Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$110K - $130K *
Drive operational excellence by enhancing system reliability and automation. Collaborate with teams to minimize downtime, optimize performance, and implement innovative solutions that ensure high avai...
1 week ago
$110K - $130K *
Join a dynamic team to enhance system reliability and performance through automation, ensuring minimal downtime and optimal user experience while driving continuous improvements in a cutting-edge tech...
1 week ago
Associate Director, Omnichannel Marketing - Prostate Cancer
$170K - $213K *
Transform customer engagement by leading omnichannel marketing strategies, collaborating with cross-functional teams, and leveraging data insights to enhance HCP and patient experiences in the pharmac...
1 week ago
Biostatistical Programming Manager
$129K - $174K *
Lead a dynamic programming team to enhance data analysis strategies, ensuring high-quality biomedical data presentation while driving efficiency and innovation in a collaborative environment focused o...
1 week ago
Director of Business Development
$135K - $150K *
Champion growth by leading strategic business development initiatives, forging partnerships, and driving revenue expansion. Collaborate with executives to align goals and enhance market presence while...
1 week ago
$160K - $200K *
Drive strategic leadership in underwriting, enhancing performance and scalability across lending channels. Collaborate with cross-functional teams to ensure sound credit decisions and regulatory compl...
1 week ago
$88K - $105K *
Drive strategic growth by supporting project teams in budgeting, estimating, and scheduling throughout the preconstruction process, ensuring accuracy and efficiency in all phases of project delivery...
1 week ago
$110K - $130K *
Optimize clinical trial operations by leading cross-functional teams, managing vendor relationships, and ensuring compliance with regulatory standards to drive successful study execution and patient e...
1 week ago
Account Manager, Wound Reconstruction Solutions -- Los Angeles, CA
$95K - $115K *
Build strong relationships and drive sales for advanced wound care products in a defined territory. Achieve revenue targets through strategic planning, customer engagement, and exceptional service in...
Reposted 1 week ago
$120K - $145K *
Partner with us to drive customer success by implementing and expanding Teleport solutions. Leverage your expertise to enhance adoption, troubleshoot issues, and deliver tailored training, ensuring cl...
1 week ago
$100K - $120K *
Elevate revenue growth by driving sales of innovative traffic management solutions to government agencies. Collaborate with partners, identify opportunities, and build strong relationships to achieve...
1 week ago
$84K - $131K *
Engineer innovative web applications by leveraging Java and Spring Boot. Collaborate across teams to implement DevSecOps practices, ensuring secure, efficient delivery while integrating AI capabilitie...
1 week ago
Director, Rack Scale Software Architecture
$320K - $488K *
Join a team that's pushing the boundaries of innovation in rack-scale system software. Lead technical design efforts, collaborate with top industry players, and drive quality across a rapidly evolving...
Reposted 1 week ago
$110K - $130K *
Lead the charge in optimizing supply chain operations, ensuring alignment between production and inventory strategies while driving continuous improvements to enhance efficiency, service levels, and o...
Reposted 1 week ago
$80K - $95K *
Transform our supply chain operations by leading procurement and planning initiatives across production. Drive efficiency and optimize inventory management while collaborating with cross-functional te...
Reposted 1 week ago
Enterprise Software Account Manager
$100K - $110K *
Empower corporate veterinary groups by driving software adoption and growth. Collaborate with cross-functional teams to develop strategic partnerships, influence decisions, and enhance customer satisf...
1 week ago
$111K - $178K *
Unlock potential by leading patient access initiatives that enhance treatment journeys. Collaborate with stakeholders to navigate reimbursement challenges, improve patient outcomes, and drive operatio...
1 week ago
Technical Relationship Manager (Hybrid - JP Morgan Chase, New Jersey)
$110K - $130K *
Join a team that's dedicated to fostering strategic relationships with enterprise customers, ensuring successful adoption and optimization of technology solutions in the financial services sector whil...
1 week ago
Police Captain Patrol Division - WashU PD
$84K - $148K *
Drive community-oriented policing by leading patrol operations, managing personnel, and ensuring effective response strategies. Collaborate with university partners to enhance safety and engagement wh...
1 week ago
Construction SW Technical Specialist
$105K - $150K *
Transform construction project management by leveraging Autodesk solutions. Collaborate with clients to optimize workflows, deliver training, and ensure successful technology adoption, enhancing effic...
1 week ago
Staff Pharmacist - Infectious Diseases
$104K - $188K *
Join a dynamic team to prepare and label medications, ensuring accuracy and compliance while supervising pharmacy technicians and students in a fast-paced environment focused on patient care and safet...
1 week ago
Construction SW Technical Specialist
$105K - $150K *
Advance your career by leveraging your construction expertise to implement Autodesk solutions. Collaborate with clients to optimize project workflows, deliver training, and ensure successful technolog...
1 week ago
Construction SW Technical Specialist
$105K - $150K *
Join a team that's transforming construction project management through technology. Leverage your industry expertise to guide customers in adopting Autodesk solutions, enhancing workflows, and driving...
1 week ago
Architect - Platform Engineering - USA
$150K - $180K *
Join a dynamic team to architect and implement cutting-edge MLOps strategies, leveraging Google Cloud's AI/ML stack. Drive innovation in model lifecycle management and collaborate with cross-functiona...
1 week ago
$90K - $115K *
Lead the charge in enhancing customer support by guiding a skilled team of Support Engineers. Balance hands-on technical assistance with operational oversight to ensure a world-class experience for cl...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.