Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $130K *

Drive operational excellence by enhancing system reliability and automation. Collaborate with teams to minimize downtime, optimize performance, and implement innovative solutions that ensure high avai...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Join a dynamic team to enhance system reliability and performance through automation, ensuring minimal downtime and optimal user experience while driving continuous improvements in a cutting-edge tech...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$170K - $213K *

Transform customer engagement by leading omnichannel marketing strategies, collaborating with cross-functional teams, and leveraging data insights to enhance HCP and patient experiences in the pharmac...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$129K - $174K *

Lead a dynamic programming team to enhance data analysis strategies, ensuring high-quality biomedical data presentation while driving efficiency and innovation in a collaborative environment focused o...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $150K *

Champion growth by leading strategic business development initiatives, forging partnerships, and driving revenue expansion. Collaborate with executives to align goals and enhance market presence while...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$160K - $200K *

Drive strategic leadership in underwriting, enhancing performance and scalability across lending channels. Collaborate with cross-functional teams to ensure sound credit decisions and regulatory compl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$88K - $105K *

Drive strategic growth by supporting project teams in budgeting, estimating, and scheduling throughout the preconstruction process, ensuring accuracy and efficiency in all phases of project delivery...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Optimize clinical trial operations by leading cross-functional teams, managing vendor relationships, and ensuring compliance with regulatory standards to drive successful study execution and patient e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Build strong relationships and drive sales for advanced wound care products in a defined territory. Achieve revenue targets through strategic planning, customer engagement, and exceptional service in...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Partner with us to drive customer success by implementing and expanding Teleport solutions. Leverage your expertise to enhance adoption, troubleshoot issues, and deliver tailored training, ensuring cl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Elevate revenue growth by driving sales of innovative traffic management solutions to government agencies. Collaborate with partners, identify opportunities, and build strong relationships to achieve...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$84K - $131K *

Engineer innovative web applications by leveraging Java and Spring Boot. Collaborate across teams to implement DevSecOps practices, ensuring secure, efficient delivery while integrating AI capabilitie...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$320K - $488K *

Join a team that's pushing the boundaries of innovation in rack-scale system software. Lead technical design efforts, collaborate with top industry players, and drive quality across a rapidly evolving...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead the charge in optimizing supply chain operations, ensuring alignment between production and inventory strategies while driving continuous improvements to enhance efficiency, service levels, and o...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$80K - $95K *

Transform our supply chain operations by leading procurement and planning initiatives across production. Drive efficiency and optimize inventory management while collaborating with cross-functional te...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$100K - $110K *

Empower corporate veterinary groups by driving software adoption and growth. Collaborate with cross-functional teams to develop strategic partnerships, influence decisions, and enhance customer satisf...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$111K - $178K *

Unlock potential by leading patient access initiatives that enhance treatment journeys. Collaborate with stakeholders to navigate reimbursement challenges, improve patient outcomes, and drive operatio...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's dedicated to fostering strategic relationships with enterprise customers, ensuring successful adoption and optimization of technology solutions in the financial services sector whil...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$84K - $148K *

Drive community-oriented policing by leading patrol operations, managing personnel, and ensuring effective response strategies. Collaborate with university partners to enhance safety and engagement wh...

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$105K - $150K *

Transform construction project management by leveraging Autodesk solutions. Collaborate with clients to optimize workflows, deliver training, and ensure successful technology adoption, enhancing effic...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$104K - $188K *

Join a dynamic team to prepare and label medications, ensuring accuracy and compliance while supervising pharmacy technicians and students in a fast-paced environment focused on patient care and safet...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$105K - $150K *

Advance your career by leveraging your construction expertise to implement Autodesk solutions. Collaborate with clients to optimize project workflows, deliver training, and ensure successful technolog...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$105K - $150K *

Join a team that's transforming construction project management through technology. Leverage your industry expertise to guide customers in adopting Autodesk solutions, enhancing workflows, and driving...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Join a dynamic team to architect and implement cutting-edge MLOps strategies, leveraging Google Cloud's AI/ML stack. Drive innovation in model lifecycle management and collaborate with cross-functiona...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $115K *

Lead the charge in enhancing customer support by guiding a skilled team of Support Engineers. Balance hands-on technical assistance with operational oversight to ensure a world-class experience for cl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.