Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$135K - $160K *

Drive your career forward by developing cutting-edge control planes for AI infrastructure. Collaborate with a dynamic team to enhance cloud-native orchestration platforms, leveraging your expertise in...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Champion the development of a customer-focused software product, leading engineering teams and driving product strategy to enhance RLMS. Oversee technology investments, infrastructure, and security to...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$130K - $165K *

Elevate public sector solutions by designing and delivering scalable Salesforce applications. Collaborate with cross-functional teams to enhance operational efficiency and modernize processes, ensurin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a dynamic team to manage tax compliance and planning across multiple entities. Collaborate with Finance, Legal, and Operations to enhance tax processes and support strategic projects in a growing...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$71K - $106K *

Engage in direct patient care by assessing, planning, and implementing nursing strategies while collaborating with a multidisciplinary team to enhance patient satisfaction and outcomes...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $175K *

Optimize strategies by leading multi-channel collections initiatives, leveraging analytics and AI to enhance performance and drive payment conversions. Collaborate cross-functionally to design and imp...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Transform the future of digital engagement by leading Adobe Target implementations. Collaborate across teams to develop personalized strategies that enhance user experiences and drive measurable busin...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Transform data integration in modern data centers by leading a team to design and implement edge collectors, ensuring seamless connectivity and efficient onboarding across multiple sites while collabo...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$195K - $230K *

Join a team that's redefining partnership development in the fintech space. You'll drive new opportunities with PSPs and banks, managing complex deals and collaborating cross-functionally to enhance C...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$216K - $361K *

Elevate your career by driving sales growth in enterprise software across retail, energy management, and telecommunications. Collaborate with top clients to achieve strategic goals and expand market p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$210K - $250K *

Transform patient care by leading a comprehensive cardiology program, managing clinical, administrative, and research components while ensuring high-quality treatment for cardiac diseases in a collabo...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$148K - $201K *

Join us to shape the future of secure software delivery by developing AI-driven workflows and orchestrating complex systems. Collaborate with cross-functional teams to create intuitive solutions that...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$91K - $122K *

Empower and lead a high-performing sales team to exceed targets, fostering strategic relationships and guiding consultative sales strategies that highlight key market differentiators for sustained gro...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$120K - $185K *

Transform the future of engineering design by leading diverse teams to deliver high-quality electrical engineering solutions. Drive project success through strategic oversight, mentoring, and adherenc...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$135K - $145K *

Drive innovative software solutions by developing robust, cloud-native systems that enhance provider data management capabilities and meet the evolving needs of clients in a dynamic, collaborative env...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $140K *

Unlock potential by joining a dynamic team that enhances naval supply systems through application engineering, integration, and support. Collaborate with partners to refine requirements and ensure sys...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Join us to lead strategic projects in speech and audio, driving high-quality data programs for AI. You'll manage complex workflows, enhance client communication, and ensure quality standards in a rapi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$204K - $290K *

Manage the Resilience Engineering team to enhance system reliability through production load testing and chaos engineering while fostering a proactive safety culture across engineering practices...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Join a team that's redefining operational excellence in healthcare. This role drives performance and compliance across call center operations, enhancing efficiency and quality through strategic planni...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $121K *

Shape your career by leading a dynamic team in Operations, ensuring client satisfaction and effective implementation of Web Pay Products. Drive success through coaching and problem-solving in a fully...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$160K - $390K *

Join a team that's dedicated to delivering high-quality dental care while enhancing your skills through mentorship and advanced technology in a collaborative environment focused on patient outcomes...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join us in providing exceptional nursing leadership and care management! You will oversee nursing services, ensuring quality standards, and lead nursing staff while managing center operations in the a...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Join a team that's dedicated to enhancing client relationships and driving success. Oversee client performance, mentor staff, and ensure compliance while collaborating with various departments to deli...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $214K *

Innovate and lead strategic partnerships in the HCM and WFM sectors, driving joint solutions and aligning cross-functional teams to enhance product offerings and deliver exceptional value to customers...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$100K - $120K *

Unlock potential by leading project coordination and trade management for advanced technology initiatives, ensuring quality and efficiency across diverse construction environments while supporting ope...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.