Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior Developer (AI / Agentic Solutions) | Remote | 6+ Months
$120K - $145K *
Empower innovation by designing intelligent AI agents and automation solutions. Collaborate with architects and stakeholders to implement cutting-edge Generative AI technologies for enterprise applica...
Today
$130K - $150K *
Optimize complex Salesforce implementations by leading cross-functional teams, managing project lifecycles, and ensuring successful client outcomes through effective communication and risk management...
Today
$80K - $90K *
Join a team that's dedicated to strategic program execution and risk mitigation. As a key analyst, you'll prepare and evaluate initiatives, collaborate across functions, and drive project success thro...
Today
$69K - $107K *
Champion client success by leveraging technical expertise to enhance platform value, optimize workflows, and drive measurable outcomes. Collaborate with cross-functional teams to deliver innovative so...
Reposted today
Staff Software Engineer, Infrastructure Foundations
$150K - $180K *
Join a team that's transforming multi-cloud infrastructure. As a Staff Software Engineer, you'll design and build a cohesive platform across AWS, GCP, and Azure, leading a multi-component system while...
Today
$223K - $255K *
Shape the future of patient access through science and evidence. In this field-based role, engage with national and regional payers, providing medical leadership and insights to inform access decision...
Today
Senior Engineering Manager, AI Platform
$150K - $180K *
Lead and develop a high-performing Applied AI team, driving the delivery of production AI systems while ensuring security, reliability, and operational excellence in healthcare applications...
Today
Registered Nurse - Evening / Nights Shift
$88K - $94K *
Join a team that's dedicated to serving our nation's heroes as a Registered Nurse. Make a meaningful impact while providing compassionate care in a supportive environment. Your skills will help enhanc...
Today
$85K - $100K *
Lead the charge in delivering comprehensive primary care for patients ages 2+, focusing on prevention and wellness. Collaborate with a dedicated team to manage health conditions and empower patients t...
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Growth Marketing Manager (AI-Enabled)
$85K - $95K *
Drive growth by identifying where US salon owners engage, creating impactful campaigns, and optimizing landing pages. Collaborate across teams to enhance Slick's presence in the beauty sector, leverag...
Reposted today
Test & Commissioning Specialist
$70K - $120K *
Elevate your career by supporting critical data center projects through startup, commissioning, and training activities. Collaborate with teams to ensure systems meet design intent and client expectat...
Today
$150K - $180K *
Unlock potential by leading technical solutions for enterprise SaaS implementations. Collaborate closely with clients to translate business needs into actionable technical designs, ensuring successful...
Reposted today
$82K - $100K *
Join a team that's redefining group sales in the flexible accommodations industry. Drive revenue through strategic relationship building and sales execution, while transforming how corporate and group...
Reposted today
Project Manager- Municipal Infrastructure
$125K - $145K *
Unlock potential by leading complex multi-disciplinary projects to achieve client goals, overseeing contracting, risk management, and deliverable production, while supporting program growth and commun...
Reposted today
$150K - $180K *
Champion the future of revenue operations by leading GTM infrastructure, analytics, and team scaling across multiple verticals. Drive strategic initiatives to enhance efficiency and revenue growth in...
Today
Senior Channel Specialist - Affiliate Marketing
$80K - $90K *
Take ownership of day-to-day campaign execution for paid search and affiliate marketing channels while driving performance optimizations and ensuring data integrity across multiple retail brands in a...
Reposted today
Government Services Territory Sales Manager - Ohio/Indiana Territory
$88K - $95K *
Elevate healthcare access by providing clinical support and driving sales growth across government accounts. Collaborate with VA and DoD partners to expand Cochlear's hearing solutions in the Ohio/Ind...
Today
Senior Enterprise Architect - Application and Data Architecture
$145K - $175K *
Lead the charge in shaping enterprise architecture by defining standards, guiding technology decisions, and developing roadmaps that align business priorities with scalable, secure solutions across ap...
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$95K - $115K *
Empower your career by leading risk management initiatives, ensuring compliance, and enhancing the Enterprise Risk Management framework. Collaborate with stakeholders to mitigate risks and drive strat...
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$80K - $95K *
Lead and inspire a team of 20 associates to enhance client experiences and support branch operations. Drive performance, talent development, and stakeholder partnerships while navigating a regulated e...
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Managing Director Global Delivery (Hub)
$125K - $295K *
Lead the charge in optimizing global delivery operations, ensuring seamless hub economics and resource allocation. Collaborate with finance and commercial teams to drive data-driven decisions and main...
Reposted today
$115K - $140K *
Join a team that's dedicated to transforming patient engagement through innovative marketing strategies. You'll develop and execute multichannel campaigns, crafting compelling content that drives enro...
Reposted today
Virtual Oncology Nurse Navigator
$85K - $100K *
Support the oncology care journey by delivering high-quality virtual patient care, coordinating services, and providing clinical support while building strong relationships with patients and clinical...
Reposted today
$120K - $145K *
Transform your career by leading the design and implementation of Pega applications. Collaborate with dynamic teams to deliver innovative BPM/BRE solutions, leveraging your expertise in system archite...
Reposted today
Nurse Practitioner- Hospice (Savannah, MO)
$95K - $143K *
Champion compassionate care by assessing patient needs and managing symptoms in a collaborative hospice team. Engage with families to enhance quality of life during end-of-life care, ensuring dignity...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.