Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $130K *

Transform developer experiences by designing intuitive growth-focused products. Collaborate with a dedicated team to enhance usability, streamline onboarding, and boost retention for impactful voice-d...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $169K *

Unlock your potential as you design and enhance go-to-market programs that drive sales productivity and revenue growth. Collaborate with cross-functional teams to translate strategy into actionable in...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Transportation

$177K - $224K *

Lead strategic customer relationships in aerospace and energy sectors, driving renewals and engineering engagements. Own key accounts, transition pricing models, and ensure customer success through te...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Champion data migration initiatives by leading analysis, strategy development, and execution. Collaborate with project teams to ensure quality and governance across large-scale projects, driving effic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Champion project success by leading clinical trials from initiation to closure, ensuring compliance with budgets, timelines, and regulations while fostering collaboration among stakeholders and team m...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Partner with us to deliver exceptional patient care as you collaborate with physicians, manage cases, and provide advanced nursing services, including examinations, diagnostics, and treatment plans in...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Elevate your sales career by driving enterprise accounts through consultative selling. Collaborate with marketing leaders, manage complex deals, and leverage a supportive team to achieve your targets...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $165K *

Elevate your career by developing and testing software modules while collaborating with cross-functional teams to ensure quality delivery and client satisfaction. Drive innovation through effective do...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $135K *

Tackle the full sales cycle by winning new logos and expanding accounts. Drive pipeline growth through outbound prospecting and inbound leads, while shaping go-to-market strategies in a dynamic, remot...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$46K - $122K *

Lead the charge in developing pricing strategies and financial models for PBM client contracts. Collaborate with sales and account teams to optimize revenue and profitability while presenting analyses...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$124K - $140K *

Lead data analytics initiatives by defining priorities and timelines to deliver actionable insights and research projects. Collaborate with cross-functional teams to enhance data-driven decision-makin...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$112K - $130K *

Champion the operational excellence of Dynamics 365 Customer Engagement, ensuring platform stability and usability. Collaborate across teams to enhance processes and drive continuous improvement in a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$300K - $350K *

Engage in a dynamic sales role, driving the full cycle from pipeline generation to closing six-figure deals in mid-market and enterprise cybersecurity. Contribute to go-to-market strategies and build...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $140K *

Join a team that's dedicated to designing and implementing resilient infrastructure solutions that enhance operational readiness and supportability while aligning with enterprise architecture standard...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $105K *

Lead the charge in enhancing quality assurance and performance oversight by analyzing requirements and deliverables, ensuring alignment with contractual standards, and driving process improvements for...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $185K *

Elevate product marketing strategies by driving awareness and adoption across diverse teams. Collaborate with Product, Sales, and Client Success to enhance market presence and create compelling messag...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$71K - $107K *

Champion sales growth by driving incremental volume and sustaining existing business with foodservice operators across diverse channels. Collaborate with teams to leverage data and build strong partne...

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$218K - $256K *

Lead the end-to-end execution of ML systems for identity verification, ensuring the integrity of millions of accounts through advanced models and cross-team collaboration, while mentoring engineers an...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Transform supply chain operations by leading teams, optimizing processes, and ensuring safety and efficiency in vehicle production. Drive continuous improvement and develop future leaders while managi...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Lead the charge in overseeing project financials and operations, mentoring teams, and ensuring profitability across multiple construction projects. Drive strategic planning and resource allocation whi...

1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$137K - $175K *

Lead the charge in driving advertising revenue by cultivating strong vendor relationships, leveraging data insights, and collaborating with cross-functional teams to deliver impactful media solutions...

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$137K - $175K *

Accelerate progress at a leading media firm by driving advertising revenue, cultivating client relationships, and leveraging data insights to deliver impactful marketing solutions across diverse vendo...

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$70K - $92K *

Elevate mental health care by providing evidence-based therapy via video sessions. Manage diverse client needs while utilizing innovative digital tools for enhanced outcomes. Collaborate with peers in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$155K - $185K *

Elevate your career by driving growth within enterprise accounts. Utilize a consultative approach to uncover opportunities, engage stakeholders, and close deals, all while collaborating with a dynamic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$201K - $239K *

Grow strategic relationships with global enterprise clients, driving EHS and ESG success. Leverage consultative selling to expand accounts, collaborate cross-functionally, and ensure exceptional custo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.