Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$140K - $190K *

Join a team that's dedicated to providing expert CFO Advisory Services, helping clients navigate financial planning, compliance, and strategic growth. Leverage your skills in a fast-paced environment...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$113K - $153K *

Engage as the Technology Workstream Lead, driving cross-functional execution and managing enterprise initiatives. Oversee planning, risk management, and stakeholder communication to ensure successful...

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$110K - $140K *

Join a dynamic team to lead financial forecasting, analysis, and strategic decision-making. Utilize advanced analytics and financial modeling to drive insights and support M&A initiatives while enhanc...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$130K - $176K *

Champion application portfolio management by leading teams, enhancing governance, and driving operational excellence to support strategic business objectives and improve application health across the...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$153K - $210K *

Strategize and enhance data integrity across extensive systems, ensuring all operational data is accurate and reliable for key clinical and financial workflows while enabling self-serve analytics for...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Drive investor relations by cultivating institutional partnerships, managing client expectations, and executing complex transactions in the renewable energy sector. Collaborate with teams to align str...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Drive financial modeling and analysis for renewable energy investments, supporting underwriting and valuation processes. Collaborate with cross-functional teams to evaluate project economics and deliv...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $145K *

Join a team that's passionate about enhancing digital commerce experiences. As a Senior Product Manager, you'll lead innovative solutions, collaborate with cross-functional teams, and drive product ex...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$224K - $356K *

Pioneer the development of advanced evaluation tools for Autonomous Vehicles, enhancing workflows and system performance. Collaborate with cross-functional teams to deliver scalable solutions that imp...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$168K - $322K *

Build and operate core infrastructure services for global AI platforms, developing secure cloud-native solutions and orchestrating automation to enhance reliability and scalability in a collaborative...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$158K - $185K *

Join a dynamic team dedicated to revolutionizing cardiac health through innovative sales leadership. Guide a team of Territory Managers, driving revenue growth and operational excellence across a desi...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $95K *

Transform engagement in legal education by managing relationships, driving program success, and supporting bar exam strategies across multiple states. Collaborate with schools and students to enhance...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$90K - $180K *

Empower growth through strategic business development and market expansion. Drive Zio platform adoption by establishing relationships with healthcare stakeholders and maintaining account performance w...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead multifamily transactions from sourcing to closing, ensuring disciplined execution and strategic alignment across teams. Drive outcomes through strong negotiation, relationship management, and a r...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$90K - $180K *

Accelerate progress at market expansion by driving adoption of innovative health technology. Engage with cardiologists and EPs to capture new business and enhance customer relationships in a dynamic s...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$107K - $160K *

Join a team that's dedicated to delivering exceptional financial services to tribal clients. Oversee general ledger preparation, financial reporting, and audit readiness while fostering strong client...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$75K - $100K *

Drive paid social strategy and execution for national clients, ensuring alignment with business objectives. Lead operations, optimize campaigns, and mentor team members while staying ahead of social m...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$200K - $240K *

Pioneer high-growth revenue strategies across the Americas. Lead a dynamic sales team, drive go-to-market initiatives, and engage with key stakeholders to achieve ambitious targets in the cybersecurit...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $218K *

Drive SAP Data & Analytics transformations, collaborating with teams to deliver innovative solutions that enhance client operations and support the journey to an autonomous enterprise. Engage with sta...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$110K - $218K *

Join a team that's transforming businesses through SAP Data & Analytics solutions. Leverage AI and industry insights to drive impactful ERP transformations, collaborating with clients to modernize pro...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$75K - $113K *

Empower patients by coordinating personalized hospice care, assessing needs, and collaborating with a dedicated care team to enhance quality of life and ensure compassionate support throughout the car...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$87K - $160K *

Unlock potential by leading strategic PLM engagements, transforming systems, and guiding clients through complex landscapes. Collaborate across teams to design scalable architectures that align with e...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$144K - $187K *

Accelerate customer success by leading complex implementations of cloud-native PLM and QMS solutions. Manage program execution, project governance, and customer accountability to ensure timely decisio...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Join us to drive new customer acquisition for ERP solutions in discrete manufacturing. This full-cycle sales role requires building relationships, managing complex sales processes, and achieving reven...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$157K - $292K *

Elevate legal technology solutions by leading architecture design and integration with partners. Collaborate across teams to ensure scalable, secure offerings that meet customer needs while guiding a...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.