Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $130K *

Join a team that's redefining art leadership in live-service games. You'll empower Art Leads, enhance team operations, and ensure high-quality art delivery across our portfolio, fostering creativity a...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $145K *

Shape the future of product design by leading innovative initiatives, driving user insights, and enhancing user experiences across multiple platforms. Collaborate closely with product and engineering...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $140K *

Lead the strategy and execution of web growth initiatives, optimizing SEO, GEO, and AEO to enhance user experience and drive conversions. Collaborate with cross-functional teams to implement data-driv...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Unlock potential by leading financial operations and strategic analysis. Drive accuracy in reporting, enhance processes, and collaborate across teams to support informed decision-making while managing...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$68K - $126K *

Transform medical billing operations by leading a team to optimize systems, enhance service delivery, and drive continuous improvement through technology and structured practices, ensuring accountabil...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $115K *

Join a dynamic team as a Senior Project Planner, driving financial health and vendor coordination across multiple brands while ensuring project success through strategic planning and effective communi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $125K *

Join a team that's transforming the EV charging landscape by managing nationwide infrastructure projects. Oversee all phases from planning to execution, ensuring quality and compliance while collabora...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$80K - $95K *

Join a team that's shaping the future of utility-scale transmission projects. Oversee contractor activities, ensure quality installations, and foster strong relationships while managing project logist...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$152K - $179K *

Develop and implement security solutions to protect corporate infrastructure, user devices, and applications. Collaborate with IT and engineering teams to identify risks and enhance security measures...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Champion the full-cycle recruiting process, engaging top talent and enhancing candidate experiences while collaborating with hiring teams to meet organizational goals in a fast-paced, remote environme...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$155K - $317K *

Champion innovative legal service delivery by enhancing workflows, knowledge management, and technology adoption. Collaborate with attorneys and business teams to implement scalable solutions that imp...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$155K - $317K *

Transform legal service delivery by leading innovation initiatives, optimizing workflows, and enhancing knowledge management. Collaborate with attorneys and business teams to implement scalable soluti...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$155K - $317K *

Champion innovation in legal service delivery by enhancing workflows, knowledge management, and technology adoption. Collaborate with attorneys and business teams to implement scalable solutions that...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$160K - $200K *

Shape the future of corporate governance by leading complex legal matters in securities law and SEC reporting. Collaborate with stakeholders to provide strategic legal advice and manage regulatory ris...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$230K - $345K *

Lead the charge in shaping global Total Rewards strategies that attract, retain, and reward talent across diverse markets. Collaborate with senior leaders to build scalable, equitable programs while g...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $170K *

Lead the charge in defining and overseeing enterprise automation architecture, ensuring scalable, secure solutions across platforms like ServiceNow and Microsoft. Collaborate cross-functionally to ali...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Lead and guide project teams in implementing GRC and cybersecurity programs, ensuring the effectiveness of IT controls and compliance frameworks while mentoring junior staff and managing client relati...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$105K - $140K *

Elevate customer success and drive revenue growth by leading onboarding, managing relationships, and collaborating across teams to enhance the customer experience and maximize product adoption...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$76K - $128K *

Empower healthcare professionals and patients by providing expert education on diabetes management. Collaborate with sales teams to enhance territory growth and ensure optimal patient experiences whil...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $190K *

Champion product marketing initiatives by enhancing messaging, executing launches, and driving customer engagement. Collaborate with cross-functional teams to optimize the buying journey and deliver i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $136K *

Champion the administration and governance of AI platforms, ensuring secure and reliable operations across Microsoft 365 and emerging technologies. Collaborate with teams to enhance platform standards...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$170K - $250K *

Lead the charge in driving product commercialization and growth within your territory. Build trusted partnerships with healthcare professionals to enhance patient access and optimize market performanc...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$83K - $108K *

Transform the claims process by investigating and resolving non-litigated auto and general liability claims. Collaborate with stakeholders to ensure compliance and exceptional service while managing c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $135K *

Join a team that's redefining partner success by enhancing relationships and driving mutual growth. Utilize your expertise to streamline integrations and optimize partner experiences in a fast-paced a...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $144K *

Drive success by leading commissioning projects for critical facilities. Collaborate with diverse teams to ensure compliance, manage schedules, and execute testing of complex systems, all while mainta...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.