Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$150K - $159K *

Drive the transformation of AI agent capabilities into scalable, revenue-generating products. Collaborate across teams to define strategies, evaluate opportunities, and lead product commercialization...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $143K *

Optimize your career by developing and executing clinical marketing strategies that enhance customer engagement and drive adoption of innovative patient monitoring solutions. Collaborate with cross-fu...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Transform your career by leveraging your AWS expertise in a dynamic DevOps role. Collaborate with a hands-on team to enhance infrastructure and streamline development processes while tackling complex...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$68K - $103K *

Join a team that's enhancing clinical research by drafting and negotiating diverse agreements, ensuring compliance with timelines, and collaborating with global stakeholders to achieve successful proj...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Optimize the promotional review process by coordinating cross-functional workflows, ensuring compliance, and facilitating timely approvals of marketing materials. Collaborate with internal and externa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Transform quality management systems and compliance programs to enhance supplier performance and regulatory adherence. Collaborate cross-functionally to drive operational efficiencies and ensure produ...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$89K - $127K *

Transform your career by owning strategic lifecycle marketing initiatives that drive revenue growth. Collaborate cross-functionally to optimize customer journeys and enhance user experiences through d...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$207K - $267K *

Unlock potential by leading global procurement strategies, optimizing vendor management, and driving efficiency across technology and software categories while mentoring a high-performing team...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Media

$129K - $172K *

Transform critical customer service challenges into strategic solutions by leading a high-performing team focused on executive escalations, automation, and continuous improvement initiatives that enha...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$95K - $115K *

Pioneer impactful marketing solutions by mastering platform administration, driving key integrations, and enabling agile collaboration with cross-functional teams to enhance engagement strategies and...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Lead the charge in customer success by ensuring seamless integration and support for connected hardware, driving account growth through exceptional service and technical expertise...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Transform the insurance appeals process by managing, researching, and drafting compliant responses to billing deductions. Collaborate with legal teams to enhance efficiency and build strong relationsh...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$96K *

Take ownership of e-commerce platform administration and vendor operations, ensuring seamless integration and performance of SaaS tools. Collaborate cross-functionally to enhance direct-to-consumer ca...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$122K - $317K *

Partner with us to architect transformative operational models, guiding organizations through change with insights and strategies that foster agility, while mentoring teams to innovate and excel in th...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$110K - $140K *

Shape the future of healthcare integration by leading and executing complex HL7 projects. Utilize your expertise in medical informatics and enhancing customer satisfaction while managing dynamic, mult...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Join a team that's driving growth in modular sales by managing complex rental and sales opportunities. Leverage your consultative sales skills to build strategic relationships and achieve revenue goal...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Lead the charge in optimizing nursing operations across multiple facilities, ensuring high standards of care and inspiring teams to excel in a dynamic, multi-site environment. Drive clinical excellenc...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$150K - $200K *

Elevate your career by leading HCP engagement and clinical marketing initiatives. Drive strategic insights and educational content for the HSCT portfolio, fostering impactful connections and enhancing...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive client success by managing a portfolio of accounts, optimizing Meta campaigns, and fostering strong relationships. Lead strategy discussions, analyze performance data, and ensure client satisfac...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Unlock your potential by managing client relationships and Meta campaigns. Drive performance, optimize strategies, and ensure client satisfaction while leading multiple accounts in a dynamic, hands-on...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Transform enterprise data architecture through expert Azure platform engineering, enhancing reliability, governance, and cost-efficiency while collaborating with cross-functional teams to optimize dat...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$140K - $160K *

Champion the future of commercial sales by leading strategy, driving growth, and fostering key customer relationships. Collaborate cross-functionally to achieve sales targets and enhance market share...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$132K - $178K *

Optimize supplier quality oversight by leading cross-functional teams, ensuring compliance with global standards, and driving continuous improvement initiatives to enhance performance and mitigate ris...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$88K - $118K *

Join us to analyze and document business and technical requirements, implement process improvements, and support ERP projects. Collaborate with teams to ensure accurate reporting and optimize system s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$150K - $180K *

Lead the future of patient experience by driving strategic initiatives and operational excellence in a high-volume healthcare contact center. Collaborate with cross-functional teams to enhance service...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.