Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $95K *

Develop reliable applications by collaborating with IT leadership and users. Oversee projects from requirements gathering to deployment, ensuring software meets business needs while utilizing AI tools...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Unlock potential by transforming business needs into reliable applications. Collaborate with IT leadership to develop, test, and support innovative solutions, ensuring software effectively addresses p...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$90K - $113K *

Lead strategic initiatives to enhance advocacy for California's children and youth. Collaborate with stakeholders, manage programs, and drive fundraising efforts to ensure impactful policy changes and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Drive end-to-end payroll processes across multiple entities, ensuring accuracy and compliance. Manage domestic and international payroll, tax setups, and employee inquiries while building scalable sys...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Shape the future of finance operations by leading Oracle ERP enhancements, collaborating with cross-functional teams, and driving global standardization to optimize processes and support business grow...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$112K - $338K *

Join a team that's transforming state and local government through innovative Cloud ERP solutions. Lead complex engagements, drive functional design, and enhance operational efficiency while navigatin...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$81K - $136K *

Join a team that's pioneering innovative radar and surveillance solutions. Lead proposal management and program execution, ensuring high-quality submissions while collaborating across functions to dri...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in managing a technical team focused on Gitaly, driving performance, scalability, and maintainability while fostering a culture of accountability and ownership across distributed teams...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$131K - $197K *

Unlock strategic leadership in Workforce Management, optimizing resource planning across various channels to enhance service delivery and drive performance guarantees in a dynamic contact center envir...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$148K - $313K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them in architecting AI-first solutions within the Life Sciences sector, while driving internal initiatives and enhanc...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's redefining application security by guiding customers through complex evaluations. Leverage your expertise in offensive security to build relationships, deliver impactful demos, and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive growth by building and expanding enterprise pipelines through strategic outbound efforts and executive networking. Collaborate cross-functionally to secure high-value deals and establish long-te...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$143K - $153K *

Empower business transformation by translating capabilities into architectural solutions. Guide design strategies and integration mechanisms while advancing information management and governance acros...

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Unlock potential by architecting innovative IT solutions that align with client goals. Collaborate with sales teams and engage directly with customers to deliver tailored strategies, ensuring successf...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$93K - $110K *

Shape the future of restaurant construction by leading diverse projects, ensuring client satisfaction through effective management, coordination, and communication with teams and stakeholders across v...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$88K - $105K *

Discover a pivotal role in enhancing manufacturing operations through innovative SCADA, MES, and control systems solutions, driving efficiency and safety in a collaborative environment dedicated to co...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$73K - $132K *

Join a dynamic team as a Senior Environmental Chemist, providing expert oversight in environmental data management and validation. Lead projects ensuring compliance and quality in remediation efforts...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Technical Services

$144K - $230K *

Engage with our sales team as a Technical Sales Lead, driving technology evaluations and managing customer relationships. Leverage your expertise in telecommunications to ensure satisfaction throughou...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$135K - $280K *

Lead the charge in strategic construction project management, overseeing complex federal and private infrastructure projects. Drive operational excellence, team development, and client relationships w...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $159K *

Empower the Clinical Documentation Integrity team by ensuring staff competency through quality assurance, training, and performance management. Collaborate on action plans and foster associate develop...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$152K - $283K *

Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$123K - $168K *

Engage with healthcare professionals to drive product growth and acceptance. Build lasting relationships, educate stakeholders, and collaborate cross-functionally to enhance market presence and uphold...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $258K *

Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$105K - $120K *

Drive the substantiation of health claims for dietary supplements by reviewing scientific evidence and collaborating with cross-functional teams to ensure compliance with regulatory standards and enha...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.