Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$130K - $155K *

Drive the technical strategy for identity governance services, leading a team to enhance identity security across the organization. Collaborate with cross-functional teams to implement SailPoint solut...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Join us to lead the delivery of network infrastructure, overseeing contractors and ensuring high-quality installations. You'll manage site execution, coordinate with teams, and drive project success t...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $150K *

Innovate within a cutting-edge DataOps environment, ensuring the reliability and scalability of a Databricks-native data platform on Azure. Leverage AI for observability and pipeline management while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Engage with key strategic customers to foster relationships and drive growth. Collaborate across teams to deliver tailored solutions, ensuring customer satisfaction and long-term partnerships while ac...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $141K *

Lead the product direction for membership operations, balancing customer needs and enterprise requirements. Collaborate with teams to enhance workflows, improve operational outcomes, and ensure a seam...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$97K - $130K *

Optimize business processes and technology solutions by collaborating with stakeholders to gather requirements, drive implementation, and enhance user experience, ensuring alignment with organizationa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$90K - $135K *

Champion a culture of safety by leading initiatives, providing expert guidance, and ensuring compliance with safety standards across multiple projects. Collaborate with management to foster a safe wor...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Analyze and oversee corrosion inspections and repairs, ensuring compliance with regulations. Maintain records, perform system installations, and provide technical support while driving mitigation acti...

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$136K - $160K *

Drive transformation by partnering with architecture and engineering firms to enhance workflows through AI-enabled solutions. Collaborate with stakeholders to redefine processes, ensuring operational...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Lead the charge in medical oversight for clinical trials, ensuring high standards and executing timelines. Collaborate with cross-functional teams to enhance trial protocols and contribute to impactfu...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$250K - $300K *

Elevate inpatient cardiac care by joining a dedicated team focused on consultative cardiology. Enjoy a supportive environment with limited weekend call, advanced diagnostics, and a collaborative appro...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$107K - $188K *

Lead the charge in optimizing data center operations while managing a skilled team focused on installing and delivering essential network infrastructure. Drive compliance and enhance performance throu...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$140K - $150K *

Partner with us to deliver compassionate, whole-person care for patients with substance use disorders through our innovative telehealth platform, ensuring effective treatment and support in a fully re...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$127K - $159K *

Lead a dynamic Data Engineering team to develop innovative data solutions, supporting essential healthcare operations. Drive operational effectiveness, compliance, and collaboration while enhancing da...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$96K - $210K *

Lead personalized financial planning for senior executives, integrating workplace benefits into comprehensive strategies. Drive client engagement and satisfaction while managing relationships and expa...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$71K - $109K *

Engage with enterprise customers as a Senior Technical Support Specialist, providing expert guidance on complex compliance workflows and integrations. Drive resolution of critical issues while ensurin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Elevate your career by leading operational excellence across multiple retail and pharmacy locations. Drive team performance, enhance customer experiences, and implement strategic initiatives to foster...

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$151K - $178K *

Shape the future of compliance and trust in software security. Lead external examinations, manage customer diligence, and oversee third-party risk operations while mentoring a growing team dedicated t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Accelerate progress at the forefront of clinical research by ensuring effective oversight and management of clinical studies. Collaborate with teams to uphold quality standards and drive successful st...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Staffing

$87K - $157K *

Shape the future of utility substations by leading physical design efforts, optimizing layouts, and collaborating across disciplines to deliver innovative engineering solutions for EPC projects...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$150K - $180K *

Advance offensive security research by designing red team agents and automating tradecraft. Shape full-chain operations across diverse environments, ensuring robust detection-evasion capabilities and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$175K - $210K *

Lead and grow a high-performing sales team, driving enterprise revenue and strategy in a dynamic market. Collaborate with partners and stakeholders to expand business while shaping product direction a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$47K - $125K *

Join a team that champions technology solutions by leading a skilled group of Tech engineers to enhance customer experience and drive growth in smart home security installations...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$150K - $200K *

Help us drive revenue growth by activating strategic partnerships and channel relationships. This senior role focuses on maximizing sales potential across core product lines, ensuring effective collab...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$113K - $148K *

Develop and execute a strategic external communications plan to enhance reputation and visibility across the Americas, leveraging media relationships and editorial expertise to position the organizati...

1 week ago

  •   8 - 10 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.