Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Construction Project Manager - Bush Construction (St. Louis, MO)
$80K - $95K *
Drive successful housing projects from inception to completion, ensuring adherence to design, budget, and schedule. Collaborate with clients and teams to enhance commercial housing expertise and expan...
1 week ago
Senior Manager, Clinical Operations Programs
$160K - $190K *
Join a team that's driving excellence in clinical operations, leading global studies and ensuring regulatory compliance. Utilize your project management expertise to enhance efficiency and maintain hi...
Reposted 1 week ago
$63K - $104K *
Join a team that's dedicated to delivering exceptional patient care by performing vital laboratory tests across multiple disciplines. Make an impact in healthcare while collaborating in a fast-paced e...
Reposted 1 week ago
$71K - $106K *
Support our oncology team by assessing patient needs, managing care plans, and ensuring optimal outcomes through collaboration with multi-disciplinary teams. Your expertise is key in providing compass...
Reposted 1 week ago
$135K - $145K *
Innovate data solutions by building and maintaining robust pipelines that empower critical processes. Collaborate with engineers and stakeholders to enhance data reliability and efficiency in a high-t...
1 week ago
Manager, Enterprise Sales Engineering - New York
$135K - $160K *
Champion growth by leading a dynamic team of sales engineers, collaborating with sales leadership to drive technical strategies and enhance customer value in the Enterprise sector. Stay ahead of indus...
1 week ago
Forward Deployed Engineer II (Remote, US)
$160K - $180K *
Accelerate progress at the forefront of technology by owning deployments, solving complex problems, and driving strategic initiatives for major clients. Collaborate closely with engineering and custom...
1 week ago
RN- Maternal Newborn- Weekend Nights
$71K - $106K *
Elevate healthcare at our maternal newborn unit, ensuring exceptional patient care through hands-on assessment, education, and collaboration with multidisciplinary teams in a dynamic environment focus...
Reposted 1 week ago
$87K - $109K *
Transform public-sector auction services by building relationships with key decision-makers. Drive business growth through strategic outreach, presentations, and consultative selling, ensuring long-te...
1 week ago
$80K - $95K *
Join a dynamic team as you drive client success through deep product expertise, fostering relationships that enhance adoption and deliver measurable business value across multi-site manufacturing orga...
1 week ago
Tenured Associate Professor of Human Factors & MSHF Program Chair, Worldwide Campus (Remote Role)
$100K - $120K *
Lead the charge in advancing human factors education and research as a tenured associate professor and program chair. Drive curriculum development, foster student engagement, and contribute to a colla...
1 week ago
Director, Sustainability Regulatory Advisory
$200K - $230K *
Shape the future of sustainability advisory by leading complex engagements, driving business growth, and delivering high-quality regulatory compliance solutions in a rapidly evolving ESG landscape...
1 week ago
Account Executive, Audit Manager
$100K - $170K *
Champion the growth of Audit Manager by driving sales in the healthcare sector. Leverage your expertise in medical billing and coding to engage revenue cycle leaders, manage the sales pipeline, and de...
1 week ago
Channel Development Manager, Lenovo
$100K - $120K *
Empower our channel development as you engage customers to activate solutions, becoming a key resource and expert in Absolute technology. Collaborate with sales teams to drive activations, renewals, a...
Reposted 1 week ago
Commercial Sales Engineer- New York
$110K - $130K *
Drive technical sales success by leveraging your expertise in cloud technologies and advanced sales frameworks. Collaborate with teams to craft tailored solutions for startup and midmarket clients, en...
1 week ago
$110K - $130K *
Transform organizational communication by building editorial standards, streamlining workflows, and enhancing writing quality across diverse teams. Collaborate with leaders to ensure clarity, purpose...
Reposted 1 week ago
RN - Clinic Triage Nurse - Diabetes & Endocrinology Center
$64K - $96K *
Elevate patient care by triaging and assessing needs over the phone. You’ll collaborate with a multi-disciplinary team to provide quality care, guiding patients to appropriate resources while ensuring...
Reposted 1 week ago
$150K - $180K *
Unlock potential by driving complex sales into Fortune 2000 accounts, engaging with key stakeholders in compliance and technology. Shape the future of AI in enterprise solutions while achieving ambiti...
1 week ago
$140K - $170K *
Drive growth by managing key customer relationships in the Southeast and West Coast. Lead strategic initiatives, pricing, and account development while collaborating with dedicated coordinators to enh...
1 week ago
Senior Principal - Data Estate Simplification & Modernization Program (Banking)
$210K - $256K *
Accelerate progress at a leading consulting firm by managing a large-scale data transformation program. Oversee governance, stakeholder alignment, and change management across multiple workstreams to...
1 week ago
$66K - $102K *
Elevate your career by joining our consulting team to design and implement SAP PP/QM solutions, driving value for clients through innovative strategies and expert knowledge transfer in a dynamic, glob...
1 week ago
SAP SF Recruitment and Onboarding Consultant
$73K - $102K *
Bring your expertise to enhance ERP solutions by collaborating with stakeholders, customizing modules, and ensuring seamless integration while maintaining compliance and performance standards...
1 week ago
$83K - $93K *
Join a team that's dedicated to servicing and repairing CNC machine tools. Perform complex diagnostics and repairs, ensuring operational excellence through customer interaction, advanced troubleshooti...
Reposted 1 week ago
Senior Director, Developer Relations
$275K - $405K *
Transform developer engagement by leading a global team that inspires and equips developers. Drive strategic initiatives, foster community, and enhance Twilio's presence in the developer ecosystem thr...
1 week ago
$71K - $106K *
Lead the charge in delivering exceptional patient care as a Charge Nurse in a high-acuity Emergency Services department, ensuring safety, quality, and effective communication among healthcare teams wh...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.