Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior Product Manager, Quantum
$138K - $165K *
Champion the future of quantum computing by defining product vision and driving development for innovative solutions. Collaborate with cross-functional teams to integrate quantum capabilities into SAS...
1 week ago
Senior Special Structural Analysis Engineer 2 - Nuclear
$84K - $129K *
Drive innovative structural engineering solutions for nuclear facilities, collaborating with multidisciplinary teams to enhance safety and efficiency. Guide junior engineers while leveraging advanced...
1 week ago
Senior Substation Physical Designer 1 -- Grid
$77K - $118K *
Elevate your career by designing high voltage substations, collaborating with engineers to create detailed drawings and plans. Utilize your expertise in AutoCAD or MicroStation to deliver high-quality...
1 week ago
Senior Electrical Designer 2 - Nuclear Power
$85K - $130K *
Drive the design and modification of power plant electrical systems, collaborating with multi-disciplined teams to create detailed diagrams and wiring drawings. Engage in field data gathering and ensu...
1 week ago
Director of Enterprise Sales - Remote
$114K - $200K *
Champion growth by leading the Enterprise Sales team, driving member acquisition, and executing strategic sales initiatives in the cybersecurity sector. Collaborate with stakeholders to enhance sales...
1 week ago
$110K - $160K *
Transform project scheduling by leading high-visibility initiatives, ensuring compliance with CPM best practices, and mentoring teams to exceed client expectations while managing complex resource allo...
1 week ago
Lead Operations Technical Instructor
$100K - $145K *
Elevate organizational performance by facilitating hands-on training for construction teams, enhancing skills in safety, quality, and standard processes while championing corporate culture and continu...
1 week ago
Cardiovascular Account Specialist - U.S. Sales, Philadelphia East, PA
$162K - $195K *
Shape the future of cardiovascular care by driving the launch of a novel cardiac myosin inhibitor. Collaborate with healthcare professionals and internal teams to establish strategic relationships and...
1 week ago
Cardiovascular Account Specialist - U.S. Sales, Harrisburg, PA
$162K - $195K *
Drive sales performance by launching a novel cardiac myosin inhibitor, building strategic relationships with healthcare providers, and delivering impactful solutions to meet patient needs in your terr...
1 week ago
Cardiovascular Account Specialist - U.S. Sales, Des Moines, IA
$162K - $195K *
Lead the launch of a novel cardiac myosin inhibitor in your territory, driving sales and building strategic relationships with healthcare providers. Collaborate with internal teams to meet patient nee...
1 week ago
$100K - $120K *
Transform patient care by providing expert neuropsychological assessments and interventions. Collaborate with interdisciplinary teams to enhance rehabilitation outcomes for individuals recovering from...
1 week ago
$100K - $120K *
Transform lives as a Clinical Neuropsychologist, providing essential assessments and interventions for patients recovering from neurological conditions. Collaborate with interdisciplinary teams to enh...
1 week ago
$121K - $156K *
Join a team that's shaping urban transportation infrastructure by leading innovative rail and transit projects. Collaborate across disciplines to deliver high-quality designs and manage client relatio...
1 week ago
Healthcare IT Workstream Project Manager
$90K - $105K *
Drive the migration of patient data within a healthcare IT modernization program. Oversee planning, execution, and reporting for your workstream, ensuring alignment with stakeholders and delivery of h...
1 week ago
Director of Engineering, Cyber GRC Data, AI & Automation
$160K - $210K *
Lead the charge in transforming Cyber Governance, Risk & Compliance through innovative data, AI, and automation strategies. Drive measurable outcomes and modernize technology platforms while building...
1 week ago
$90K - $110K *
Optimize patient care by leading the rehabilitation department, ensuring compliance and financial performance while fostering teamwork and excellence in service delivery across multiple sites...
1 week ago
Partner Success Manager, Manufacturer & Specialty Partnerships
$95K - $115K *
Optimize partner relationships by managing implementations and operations for new agreements. Drive success through effective communication, performance monitoring, and strategic growth initiatives, e...
1 week ago
Senior Business Intelligence Analyst
$135K - $150K *
Join a team that's redefining business intelligence through Power BI. You'll develop impactful reports and dashboards, enhance client-facing platforms, and ensure data integrity while collaborating wi...
1 week ago
Senior Community Lifecycle Manager
$154K - $216K *
Champion community engagement by designing and executing lifecycle programs that educate and empower moderators through strategic, multichannel campaigns, ensuring seamless communication and community...
Reposted 1 week ago
Senior Revenue Accountant (Virtual/Remote)
$100K - $115K *
Optimize revenue accounting and billing operations for a rapidly growing SaaS organization. Collaborate with leadership on process improvements, ASC 606 compliance, and support integration initiatives...
Reposted 1 week ago
$95K - $115K *
Elevate your career by leading innovative QC projects, collaborating with teams, conducting advanced analytical testing, and ensuring compliance while training fellow scientists in a supportive, fast...
Reposted 1 week ago
Salesforce Technical Architect
$135K - $160K *
Champion innovative Salesforce Field Service solutions, leading implementations and integrations while mentoring teams and advising clients on optimization and transformation strategies for enhanced o...
1 week ago
$110K - $130K *
Empower creativity by transforming ambitious concepts into innovative digital experiences. Collaborate with designers and engineers to prototype and build interactive projects, leveraging your technic...
1 week ago
$100K - $120K *
Champion new business growth by leveraging your consultative sales expertise to build relationships with utility and public sector clients, driving revenue and delivering tailored solutions that meet...
1 week ago
$80K - $95K *
Bring your expertise to our team as you design and optimize 3-phase power transformers, ensuring exceptional performance and quality through technical innovation and collaboration with cross-functiona...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.