Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$90K - $140K *

Join a dynamic team to lead complex data management projects, blending Agile methodologies with technical expertise. Drive collaboration across healthcare analytics, ensuring successful delivery and s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $180K *

Lead a high-performing sales team to drive new logo acquisition and revenue growth in enterprise software. Develop strategies, foster collaboration, and engage executive customers to expand market sha...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the transformation of healthcare IT by managing ServiceNow projects, enhancing workflows, and ensuring seamless integration. Collaborate with cross-functional teams to deliver innovative solution...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Empower strategic acquisition and financial management for complex programs, interfacing with senior executives and ensuring alignment with agency objectives. Lead lifecycle planning and enhance progr...

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Join a team that's shaping strategic acquisition and program management for complex geospatial initiatives. Lead long-term planning, interface with senior executives, and ensure alignment with agency...

1 week ago

  •   15+ years exp.  •   Real Estate & Construction

$95K - $115K *

Transform acquisition processes by leading lifecycle support for GEOINT operations. Collaborate with diverse teams to develop essential documentation and ensure timely procurement actions, driving pro...

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$120K - $175K *

Join a team that's dedicated to managing complex professional liability claims, focusing on legal malpractice. Leverage your expertise to evaluate coverage, negotiate outcomes, and ensure timely reser...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$124K *

Advance patient care by providing comprehensive nursing services in a dynamic behavioral health setting. Collaborate with healthcare teams to assess, plan, and implement effective treatment strategies...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$126K - $236K *

Lead the charge in consumer engagement and growth strategy, driving awareness and deepening user connections across channels. Collaborate cross-functionally to optimize campaigns that inspire action a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$90K - $110K *

Join a team that's driving enterprise growth by building relationships and closing new business. This proactive sales role focuses on acquiring customers for innovative workforce development solutions...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$275K - $340K *

Drive growth by leading sales and customer success teams, refining strategies, and optimizing processes. Shape the commercial landscape while mentoring talent and ensuring high-value customer relation...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$199K - $269K *

Shape patient affordability strategies by leading a dynamic team focused on co-pay programs and innovative solutions. Collaborate cross-functionally to enhance operations, optimize performance, and dr...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$191K - $258K *

Shape the future of global safety by leading the development and submission of periodic aggregate safety reports. Drive compliance and collaboration across teams while managing a diverse global team t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive strategic pricing initiatives to enhance profitability and market positioning. Collaborate cross-functionally to analyze market dynamics and implement data-driven pricing strategies that support...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$85K - $100K *

Deliver advanced field service support for Promega instrumentation, ensuring installation, training, and repairs meet customer service standards. Collaborate with teams to enhance service documentatio...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Unlock potential by leading civil engineering projects, coordinating design and permitting while mentoring staff. Collaborate across diverse markets including healthcare, education, and commercial to...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$317K - $443K *

Engage with cross-functional teams to shape the design vision for search and feeds, leading a talented design group to enhance user discovery and community connections while driving growth and retenti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$95K - $115K *

Grow your career with a dynamic team focused on civil engineering and land development projects. Lead design and permitting efforts while cultivating client relationships and mentoring staff across di...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Join a team that's dedicated to enhancing automation solutions through troubleshooting, programming, and customer collaboration. Leverage your skills to improve machinery performance and ensure seamle...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead project engineering initiatives in testing, ensuring quality, compliance, and resource management. Drive continuous improvement and technical standards while collaborating with stakeholders to me...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$245K - $290K *

Champion strategic relationships in community oncology to enhance market access for innovative therapies. Drive account strategies, negotiate contracts, and collaborate cross-functionally to ensure op...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Shape the future of client solutions by leading technical discovery and crafting innovative data-driven strategies. Collaborate with sales teams to drive success and ensure seamless implementation of...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$92K - $110K *

Manage construction projects from planning to execution, ensuring safety, quality, and budget compliance. Collaborate with teams and clients to drive successful project delivery while maintaining stro...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Champion the deployment of cutting-edge AI systems in diverse environments. Collaborate with teams to ensure seamless installation and operation of hardware and software, while providing exceptional c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$84K - $127K *

Build a proactive maintenance culture by leading the team to optimize operations, reduce downtime, and ensure safety compliance in a dynamic manufacturing environment. Mentor staff while implementing...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.