Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $150K *

Lead the transformation of Customer Engagement and ERP systems, ensuring alignment with business goals. Drive improvements, manage deployments, and foster collaboration across teams to deliver effecti...

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$158K - $188K *

Join a team that's dedicated to driving growth in commercial banking by managing complex relationships in the AEC sector. Leverage your expertise to deliver tailored financial strategies and foster lo...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$158K - $188K *

Drive strategic growth by managing complex commercial banking relationships in the AEC sector. Leverage industry expertise to deliver tailored financial solutions and foster long-term partnerships, en...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$162K - $244K *

Join a team that's driving channel success by building strong partnerships, creating impactful business plans, and enhancing pipeline growth through strategic collaboration and support for regional pa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$64K - $128K *

Drive a secure environment by leading crisis response, managing theft prevention, and fostering a culture of safety. Collaborate with teams to enhance profitability while ensuring product availability...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Unlock your potential by designing and integrating advanced manufacturing controls systems. Collaborate across teams to enhance production efficiency and drive continuous improvement in a dynamic engi...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Lead the charge in defining and activating brand strategies across multiple channels, enhancing donor engagement and retention through innovative content and social communications while collaborating...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$106K - $160K *

Lead complex contract negotiations and drive strategic supplier relationships. Collaborate with stakeholders to assess risks, develop negotiation strategies, and enhance contracting practices while me...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$114K - $252K *

Unlock potential by leading software development initiatives, ensuring system integration, and guiding teams through agile methodologies to deliver high-quality solutions that meet customer requiremen...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $138K *

Lead the charge in clinical trial monitoring, ensuring adherence to protocols and regulatory standards while fostering collaboration and quality improvement across teams and sites...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead and execute regulatory strategies for multi-region clinical trials, ensuring compliance and timely submissions. Collaborate with project teams to manage risks and drive operational excellence thr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$122K - $150K *

Support the design and maintenance of a global virtual desktop environment, serving as the SME for troubleshooting and optimizing performance while collaborating across multiple complex production env...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$118K - $180K *

Join a dynamic team enhancing nuclear power plants through advanced engineering. Leverage your expertise in thermodynamics and fluid mechanics to drive power uprate projects, mentor junior staff, and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $152K *

Empower progress in environmental compliance by developing air permitting strategies for complex industrial projects. Collaborate with multi-disciplined teams to ensure adherence to air quality regula...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$132K - $174K *

Shape the future of environmental consulting by leading complex projects, fostering client relationships, and driving strategic initiatives. Collaborate with multidisciplinary teams to ensure excellen...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Energy & Utilities

$110K - $130K *

Elevate product execution by translating client needs into actionable requirements, collaborating with engineering and data science teams to deliver standardized measurement solutions across various c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$89K - $113K *

Transform data integrity by assisting in the analysis and cleansing of Enterprise Business Systems. Collaborate with teams to resolve anomalies and ensure compliance with DoD standards while supportin...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$77K - $105K *

Join a team that's dedicated to enhancing patient care through effective case management. You'll coordinate treatment plans, ensure quality outcomes, and facilitate safe discharges across multiple loc...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $205K *

Develop intuitive, user-friendly interfaces for advanced AI products, enhancing user experiences across various platforms. Collaborate with teams to create engaging, no-code solutions that simplify AI...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$88K - $105K *

Reimagine project management as you lead diverse MEP design operations, ensuring quality, timely delivery, and strong client relations across multiple sectors. Drive team performance while fostering p...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Technical Services

$125K - $150K *

Shape the future of product marketing by bridging product and go-to-market teams. Drive impactful messaging, enablement, and strategies that resonate with audiences, ensuring alignment in a fast-paced...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$115K - $150K *

Architect and streamline cloud network infrastructure. Support robust security and connectivity across Azure, OpenShift, and SASE platforms. Collaborate with cross-functional teams, ensuring optimal p...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $158K *

Join a dedicated team to lead the software development efforts for private brand growth. Empower engineers to create innovative solutions while overseeing project delivery and fostering a collaborativ...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Join a team that's leading high-value capital projects, focusing on complex renovations and new construction. You'll drive strategy, oversee delivery, and ensure financial performance while mentoring...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$142K - $178K *

Lead the charge in strategic financial planning, driving insights and forecasts that shape growth. Collaborate with executives and teams to enhance financial models and reporting processes in a dynami...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.