Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$128K - $193K *

Lead the successful delivery of SAP implementation projects, ensuring client satisfaction and project profitability. Manage resources, timelines, and quality assurance while cultivating strong client...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $99K *

Transform hotel spend management by leading strategic consulting engagements, optimizing global programs, and delivering data-driven insights to enhance client performance and savings opportunities wh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$156K - $200K *

Champion the commissioning of hyperscale data centers by leading project teams, managing schedules, and ensuring compliance with technical standards. Collaborate with stakeholders to deliver successfu...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Technical Services

$114K - $182K *

Lead client engagements by leveraging SAP Finance expertise to optimize business processes, ensuring alignment with industry best practices while managing project deliverables and mentoring junior con...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $229K *

Empower clients by designing and implementing innovative SAP FSM solutions. Collaborate across teams to ensure successful project delivery, from discovery to go-live, while enhancing business processe...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Shape the future of AI evaluation by leading rigorous methodologies, collaborating with engineers, and mentoring teams to ensure accurate assessments that drive product innovation and market standards...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $190K *

Transform user engagement by owning product roadmaps, collaborating cross-functionally, and leveraging data to drive impactful solutions. Engage with customers to identify opportunities and validate h...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $112K *

Join a team that's redefining accounting operations. You'll manage day-to-day accounting, ensure accurate financial reporting, and collaborate closely with leadership to enhance processes as we grow...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $189K *

Lead the charge in developing and executing innovative marketing strategies for oncology products, collaborating with cross-functional teams to ensure successful launches and impactful customer engage...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$122K - $160K *

Transform the future of endpoint management by developing innovative solutions that enhance security and performance across diverse platforms, collaborating with a dynamic team to deliver impactful so...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$82K - $150K *

Lead the charge in expanding market presence by driving new customer acquisition and maximizing share of wallet within the dental implant community. Utilize a hunter mentality to identify opportunitie...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $150K *

Accelerate growth by driving new customer acquisition and expanding market share in the dental implant sector. Leverage a hunter mentality to convert competitive accounts and position value-oriented s...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$117K - $158K *

Unlock the potential of digital workspaces by leading VDI and EUC services opportunities. Collaborate with cross-functional teams to design, scope, and deliver innovative solutions that enhance user e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$117K - $158K *

Unlock potential by shaping and delivering AV and meeting room solutions at scale. This role combines technical expertise with project ownership, guiding clients from discovery to implementation while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Optimize supply chain strategies to enhance material availability and production readiness. Lead cross-functional teams in planning, inventory management, and compliance, driving continuous improvemen...

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$120K - $145K *

Join a team that's redefining product marketing in B2B SaaS. Collaborate closely with sales and product teams to craft compelling narratives, build essential sales tools, and drive successful product...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Transform operations by leading a manufacturing team to enhance safety, quality, and productivity. Drive continuous improvement initiatives while ensuring effective training and maintenance practices...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $115K *

Optimize client success by managing relationships, driving renewals, and aligning technology with client needs. Collaborate with cross-functional teams to deliver impactful solutions and ensure long-t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$250K - $500K *

Champion innovation by leading the migration to EKS, optimizing cloud infrastructure, and enhancing Kubernetes operations. Drive automation and CI/CD processes while ensuring high availability and per...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$123K - $160K *

Champion innovative cancer therapies by leading quality operations for apheresis and treatment centers. Collaborate cross-functionally to ensure compliance and support Kite's rapid expansion in CAR-T...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$145K - $210K *

Unlock potential by leading electrical substation projects, managing client relationships, and ensuring successful project delivery from concept to completion while driving business growth and maintai...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Explore an impactful leadership role driving sales strategies and team development in the PAH marketplace. Collaborate with cross-functional teams to enhance performance and foster relationships with...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$113K - $160K *

Champion the quantification of business impact from technology and transformation investments. Lead financial modeling and value realization efforts, translating insights into actionable recommendatio...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$80K - $95K *

Reimagine operational excellence by leading a regional team to optimize performance, enhance customer satisfaction, and ensure compliance. Drive financial success while fostering a safe and efficient...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$113K - $188K *

Shape the future of managed care by leading contract negotiations, performance monitoring, and strategic initiatives to optimize reimbursement and enhance payer relationships across healthcare service...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.