Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$87K - $293K *

Innovate with cutting-edge AI solutions, leading architecture for enterprise systems. Drive multi-agent designs and collaborate with clients to enhance business value while managing engineering teams...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$132K - $302K *

Join a team that's driving innovation in ServiceNow solutions. As a Technical Architect, you'll lead enterprise transformations, mentor developers, and craft strategic solutions for Fortune 500 client...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$94K - $266K *

Join a dynamic team as a Functional Solution Architect, bridging architecture and execution in Wealth Management. Drive solution design, lead technical workstreams, and mentor junior members while nav...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$122K - $292K *

Drive transformative Workforce Access Management solutions, leading large-scale implementations and managing client relationships. Shape strategies aligned with Zero Trust principles while developing...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$100K - $170K *

Lead the charge in modernizing enterprise security by investigating and mitigating critical vulnerabilities. Collaborate across teams to drive risk reduction and enhance operational effectiveness in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$107K - $130K *

Engage in developing and maintaining scalable applications that meet business needs. Collaborate across teams, troubleshoot issues, and mentor staff while delivering quality code and documentation in...

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$120K *

Join a team that's driving impactful cross-functional initiatives by leading strategic delivery efforts. Leverage your project management expertise to align complex projects with enterprise priorities...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Drive regional sales growth by developing strategies, managing key accounts, and expanding market presence. Engage with K-12 leaders to enhance customer relationships and achieve sales targets while m...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$83K - $138K *

Lead the strategy and performance management for our mobile app and loyalty experience, driving athlete engagement and revenue growth through cross-functional collaboration and data-driven insights. O...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$112K - $132K *

Join a team that's shaping the future of autism care by building robust statistical methodologies. You'll analyze real-world clinical data, ensuring rigorous evaluation of outcomes and social validity...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Champion the growth of strategic travel partnerships by leading enterprise sales efforts, securing high-value accounts, and leveraging modern sales frameworks to drive commercial success in a fast-pac...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $108K *

Support clients by providing strategic IT guidance to maximize technology investments, ensuring alignment with business goals. Manage relationships, deliver reports, and enhance security posture while...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $175K *

Transform the Enterprise Data & AI landscape by leading strategy, execution, and governance. Drive cross-functional collaboration, optimize performance, and ensure alignment with business priorities f...

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$85K - $110K *

Unlock potential by leading end-to-end payroll processing across multiple US entities, ensuring compliance and accuracy while contributing to the evolution of a global payroll model within a dynamic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$180K - $220K *

Drive high-value sales and elevate team performance by mentoring Account Executives. Leverage your expertise in complex negotiations while managing a strategic pipeline to achieve personal and team su...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Transportation

$175K - $210K *

Transform business growth by leading strategic sales initiatives, enhancing market presence, and developing tailored solutions for corporate clients. Collaborate with cross-functional teams to drive r...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Drive product excellence by managing testing, documentation, and collaboration across teams. Engage with stakeholders to enhance solutions and ensure quality assurance for optimal deployment and suppo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $181K *

Transform data delivery by leading a team in Multi-Basis Accounting, driving strategic solutions and fostering collaboration across technology and business stakeholders to enhance operational efficien...

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$94K - $266K *

Elevate enterprise transformation by designing and delivering AI solutions that drive measurable business outcomes. Lead cross-functional teams, manage client relationships, and ensure quality in prod...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$94K - $293K *

Transform data engineering practices by leading modernization efforts, focusing on batch and streaming pipelines, AI-ready data, and governance frameworks to ensure trust and quality in data consumpti...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$130K - $241K *

Join a team that's redefining product management by driving AI-first digital solutions. Collaborate with diverse experts to transform strategic goals into impactful customer experiences, ensuring succ...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$80K - $85K *

Pioneer in claims management by analyzing complex auto bodily injury claims, ensuring timely resolutions while adhering to industry standards and client expectations. Collaborate with vendors and stak...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $241K *

Unlock potential by leading innovative digital product strategies that enhance customer experiences. Collaborate with diverse teams to drive AI-first solutions, ensuring successful execution from idea...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Develop and execute innovative strategies for employment law cases. Handle litigation tasks, mentor junior staff, and collaborate with a talented team to deliver exceptional legal services in a flexib...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Staffing

$87K - $157K *

Lead the execution of the Medicare Compliance Advisory program, ensuring adherence to CMS regulations. Collaborate with stakeholders to provide regulatory guidance, conduct audits, and enhance complia...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.