Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior Manager IGA Engineering (Sailpoint ISC)- Remote
$130K - $155K *
Drive the technical strategy for identity governance services, leading a team to enhance identity security across the organization. Collaborate with cross-functional teams to implement SailPoint solut...
1 week ago
$120K - $145K *
Join us to lead the delivery of network infrastructure, overseeing contractors and ensuring high-quality installations. You'll manage site execution, coordinate with teams, and drive project success t...
1 week ago
$120K - $150K *
Innovate within a cutting-edge DataOps environment, ensuring the reliability and scalability of a Databricks-native data platform on Azure. Leverage AI for observability and pipeline management while...
1 week ago
$95K - $115K *
Engage with key strategic customers to foster relationships and drive growth. Collaborate across teams to deliver tailored solutions, ensuring customer satisfaction and long-term partnerships while ac...
1 week ago
Product Manager, Ignite Member Operations
$125K - $141K *
Lead the product direction for membership operations, balancing customer needs and enterprise requirements. Collaborate with teams to enhance workflows, improve operational outcomes, and ensure a seam...
1 week ago
$97K - $130K *
Optimize business processes and technology solutions by collaborating with stakeholders to gather requirements, drive implementation, and enhance user experience, ensuring alignment with organizationa...
1 week ago
$90K - $135K *
Champion a culture of safety by leading initiatives, providing expert guidance, and ensuring compliance with safety standards across multiple projects. Collaborate with management to foster a safe wor...
1 week ago
$80K - $95K *
Analyze and oversee corrosion inspections and repairs, ensuring compliance with regulations. Maintain records, perform system installations, and provide technical support while driving mitigation acti...
1 week ago
Principal AI Transformation Consultant
$136K - $160K *
Drive transformation by partnering with architecture and engineering firms to enhance workflows through AI-enabled solutions. Collaborate with stakeholders to redefine processes, ensuring operational...
1 week ago
Clinical Study Physician - Oncology - FSP
$160K - $200K *
Lead the charge in medical oversight for clinical trials, ensuring high standards and executing timelines. Collaborate with cross-functional teams to enhance trial protocols and contribute to impactfu...
Reposted 1 week ago
Cardiology Hospitalist | Weekday Schedule + Minimal Call | St. Louis
$250K - $300K *
Elevate inpatient cardiac care by joining a dedicated team focused on consultative cardiology. Enjoy a supportive environment with limited weekend call, advanced diagnostics, and a collaborative appro...
1 week ago
Data Center Infrastructure Delivery Manager , DCC Communities
$107K - $188K *
Lead the charge in optimizing data center operations while managing a skilled team focused on installing and delivering essential network infrastructure. Drive compliance and enhance performance throu...
Reposted 1 week ago
Nurse Practitioner / Physician Assistant - California
$140K - $150K *
Partner with us to deliver compassionate, whole-person care for patients with substance use disorders through our innovative telehealth platform, ensuring effective treatment and support in a fully re...
1 week ago
Manager of Data Engineering & Delivery (Data Science Production Engineering)
$127K - $159K *
Lead a dynamic Data Engineering team to develop innovative data solutions, supporting essential healthcare operations. Drive operational effectiveness, compliance, and collaboration while enhancing da...
Reposted 1 week ago
Vice President, Executive Planning Consultant - Northern California
$96K - $210K *
Lead personalized financial planning for senior executives, integrating workplace benefits into comprehensive strategies. Drive client engagement and satisfaction while managing relationships and expa...
1 week ago
Senior Technical Support Specialist
$71K - $109K *
Engage with enterprise customers as a Senior Technical Support Specialist, providing expert guidance on complex compliance workflows and integrations. Drive resolution of critical issues while ensurin...
1 week ago
District Manager - Relocation Available
$80K - $95K *
Elevate your career by leading operational excellence across multiple retail and pharmacy locations. Drive team performance, enhance customer experiences, and implement strategic initiatives to foster...
1 week ago
Staff Security Analyst (Governance and Trust)
$151K - $178K *
Shape the future of compliance and trust in software security. Lead external examinations, manage customer diligence, and oversee third-party risk operations while mentoring a growing team dedicated t...
1 week ago
Clinical Oversight Manager (COM) - USA
$110K - $130K *
Accelerate progress at the forefront of clinical research by ensuring effective oversight and management of clinical studies. Collaborate with teams to uphold quality standards and drive successful st...
1 week ago
Senior EPC Physical Substation Engineer
$87K - $157K *
Shape the future of utility substations by leading physical design efforts, optimizing layouts, and collaborating across disciplines to deliver innovative engineering solutions for EPC projects...
1 week ago
$150K - $180K *
Advance offensive security research by designing red team agents and automating tradecraft. Shape full-chain operations across diverse environments, ensuring robust detection-evasion capabilities and...
1 week ago
Senior Director, Sales (Enterprise West)
$175K - $210K *
Lead and grow a high-performing sales team, driving enterprise revenue and strategy in a dynamic market. Collaborate with partners and stakeholders to expand business while shaping product direction a...
1 week ago
Smart Home Consultant Team Manager
$47K - $125K *
Join a team that champions technology solutions by leading a skilled group of Tech engineers to enhance customer experience and drive growth in smart home security installations...
Reposted 1 week ago
Senior Director, Partner Sales Activation - remote opportunity
$150K - $200K *
Help us drive revenue growth by activating strategic partnerships and channel relationships. This senior role focuses on maximizing sales potential across core product lines, ensuring effective collab...
1 week ago
Director, External Communications
$113K - $148K *
Develop and execute a strategic external communications plan to enhance reputation and visibility across the Americas, leveraging media relationships and editorial expertise to position the organizati...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.