Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $98K *

Shape the future of Payment solutions by driving client acquisition and retention. You'll consult on Treasury Management, optimize business cash flow, and collaborate with professionals to exceed sale...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $90K *

Join a team that's dedicated to enhancing customer success by managing relationships, driving revenue growth, and ensuring exceptional service for K-12 education clients. Collaborate across department...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$145K - $155K *

Transform your career by joining a dynamic team as a VDI Engineer, where you'll design, configure, and maintain a global virtual desktop environment while providing expert troubleshooting and support...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Unlock your potential by developing integrated strategies that enhance consumer experiences across pharmacy solutions and client initiatives. Collaborate with diverse teams to drive alignment and deli...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $166K *

Optimize site contract management by reviewing, drafting, and negotiating various legal agreements. Collaborate with clinical teams to ensure timely deliverables and serve as a subject matter expert i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Champion comprehensive psychiatric care for seniors by collaborating with multidisciplinary teams to deliver personalized mental health services across various living facilities, ensuring continuity a...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $130K *

Shape the future of our global environmental monitoring products by leading product marketing, influencing sales strategies, and enhancing competitive positioning. Collaborate across teams to create i...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$170K - $250K *

Unlock potential by owning a product area end-to-end, collaborating with engineering and customers to drive innovation and deliver impactful solutions in a dynamic market...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$63K - $177K *

Transform client operations by providing data-driven insights and coaching. Collaborate with teams to prioritize improvement opportunities and ensure sustainable change through effective leadership an...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$70K - $196K *

Drive innovative cloud solutions by designing reusable architectures and collaborating with clients. Leverage AWS expertise to enhance delivery, support migrations, and stay ahead of emerging technolo...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Partner with us to optimize business processes and drive application development. As a Business Analyst, you'll engage with IT and stakeholders to translate requirements into actionable work items, en...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $114K *

Lead critical application remediation efforts, engaging stakeholders to assess vulnerabilities and document remediation strategies, ensuring sustainable currency capabilities and effective governance...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$76K - $95K *

Advance the intake process by managing conflicts analysis, ensuring timely responses, and supporting new client matters. Collaborate with attorneys and staff to uphold high service standards across mu...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$95K - $115K *

Analyze financial performance and operational metrics to support strategic growth initiatives. Collaborate with cross-functional teams to enhance reporting accuracy and drive insights for decision-mak...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to creating impactful medical education content for healthcare providers and patients. Collaborate closely with scientific and account teams to deliver high-quality materi...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Join a team that's transforming home and specialty insurance solutions through data-driven analysis and innovative project management, delivering value to customers and driving growth in a dynamic env...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$300K - $357K *

Join a team that's redefining business strategy in the Resources industry. Leverage your expertise to guide clients through complex challenges, driving impactful decisions at the C-suite level while m...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$73K - $102K *

Drive end-to-end Oracle EBS R12 upgrades, ensuring seamless technical design, configuration, and deployment. Collaborate with teams to resolve issues, develop customizations, and enhance system integr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $154K *

Shape the future of fleet management by overseeing vehicle lifecycle, ensuring compliance, and enhancing operational efficiency. Collaborate with drivers and stakeholders to streamline onboarding, mai...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $120K *

Empower growth by managing and expanding relationships in North American Industrial, Academic, Pharmaceutical, and Biotech markets through proactive sales strategies and digital engagement...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive integrated behavioral health solutions by providing expert psychological care to veterans in home settings. Collaborate with healthcare teams to enhance patient outcomes through evidence-based p...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$173K - $255K *

Join a dynamic team to enhance product security throughout the development lifecycle. Collaborate with engineering and product teams to identify vulnerabilities, automate processes, and implement secu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Transform the future of data center construction by leading mechanical field delivery. Oversee contractors and ensure safe installation of cooling infrastructure, while coordinating with multiple team...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Take ownership of client relationships and campaign performance, managing a portfolio of accounts. Lead strategy discussions, optimize Meta campaigns, and ensure client satisfaction through proactive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$118K - $222K *

Empower the delivery of transformative technology initiatives by collaborating with leaders to enhance project execution, manage dependencies, and drive value across teams, ensuring successful outcome...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.