal financial division, ensuring accurate reporting and system improvements. Collaborate with activity centers to develop operating budgets and implem...
1 week ago
Regional Director of Specialty Operations
$110K - $130K *
Elevate specialty hospital operations by providing strategic leadership, enhancing workflows, and driving financial performance across multiple facilities. Collaborate with veterinary leaders to optim...
1 week ago
Production Commercialization Manager
$80K - $95K *
Accelerate product launches by coordinating cross-functional teams, managing timelines, and ensuring compliance with quality standards. Drive the stage-gate process and maintain a unified project mana...
1 week ago
Product Manager (Public Safety Software) - Remote
$100K - $120K *
Join a dynamic team to drive product strategy and execution for public safety software. Collaborate across functions to deliver mission-critical solutions that enhance community safety and support eme...
Reposted 1 week ago
Principal Technologist - AI and Data Center Networking
$160K - $200K *
Shape the future of data center networking as a Principal Technologist, leading complex pre-sales engagement and architecture for AI infrastructure. Collaborate with top industry players to innovate s...
Reposted 1 week ago
Senior Environmental Planner - Transmission focused
$95K - $115K *
Lead the charge in environmental planning for energy projects, managing compliance and permitting efforts across multiple jurisdictions. Collaborate with teams to deliver innovative solutions while fo...
1 week ago
$110K - $130K *
Champion technical solution design and deployment readiness, translating customer needs into secure, scalable architectures. Collaborate with engineering and cybersecurity teams to ensure successful t...
1 week ago
Staff Software Engineer, Image Build & Release
$229K - $260K *
Drive the technical direction for building and delivering containerized applications, ensuring reliability and security across deployments. Collaborate with teams to enhance automation and mentor engi...
1 week ago
Regional Sales Manager - Southeast
$140K *
Drive regional sales success by leading a dynamic team, achieving revenue goals, and fostering collaboration. Utilize your expertise in capital medical equipment sales to mentor Territory Managers and...
1 week ago
Staff Software Engineer, OTA Services
$229K - $260K *
Lead the charge in designing and implementing a robust OTA update system, ensuring seamless deployment across diverse environments while mentoring engineers and driving technical excellence in distrib...
1 week ago
Regional Sales Executive- North America
$180K - $225K *
Join a team that's redefining semiconductor IP licensing. Drive complex sales cycles, engage with key stakeholders, and build long-term relationships that generate significant revenue in a fast-paced...
Reposted 1 week ago
$120K - $158K *
Champion operational excellence by leading facilities management across a multi-state portfolio. Drive strategic initiatives, optimize vendor performance, and implement scalable processes to support o...
1 week ago
Strategic Partnerships Manager
$100K - $120K *
Engage in strategic partnership management to drive growth and innovation, overseeing development, negotiation, and execution of pivotal alliances. Collaborate cross-functionally to ensure alignment...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.