Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$117K - $158K *
Manage and prioritize the ERP product backlog, translating business needs into actionable requirements. Collaborate with stakeholders to enhance operational effectiveness and drive continuous improvem...
1 week ago
$140K - $170K *
Shape the future of healthcare market strategies by analyzing trends, defining growth initiatives, and collaborating cross-functionally to drive innovation in life science and medical services. Lead m...
1 week ago
Senior Project Manager - Mechanical Engineering
$115K - $135K *
Lead mechanical engineering projects from scope to design, ensuring optimal performance and compliance with University standards. Collaborate with architects and engineers, shaping the future of campu...
1 week ago
Director, Deployment Strategy and Integration
$170K - $220K *
Drive your career forward by leading cross-functional deployment strategies. This senior role requires exceptional judgment and communication skills to navigate complex, ambiguous situations and deliv...
1 week ago
Senior Data Scientist - Consumer
$190K - $267K *
Lead data-driven strategies to enhance product development and user growth. Collaborate across teams to implement sophisticated analyses and metrics that drive business decisions and mentor junior tea...
Reposted 1 week ago
$110K - $130K *
Lead innovative digital solutions by architecting and developing D365 and Power Platform applications. Collaborate with clients to enhance their systems while mentoring a team of developers to ensure...
1 week ago
$80K - $95K *
Join a team that's shaping the future of mission-critical systems. Leverage your expertise in UPS, battery, switchgear, and generator systems while coordinating detailed designs and ensuring complianc...
1 week ago
Senior Product Marketing Manager - Core Products
$153K - $220K *
Shape the market presence of our innovative cybersecurity solutions through strategic messaging, product launches, and sales enablement. Collaborate with teams to drive demand and elevate the buyer's...
Reposted 1 week ago
Cloud Application & AI Security Engineer
$93K - $140K *
Elevate cloud security by enhancing standards and implementing risk-based controls across Azure and AWS. Collaborate with teams to secure applications and support AI initiatives, ensuring robust gover...
1 week ago
Senior Cybersecurity Engineer - Security Service Edge
$97K - $161K *
Drive the design and implementation of security systems, enhancing existing solutions while solving complex challenges. Collaborate with cross-functional teams to ensure robust cybersecurity measures...
1 week ago
$100K - $125K *
Join a team that's dedicated to delivering expert tax solutions while ensuring compliance and fostering client relationships. Leverage your extensive experience in tax preparation and planning to driv...
1 week ago
$80K - $95K *
Grow your career with a dynamic role overseeing injection mold tooling development, collaborating across teams to ensure timely production of high-quality automotive parts while managing multiple proj...
1 week ago
$180K - $210K *
Accelerate progress at the forefront of AI integration, designing secure enterprise architectures that enhance healthcare services for Veterans. Lead initiatives across cloud and on-premise platforms...
1 week ago
Principal Technical Program Manager, Data Centers
$102K - $209K *
Empower your career by leading end-to-end data center programs, ensuring seamless delivery from site selection to operational handover. Collaborate with diverse teams and manage complex projects to dr...
1 week ago
Staff Scientist, Bioinformatics/RWD
$158K - $197K *
Transform real-world health data into actionable insights by leveraging advanced bioinformatics and AI techniques. Lead innovative analyses in oncology and genomics, facilitating cross-functional coll...
Reposted 1 week ago
Senior Copywriter, Promotional Medical Writing
$80K - $100K *
Shape the future of medical communications by crafting high-quality, scientifically accurate content. Collaborate with diverse teams to deliver impactful resources that meet client needs while mentori...
1 week ago
$124K - $207K *
Transform global benefits strategies by leading a dynamic team, ensuring compliance, and enhancing employee wellbeing. Drive innovative solutions while managing vendor relationships and collaborating...
1 week ago
Director, Audience Intelligence Products| US: Remote
$150K - $159K *
Lead the charge in transforming audience intelligence through innovative product strategies, enhancing consumer insights and data-driven solutions for brands and partners while ensuring privacy and co...
1 week ago
Sr. Product Manager, Product Operations & Insights| US: Remote
$150K - $159K *
Drive product health standards by defining metrics and telemetry for all products. Collaborate with cross-functional teams to ensure consistent data definitions and empower teams with self-serve dashb...
1 week ago
$100K - $120K *
Advance payer integrations by managing complex processes and relationships. Drive outreach and research to establish direct connectivity with 3,000+ payers, ensuring accurate data and efficient handof...
1 week ago
Manager, Network Management (National Health Systems)
$54K - $159K *
Champion contract negotiations by driving initiatives, cultivating relationships, and ensuring compliance with performance goals. Leverage expertise to support cost-saving strategies and enhance cross...
Reposted 1 week ago
$120K - $160K *
Manage labor and employment legal matters, ensuring compliance and providing strategic counsel. Collaborate with HR and stakeholders to develop solutions, supervise outside counsel, and educate on pol...
1 week ago
$120K - $145K *
Drive mobile engineering excellence by leading app development, mentoring engineers, and integrating AI solutions to enhance user experiences across iOS and Android platforms while collaborating with...
1 week ago
$85K - $100K *
Unlock your potential by providing essential physical therapy services in home settings. Collaborate with a dedicated team to enhance patient mobility and health, ensuring quality care and support for...
1 week ago
$85K - $100K *
Unlock potential by providing exceptional physical therapy services in home settings, enhancing patient mobility and health. Collaborate with a supportive team to deliver quality care and ensure compl...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.