Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$153K - $220K *

Transform demand generation strategies into actionable plans that drive revenue growth. Collaborate with marketing leaders to optimize the lead lifecycle and enhance funnel performance, ensuring align...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$185K - $235K *

Transform engineering practices by leading AI Enablement initiatives, enhancing workflows, and driving adoption of AI standards across teams. Collaborate with stakeholders to measure progress and deli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$204K - $276K *

Empower healthcare innovation by leading strategic partnerships and account management to enhance access and drive growth for Alnylam products, ensuring mutual value creation for healthcare systems an...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$255K - $383K *

Transform enterprise relationships by leading strategic sales initiatives, managing complex cycles, and nurturing partnerships to drive significant revenue growth in a high-impact territory...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Transform patient outcomes by delivering expert neuropsychological assessments for outpatients recovering from neurological conditions. Collaborate with a dedicated interdisciplinary team to enhance r...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $88K *

Lead the charge in managing home health patient care, coordinating with therapy teams, and developing personalized care plans while enjoying a flexible schedule and competitive pay structure...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $110K *

Transform financial operations by providing analytical support, enhancing reporting processes, and collaborating with cross-functional teams to drive profitability and efficiency in budgeting and fore...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Accelerate progress at customer success by managing a diverse portfolio, ensuring product adoption, and driving retention through proactive engagement and collaboration with cross-functional teams...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $155K *

Unlock potential by rapidly transforming customer insights into innovative prototypes. Collaborate with a dynamic team to build scalable products from scratch, leveraging AI tools and existing platfor...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $150K *

Lead the successful delivery of complex automation projects, ensuring alignment with specifications and timelines. Collaborate with cross-functional teams to manage risks and maintain quality standard...

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$190K - $300K *

Join a team that's driving transformation by building executive relationships and orchestrating high-impact solutions. This role focuses on client growth strategy, transaction advisory, and delivering...

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$284K - $385K *

Shape the future of technology by tackling complex challenges and driving AI adoption. Collaborate across teams to define long-term strategies, enhance customer experiences, and influence product dire...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Consumer Technology

$190K - $300K *

Accelerate growth by building executive relationships and orchestrating high-impact solutions. Lead client strategies, drive business origination, and shape transformative advisory offerings to delive...

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$150K - $180K *

Shape the future of sales operations by leading logistics, customer onboarding, and revenue reporting for a dynamic B2B technology company. Drive strategic initiatives and ensure seamless processes th...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$210K - $253K *

Lead strategic partnerships to drive growth and success in a dynamic healthcare ecosystem. Collaborate with internal teams and external stakeholders to enhance relationships, execute activation plans...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Elevate the future of travel by leading AI-driven hotel booking innovations. Collaborate closely with the CEO to shape product direction, enhance existing platforms, and build a dynamic team focused o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K *

Join a dynamic team to oversee complex enterprise implementations, ensuring successful delivery across multiple departments. Leverage AI tools and project management expertise to enhance stakeholder e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$70K - $205K *

Shape the future of MedTech by empowering global teams to excel in project delivery, leveraging AI, and transforming supply chain strategies while building exceptional client relationships and guiding...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$163K - $413K *

Lead strategic initiatives to drive growth in Google Cloud Security partnerships, managing high-stakes sales and executive relationships globally. Collaborate with cross-functional teams to optimize o...

1 week ago

  •   11 - 15 years exp.  •   Business Services

$84K - $126K *

Lead the charge in ensuring product quality and safety across the supply chain. Collaborate with partners, conduct audits, and implement quality control measures to drive operational excellence and co...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$98K - $172K *

Lead the charge in delivering exceptional pharmaceutical care, ensuring compliance and fostering community engagement while empowering patients through education and support in a dynamic pharmacy envi...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$206K - $257K *

Lead and mentor a dynamic team of Enterprise Solution Engineers, driving AI-enabled strategies and customer success across the US South. Collaborate with cross-functional teams to enhance product valu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $214K *

Shape the future of data center projects by leading preconstruction efforts, ensuring optimal financial positioning, and fostering strong team collaboration to deliver exceptional results and client s...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Lead the charge in expanding and retaining enterprise client relationships, driving revenue growth and strategic account management across regions. Develop and mentor a high-performing account team to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate customer success by guiding clients through onboarding and product adoption. Serve as a trusted advisor, ensuring maximum value from solutions while advocating for customer needs within the or...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.