Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $150K *

Unlock potential by leading strategic initiatives for a portfolio of Department of War customers. Drive growth, foster executive relationships, and ensure impactful operational outcomes while guiding...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Transform initiatives through expert project management, elevating communication and cross-team coordination to ensure operational excellence and drive strategic goals...

Reposted today

  •   Less than 5 years exp.  •   Business Services

$90K - $120K *

Transform customer experiences by leading a dynamic Policy Operations team, driving process innovation, and collaborating with cross-functional partners to enhance service delivery and operational eff...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Drive impactful projects forward, align stakeholders, and enhance operational efficiency. Collaborate across teams to manage priorities and deliver precise communications in a fast-paced environment...

Reposted today

  •   Less than 5 years exp.  •   Business Services

$255K - $295K *

Lead the technical direction for foundational services, guiding architecture and execution across teams to enhance platform capabilities for customer and partner experiences. Mentor engineers and infl...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Explore new business opportunities and build lasting client relationships. Drive the full sales cycle, from prospecting to closing, while collaborating with cross-functional teams to deliver tailored...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Champion women's health by providing comprehensive prenatal and gynecologic care in a supportive, collaborative environment. Enjoy a four-day work week with no hospital responsibilities, fostering pro...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$73K - $115K *

Launch your engineering career by tackling real manufacturing challenges. Engage in a three-year rotational program that fosters growth through mentorship, diverse experiences, and exposure to industr...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$90K - $110K *

Lead the charge in resolving complex technical issues, enhancing support processes, and collaborating with engineering teams to improve product functionality and customer satisfaction in a dynamic B2B...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Unlock potential by leading clinical excellence in a supportive environment, leveraging advanced technology and a dedicated team to provide exceptional patient care while maintaining clinical autonomy...

Reposted today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$235K - $270K *

Unlock potential by leading actuarial strategy and health economic analyses. Collaborate with cross-functional teams to enhance value propositions and drive commercial growth while translating complex...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$200K - $225K *

Transform healthcare data into actionable insights by leading actuarial strategy and health economic analyses. Collaborate with cross-functional teams to enhance value propositions and drive commercia...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$162K - $203K *

Drive impactful market research initiatives by collaborating with cross-functional teams to translate business needs into actionable insights, ensuring high-quality execution and strategic decision-ma...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate product design by leading innovative initiatives, guiding cross-functional teams, and shaping user experiences from concept to delivery. Drive design excellence and foster a culture of feedbac...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead and scale a high-performing global SDR team, optimizing outbound strategies and driving pipeline through innovative coaching and performance tracking in a dynamic, fast-paced environment...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$117K - $165K *

Lead the charge in developing strategic medical content while collaborating cross-functionally and ensuring high standards of accuracy and clarity, influencing multiple therapeutic projects for a dive...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Manage vendor intake and performance oversight, ensuring compliance and alignment with enterprise objectives while fostering strong vendor relationships and leading a team to drive operational excelle...

Missouri, USRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Lead the infrastructure engineering team to drive strategic initiatives, enhance developer productivity, and ensure reliability as the organization scales towards ambitious growth targets, including A...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$180K - $225K *

Transform the future of auto claims by designing AI agents that enhance decision-making and streamline processes. Join a dynamic team to build innovative solutions that improve efficiency and accuracy...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$147K - $273K *

Drive financial strategy for a leading K12 assessment business, partnering with senior leadership to shape commercial decisions, manage risks, and enhance performance across diverse business models wh...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$77K - $104K *

Lead transformative knowledge strategies that enhance customer experiences and drive AI integration across multiple functions. Collaborate with teams to ensure knowledge is accurate, discoverable, and...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$120K - $140K *

Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Engage with cross-functional teams to drive AI security product marketing initiatives, focusing on buyer insights, competitive analysis, and effective sales enablement. Collaborate on launches and con...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$145K - $185K *

Join a dynamic team to drive innovation in HELOC underwriting, enhancing efficiency and borrower experience. Collaborate cross-functionally to streamline processes, leverage AI, and lead product strat...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $145K *

Lead the charge in strategic account management, driving growth and strengthening customer partnerships. Collaborate cross-functionally to align business objectives with customer needs while overseein...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.