Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$115K - $149K *

Champion efficient inventory and cost accounting processes, leading cross-functional collaborations. Drive accuracy in financial performance metrics while overseeing accounting operations in a dynamic...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$175K - $283K *

Champion regulatory excellence by leading CMC strategies for small molecule programs, ensuring compliance and driving successful submissions from early development through commercialization in a dynam...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive compliance excellence by leading a dynamic team focused on grant management, ensuring milestones are met and payment requests are executed efficiently while fostering cross-functional collaborat...

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$70K - $95K *

Grow your career with a remote role assisting clients in navigating retirement solutions. Leverage your financial expertise to build relationships and provide guidance, all while enjoying a supportive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$141K - $211K *

Transform clinical and revenue-cycle operations by leading cross-functional teams to optimize technology solutions, ensuring efficient charge capture and financial reporting while enhancing patient sa...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$163K - $214K *

Lead the charge in defining strategic market presence and network design. Drive investment decisions by analyzing demand, competition, and demographics to optimize facility configurations across multi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $120K *

Transform operational excellence by leading a portfolio of veterinary hospitals. Drive strategic initiatives, enhance team performance, and ensure alignment with business goals while fostering a cultu...

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$111K - $130K *

Grow a high-performing sourcing team while executing strategic initiatives across indirect spend categories. Collaborate cross-functionally to enhance supplier performance and drive operational effici...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$153K - $268K *

Empower your career by leading bio sample operations across clinical studies. Oversee end-to-end processes, ensuring compliance and quality while collaborating with cross-functional teams and external...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$73K - $127K *

Join our dynamic Outsourced Accounting Team to deliver tailored financial services, manage client accounts, and drive operational excellence. Collaborate with clients and team members to enhance their...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$120K - $145K *

Transform the contract lifecycle by leading agent-driven workflows, leveraging data insights to enhance product value and customer satisfaction. Collaborate across teams to innovate and deliver user-c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Champion the growth of a self-directed engineering team, shaping processes, technical direction, and compliance in a fast-paced, regulated environment. Balance hands-on coding with leadership to drive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $115K *

Join a team that's transforming food safety compliance through innovative SaaS solutions. As a Senior Account Executive, you'll drive sales growth by managing the full sales cycle and building strong...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Champion the execution of AI initiatives across the enterprise by overseeing project governance, planning, and cross-functional coordination, driving effective delivery from concept to measurable outc...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $145K *

Drive product strategy and modernization for merchant onboarding solutions, collaborating with cross-functional teams to enhance risk management capabilities and ensure market-leading standards in a d...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Engage in transformative leadership within a new construction division, overseeing project lifecycles from planning to execution. Drive operational excellence, foster team development, and ensure comp...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$90K - $115K *

Empower a high-performing team to enhance customer trial experiences, driving strategic initiatives and fostering collaboration. Lead with data-driven insights to optimize processes and ensure excepti...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $165K *

Elevate insider threat investigation capabilities by leveraging advanced analytics and risk assessment skills to support complex investigations and enhance organizational security posture against insi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$152K - $190K *

Accelerate growth by driving IoT solutions for mid-sized customers, managing complex sales cycles, and fostering relationships with key stakeholders to deliver impactful sensor data solutions...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $172K *

Unlock potential by leading product initiatives for 360e Facility Coding, collaborating with diverse teams to enhance customer experiences and drive business value through innovative solutions and eff...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$124K - $170K *

Unlock potential by leading cross-functional teams to innovate and enhance manufacturing processes. Drive product support, cost reduction, and technological advancements while ensuring robust supply c...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$126K - $210K *

Shape the future of procurement by leading strategic sourcing initiatives, optimizing technology spend, and fostering supplier relationships. Drive value through effective negotiation and collaboratio...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$102K - $171K *

Drive impactful medical drug strategies by leveraging healthcare expertise and data. Collaborate with cross-functional teams to enhance client solutions and support product development, ensuring effec...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$109K - $183K *

Optimize sourcing strategies and supplier relationships to enhance risk management, drive competitive pricing, and support strategic initiatives within Information Security and Technology. Lead comple...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Drive litigation strategy and outcomes in a dynamic P&C environment, leading a team to enhance operational effectiveness and improve policyholder experiences while managing diverse liability and cover...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.