Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $133K *

Join a team that's building and leading a high-performing Business Development group. Drive prospecting strategies, enhance team performance, and collaborate with Sales and Marketing to accelerate pip...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Lead a dynamic team of travel therapy recruiters while driving personal production. Champion recruitment strategies, enhance team performance, and ensure alignment with client demands to achieve booki...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$88K - $105K *

Pioneer continuous improvement in supply planning operations, driving efficiency and governance. Leverage expertise in inventory optimization and Infor ERP systems to enhance processes and support ope...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $150K *

Unlock potential by driving hardware security assessments, improving client security postures, and delivering actionable insights. Collaborate with teams and engage directly with clients while enhanci...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Optimize integration processes by bridging technical gaps between systems. Collaborate with campus IT to ensure seamless data flows, troubleshoot issues, and enhance integration reliability for succes...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$190K - $267K *

Champion innovation by leading cross-functional teams to design and deliver scalable, high-performance infrastructure solutions that enhance reliability and efficiency across diverse applications and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$130K - $160K *

Join a team that's building from the ground up, shaping the engineering foundation and culture while collaborating closely with leadership to define and deliver innovative products...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$126K - $137K *

Champion innovative software solutions by developing and optimizing full-stack applications in the CAD/CAE domain, leveraging Java, Angular, and cloud technologies to enhance user experience and perfo...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Advance client security through strategic advisory and tailored solutions, leveraging deep cybersecurity expertise to mitigate risks and drive positive change. Collaborate with sales teams, maintainin...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Unlock potential by serving as a strategic security advisor, guiding clients through their cybersecurity challenges with tailored solutions while collaborating with sales teams and maintaining industr...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Strategize comprehensive cybersecurity solutions, influencing client security outcomes. Leverage technical expertise to bridge client needs and offering development, fostering robust relationships and...

Kansas City, MORemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$250K - $500K+*

Optimize and innovate software kernels for hardware integration, collaborating with ML Research and Hardware Engineering teams to enhance performance and efficiency in cutting-edge technology applicat...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$165K - $225K *

Elevate infrastructure capabilities by designing and implementing a unified platform that integrates bare-metal servers, storage, and networking for large-scale computation and AI workloads, ensuring...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $120K *

Support and enhance business development initiatives for Litigation and Labor & Employment Departments. Collaborate with senior managers and attorneys to drive client engagement, execute marketing str...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$100K - $120K *

Champion growth by owning the full sales cycle, educating clients, and driving custom part sourcing for hardware companies. Collaborate with a remote team to deliver exceptional service and build last...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$170K - $200K *

Transform customer experiences by providing technical expertise and solutions. Collaborate with sales and engineering teams to deliver impactful product demonstrations and address technical challenges...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $200K *

Join a team that's dedicated to advancing clinical research by leading operational aspects of trials, ensuring compliance with protocols and regulations, and fostering collaboration among stakeholders...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $145K *

Lead the charge in optimizing payroll integration operations, managing teams, and driving strategic alignment across functions. Elevate customer experience through data-driven insights and innovative...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$189K - $231K *

Innovate and shape the future of AI platforms as a Senior Engineer, designing and building critical subsystems for enterprise Kubernetes environments. Collaborate with customers and mentor engineers t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$96K - $120K *

Empower businesses by providing tailored banking solutions, driving client engagement, and achieving sales goals. Collaborate with branch teams to enhance service offerings and foster strong relations...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$187K - $281K *

Redefine market access strategies by leading payer engagement to enhance patient access to genomic testing. Collaborate cross-functionally to drive favorable coverage and reimbursement policies, ensur...

United StatesRemote

1 week ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$320K - $405K *

Transform the future of data center engineering by resolving on-site technical issues, collaborating with contractors, and ensuring project success through effective problem-solving and communication...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $160K *

Create impactful solutions as a Senior Product Engineer, owning projects from concept to delivery. Collaborate with a dynamic team, leveraging AI tools to enhance development while mentoring peers and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$80K - $85K *

Lead the charge in managing a skilled team of mechanics and technicians, ensuring high-quality maintenance and repair of heavy equipment while fostering a safe and efficient work environment...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$97K - $174K *

Accelerate patient care as a Nurse Practitioner in Maternal Fetal Medicine, managing complex pregnancies and collaborating with specialists to ensure comprehensive support for mothers and babies in an...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.