Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $100K *

Join a team that's driving growth by acquiring new customers and enhancing revenue through innovative solutions. Manage the full sales cycle while collaborating with cross-functional teams to ensure e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$91K *

Champion cross-functional programs that drive strategic outcomes, ensuring alignment with organizational priorities. Lead complex initiatives, manage risks, and foster stakeholder engagement to delive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$207K - $346K *

Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Transform the future of utility-scale solar projects by leading electrical operations, ensuring quality installations, and fostering strong team collaboration while managing contractor activities and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$91K - $115K *

Transform the candidate experience by sourcing top talent for sales and corporate roles. Collaborate with recruiters and hiring managers to build pipelines, utilizing advanced sourcing techniques and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Drive impactful AI and Agentforce delivery projects, managing customer relationships and internal initiatives. Leverage your strategic planning and analytical skills to oversee project execution and f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$210K - $260K *

Elevate IT operations by leading system integration and security strategy. Own the full tech stack, streamline processes, and enhance patient care through automation and effective team management in a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Optimize patient access workflows by aligning registration with revenue cycle needs. Collaborate with stakeholders to enhance eligibility processes and improve patient estimates, while mentoring IS st...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $260K *

Transform the workplace culture and integration of two organizations, ensuring support for clinicians and staff while enhancing benefits, compensation, and recruitment strategies to foster a unified m...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$159K - $286K *

Drive growth and profitability by cultivating executive alliances and delivering tailored solutions. Lead strategic account management, ensuring customer satisfaction while maximizing renewals and exp...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$103K - $176K *

Transform downstream marketing for cutting-edge medical devices. Drive product launches, develop compelling content, analyze market trends, and ensure regulatory compliance across global regions while...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Accelerate growth by leading global partnerships with PwC and GSIs. Drive revenue through strategic relationship management, co-selling initiatives, and market expansion while collaborating with cross...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Join a team that's redefining cybersecurity by implementing cutting-edge endpoint security solutions. Leverage your expertise to protect networks and data while collaborating with talented professiona...

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $200K *

Lead the charge in transforming business challenges into innovative solutions by leveraging your expertise in automation and integration. Collaborate across teams to enhance operational efficiency and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $185K *

Join a team that's redefining finance analytics by leading strategic forecasting and performance management. Drive impactful financial insights and methodologies while collaborating with leadership to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$96K - $135K *

Elevate your career as a strategic leader in paid social, driving growth through innovative strategies and high-performing teams. Leverage your expertise to optimize complex campaigns and foster colla...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$85K - $100K *

Join a team that's dedicated to delivering exceptional indirect tax solutions. You'll manage compliance, conduct research, and collaborate with clients across multiple jurisdictions, enhancing their t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$79K - $107K *

Join a team that's redefining energy solutions by designing innovative Battery Energy Storage Systems. Collaborate with engineers to deliver impactful civil designs that enhance land development proje...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$200K - $235K *

Empower organizational strategy and execution in Security & Technology, driving cross-functional initiatives and enhancing communication. Collaborate with leadership to optimize operations and inspire...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$199K - $274K *

Transform enterprise-scale engineering capabilities by leading the TORC function, fostering collaboration across security and operations, and delivering innovative solutions for risk and control manag...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$80K - $95K *

Support cybersecurity initiatives and build strong client relationships while collaborating with experts to deliver impactful solutions. Engage with business leaders to navigate risks and enhance secu...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $180K *

Lead the charge in strategic ERP advisory engagements, guiding clients through enterprise transformation and technology alignment to drive impactful change and enhance organizational readiness across...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$124K - $147K *

Join the charge in transforming financial analysis, providing insights that drive operational performance and profitability across manufacturing operations, while supporting strategic decision-making...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $150K *

Shape the future of safety in a dynamic environment by developing and enhancing EHS programs. Collaborate across teams to foster a culture of safety and compliance, ensuring adherence to regulations w...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$77K - $96K *

Manage and lead manufacturing operations, ensuring safety, efficiency, and quality. Drive continuous improvement initiatives while mentoring and developing team members. Collaborate with cross-functio...

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.