Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$80K - $95K *
Join a team that's transforming client websites into growth engines through data-driven conversion rate optimization. Collaborate with cross-functional experts to analyze user behavior, run A/B tests...
1 week ago
$100K - $120K *
Optimize customer engagement by leveraging technical expertise to drive sales, enhance relationships, and expand market share for pneumatic and control systems. Collaborate with teams to deliver tailo...
1 week ago
Senior Manager / Associate Director, Medical Information
$165K - $210K *
Drive the Medical Information strategy for infigratinib, ensuring high-quality, compliant content delivery. Collaborate cross-functionally to support scientific exchange and operational excellence in...
1 week ago
$80K - $95K *
Transform customer relationships and drive revenue growth by managing account strategies, identifying upsell opportunities, and collaborating with cross-functional teams to enhance product adoption an...
Reposted 1 week ago
Cost Accounting Manager (Hybrid)
$112K - $150K *
Join a team that's dedicated to enhancing cost control and financial reporting in manufacturing. This role involves executing monthly closings, variance analysis, and collaborating with cost managers...
Reposted 1 week ago
$120K - $175K *
Pioneer insights at the intersection of Sales, Marketing, and CS by owning and enhancing analytical infrastructure to generate decision-ready insights that drive growth in a dynamic, fast-paced enviro...
Reposted 1 week ago
$88K - $105K *
Elevate your career by leading high-level accounting operations, mentoring teams, and collaborating across divisions to enhance financial integrity and operational efficiency in a dynamic federal envi...
1 week ago
Sr. Advisor, Molecular Pharmacology - Neuroscience
$129K - $231K *
Reimagine drug discovery as you lead molecular pharmacology efforts in neuroscience. Collaborate across teams to develop strategies, interpret data, and advance innovative therapies for sleep-wake dis...
Reposted 1 week ago
$80K - $105K *
Join a specialized team to evaluate biological research, ensuring safety against misuse. Utilize your expertise to distinguish legitimate science from potential threats, contributing to AI safety and...
1 week ago
Senior Staff Engineer, Design Systems
$135K - $160K *
Join a dynamic team to architect and implement a next-gen Design System, ensuring consistent, accessible experiences across products. Collaborate with cross-functional teams to drive technical alignme...
1 week ago
$110K - $130K *
Transform pharmacy operations by leading a dynamic team, ensuring clinical safety and quality in a fast-paced environment. Drive performance, optimize workflows, and foster a culture of excellence and...
1 week ago
Director, Access Strategy & Marketing
$201K - $251K *
Elevate access strategies and marketing initiatives for oncology products, focusing on non-clinical value propositions. Collaborate cross-functionally to ensure successful product launches and effecti...
1 week ago
Executive Director Access Services - Immunology
$255K - $424K *
Lead the development and execution of Immunology access services strategy, ensuring seamless patient and provider experiences. Collaborate cross-functionally to enhance reimbursement initiatives and d...
1 week ago
$142K - $160K *
Champion privacy compliance in the Neurology therapeutic area, providing expert guidance on data protection, contract negotiation, and training. Collaborate with cross-functional teams to ensure adher...
1 week ago
Territory Sales Representative, Dental Implants
$70K - $150K *
Drive growth in oral surgery practices by building relationships, pursuing new sales opportunities, and achieving targets. Leverage your sales expertise to deliver exceptional customer service and sup...
1 week ago
Traveling Senior Superintendent - Nationwide
$93K - $203K *
Manage and oversee construction site operations, ensuring timely project completion and adherence to safety standards. Collaborate with subcontractors and teams to deliver high-quality results across...
Reposted 1 week ago
$93K - $125K *
Manage a dynamic logistics engineering team to oversee comprehensive product support analysis, develop sustainment strategies, and maintain technical documentation to meet customer needs and enhance o...
Reposted 1 week ago
Project Director-Industrial Construction
$185K - $235K *
Lead the charge in executing large-scale heavy industrial construction projects, ensuring safety, quality, and client satisfaction while managing budgets, schedules, and team performance from award th...
1 week ago
Traveling Director - Do What You Love to End ALZ
$71K - $90K *
Champion the future of fundraising by inspiring communities and building strategic partnerships. Leverage your sales expertise to drive peer-to-peer fundraising initiatives, making a lasting impact on...
1 week ago
Patient Access Liaison - Remote
$110K - $130K *
Join us to minimize access barriers for patients and providers, executing market access plans across multiple states. Collaborate with healthcare professionals to resolve reimbursement issues and enha...
1 week ago
$150K - $350K *
Join a team that's building scalable, high-performance backend systems using TypeScript. Collaborate across functions to optimize trading solutions and tackle complex challenges in the blockchain spac...
1 week ago
Oracle Utilities Field Service Solution Architect
$120K - $145K *
Empower your career by leading the design and implementation of Oracle Field Service solutions for utility organizations. Collaborate with stakeholders to enhance operational performance and customer...
1 week ago
Lead Data Engineer - Google Cloud & Azure Databricks (Kansas City)
$120K - $145K *
Accelerate progress at the forefront of data engineering by designing and implementing scalable data pipelines across multi-cloud environments, while mentoring a talented team and aligning technical s...
1 week ago
$108K - $130K *
Elevate your career by leading the design and development of embedded systems. Collaborate with cross-functional teams to enhance performance and security, ensuring robust solutions for vehicles and e...
1 week ago
Enterprise Customer Success Manager
$110K - $130K *
Unlock potential by overseeing a portfolio of enterprise accounts, fostering strategic partnerships, and driving user engagement to achieve measurable outcomes. Collaborate with internal teams to deli...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.