Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$138K - $165K *

Champion the future of quantum computing by defining product vision and driving development for innovative solutions. Collaborate with cross-functional teams to integrate quantum capabilities into SAS...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$84K - $129K *

Drive innovative structural engineering solutions for nuclear facilities, collaborating with multidisciplinary teams to enhance safety and efficiency. Guide junior engineers while leveraging advanced...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$77K - $118K *

Elevate your career by designing high voltage substations, collaborating with engineers to create detailed drawings and plans. Utilize your expertise in AutoCAD or MicroStation to deliver high-quality...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$85K - $130K *

Drive the design and modification of power plant electrical systems, collaborating with multi-disciplined teams to create detailed diagrams and wiring drawings. Engage in field data gathering and ensu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$114K - $200K *

Champion growth by leading the Enterprise Sales team, driving member acquisition, and executing strategic sales initiatives in the cybersecurity sector. Collaborate with stakeholders to enhance sales...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $160K *

Transform project scheduling by leading high-visibility initiatives, ensuring compliance with CPM best practices, and mentoring teams to exceed client expectations while managing complex resource allo...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$100K - $145K *

Elevate organizational performance by facilitating hands-on training for construction teams, enhancing skills in safety, quality, and standard processes while championing corporate culture and continu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$162K - $195K *

Shape the future of cardiovascular care by driving the launch of a novel cardiac myosin inhibitor. Collaborate with healthcare professionals and internal teams to establish strategic relationships and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$162K - $195K *

Drive sales performance by launching a novel cardiac myosin inhibitor, building strategic relationships with healthcare providers, and delivering impactful solutions to meet patient needs in your terr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$162K - $195K *

Lead the launch of a novel cardiac myosin inhibitor in your territory, driving sales and building strategic relationships with healthcare providers. Collaborate with internal teams to meet patient nee...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform patient care by providing expert neuropsychological assessments and interventions. Collaborate with interdisciplinary teams to enhance rehabilitation outcomes for individuals recovering from...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Transform lives as a Clinical Neuropsychologist, providing essential assessments and interventions for patients recovering from neurological conditions. Collaborate with interdisciplinary teams to enh...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$121K - $156K *

Join a team that's shaping urban transportation infrastructure by leading innovative rail and transit projects. Collaborate across disciplines to deliver high-quality designs and manage client relatio...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$90K - $105K *

Drive the migration of patient data within a healthcare IT modernization program. Oversee planning, execution, and reporting for your workstream, ensuring alignment with stakeholders and delivery of h...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$160K - $210K *

Lead the charge in transforming Cyber Governance, Risk & Compliance through innovative data, AI, and automation strategies. Drive measurable outcomes and modernize technology platforms while building...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $110K *

Optimize patient care by leading the rehabilitation department, ensuring compliance and financial performance while fostering teamwork and excellence in service delivery across multiple sites...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Optimize partner relationships by managing implementations and operations for new agreements. Drive success through effective communication, performance monitoring, and strategic growth initiatives, e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $150K *

Join a team that's redefining business intelligence through Power BI. You'll develop impactful reports and dashboards, enhance client-facing platforms, and ensure data integrity while collaborating wi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$154K - $216K *

Champion community engagement by designing and executing lifecycle programs that educate and empower moderators through strategic, multichannel campaigns, ensuring seamless communication and community...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Media

$100K - $115K *

Optimize revenue accounting and billing operations for a rapidly growing SaaS organization. Collaborate with leadership on process improvements, ASC 606 compliance, and support integration initiatives...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Elevate your career by leading innovative QC projects, collaborating with teams, conducting advanced analytical testing, and ensuring compliance while training fellow scientists in a supportive, fast...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Champion innovative Salesforce Field Service solutions, leading implementations and integrations while mentoring teams and advising clients on optimization and transformation strategies for enhanced o...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Empower creativity by transforming ambitious concepts into innovative digital experiences. Collaborate with designers and engineers to prototype and build interactive projects, leveraging your technic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Champion new business growth by leveraging your consultative sales expertise to build relationships with utility and public sector clients, driving revenue and delivering tailored solutions that meet...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $95K *

Bring your expertise to our team as you design and optimize 3-phase power transformers, ensuring exceptional performance and quality through technical innovation and collaboration with cross-functiona...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.