Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$157K - $292K *

Elevate legal technology solutions by leading architecture design and integration with partners. Collaborate across teams to ensure scalable, secure offerings that meet customer needs while guiding a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Media

$147K - $274K *

Empower innovation by leading applied AI research initiatives that shape product features. Collaborate with cross-functional teams to translate complex problems into impactful AI solutions, mentoring...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$100K - $143K *

Lead the management of professional liability claims from inception to resolution, ensuring thorough investigation and effective outcomes while collaborating with various stakeholders to optimize clai...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $90K *

Elevate financial insights as a Senior Financial Analyst, partnering with leaders to drive strategic planning, budgeting, and reporting. Leverage your analytical skills to enhance operational performa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$68K - $120K *

Join us to provide essential support in grant and contract administration, ensuring compliance and timely submissions. Collaborate with faculty and staff to develop proposals and budgets while maintai...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $140K *

Drive product innovation by leading the development of AI-enabled solutions for public sector agencies, enhancing early childhood systems through strategic vision, technical architecture, and customer...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $110K *

Elevate the impact of early childhood development by managing and expanding the HELP product suite. Drive customer relationships, account growth, and new business development while supporting practiti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$96K - $115K *

Lead strategic hiring initiatives by partnering with senior leaders to source and secure top salaried and executive talent. Drive full-cycle recruitment, market intelligence, and candidate experience...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$64K - $109K *

Empower patient care by coordinating clinical support in a dynamic Pulmonary & Critical Care team. Collaborate with physicians to manage workflows and ensure high-quality treatment for patients with c...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$96K - $133K *

Join a team that's dedicated to delivering high-quality projects on time and within budget. As a key player, you'll coordinate efforts across departments, ensuring effective communication and resource...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$108K - $149K *

Advance the organization by establishing robust data and AI governance practices. Collaborate across teams to ensure compliance, integrity, and responsible usage of data and AI assets, supporting both...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead complex compensation initiatives, ensuring equitable pay programs while managing projects. Serve as a subject matter expert in various compensation areas and collaborate with teams to enhance org...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Unlock potential by joining a dynamic team as a Workers’ Compensation Claims Specialist. Leverage your expertise to investigate, resolve, and manage claims while ensuring compliance and delivering exc...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$79K - $125K *

Lead the charge in enhancing Employer Health Solutions products, driving market competitiveness through collaboration, strategic analysis, and innovative development. Support regulatory compliance and...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $115K *

Lead the charge in transforming complex business needs into impactful analytic products. Collaborate with stakeholders to design, develop, and maintain reusable semantic models that enhance decision-m...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $220K *

Lead the global Accounting and Treasury function, driving financial systems, reporting, and IPO readiness while building a scalable team to support international growth and operational complexity...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$165K - $215K *

Champion the evolution of Android features, driving product impact through collaboration and innovation. Own the development process from concept to deployment, ensuring high-quality user experiences...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$160K - $200K *

Join us to redefine retail marketing in the cannabis industry. Lead strategy, visual merchandising, and shopper engagement initiatives to enhance brand presence and drive sales across U.S. dispensarie...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$130K - $140K *

Shape the future of AI-driven financial advice by designing intuitive, impactful products. Collaborate closely with PMs and engineers to create solutions that enhance user experience and drive results...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$200K - $275K *

Elevate data strategy and reporting for the System Performance Organization, transforming complex robotics data into compelling narratives for executive stakeholders while fostering team growth and al...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Transportation

$85K - $100K *

Shape the future of air navigation by leading and training navigators in a dynamic flying squadron. Oversee training programs, evaluate performance, and ensure operational excellence in multi-engine a...

1 week ago

  •   15+ years exp.  •   Aerospace & Defense

$200K - $220K *

Lead strategic policy initiatives and public affairs to drive next-gen power infrastructure deployment with carbon capture. Engage stakeholders and influence regulatory frameworks to support sustainab...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$160K - $180K *

Collaborate with partners to build a robust technical foundation for channel sales. Enable engineers to independently deploy solutions, ensuring technical readiness and driving measurable success in p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $215K *

Unlock potential by architecting and managing robust data infrastructure, ensuring reliability and scalability while mentoring junior engineers and enhancing platform performance in a dynamic analytic...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Advance public safety software solutions by driving the product vision and roadmap for Records Management Software, optimizing features and ensuring alignment with customer needs, market trends, and t...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.