Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$110K - $130K *
Elevate product design by leading innovative initiatives, guiding cross-functional teams, and shaping user experiences from concept to delivery. Drive design excellence and foster a culture of feedbac...
Reposted today
Sales Development Manager - Attribute™
$110K - $130K *
Lead and scale a high-performing global SDR team, optimizing outbound strategies and driving pipeline through innovative coaching and performance tracking in a dynamic, fast-paced environment...
Reposted today
Director, Medical Writing - Market Access Promotional Agency
$117K - $165K *
Lead the charge in developing strategic medical content while collaborating cross-functionally and ensuring high standards of accuracy and clarity, influencing multiple therapeutic projects for a dive...
Reposted today
Senior Manager, Vendor Management
$110K - $130K *
Manage vendor intake and performance oversight, ensuring compliance and alignment with enterprise objectives while fostering strong vendor relationships and leading a team to drive operational excelle...
Today
VP, Infrastructure Engineering
$180K - $220K *
Lead the infrastructure engineering team to drive strategic initiatives, enhance developer productivity, and ensure reliability as the organization scales towards ambitious growth targets, including A...
Today
Senior AI Engineer (CCC Casualty / Claims Intelligence)
$180K - $225K *
Transform the future of auto claims by designing AI agents that enhance decision-making and streamline processes. Join a dynamic team to build innovative solutions that improve efficiency and accuracy...
Today
Senior Lead, Finance Business Partner
$147K - $273K *
Drive financial strategy for a leading K12 assessment business, partnering with senior leadership to shape commercial decisions, manage risks, and enhance performance across diverse business models wh...
Today
Principal, Knowledge & AI Transformation
$77K - $104K *
Lead transformative knowledge strategies that enhance customer experiences and drive AI integration across multiple functions. Collaborate with teams to ensure knowledge is accurate, discoverable, and...
Today
$120K - $140K *
Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...
Reposted today
Senior Product Marketing Manager, AI
$120K - $145K *
Engage with cross-functional teams to drive AI security product marketing initiatives, focusing on buyer insights, competitive analysis, and effective sales enablement. Collaborate on launches and con...
Reposted today
$145K - $185K *
Join a dynamic team to drive innovation in HELOC underwriting, enhancing efficiency and borrower experience. Collaborate cross-functionally to streamline processes, leverage AI, and lead product strat...
Today
$135K - $145K *
Lead the charge in strategic account management, driving growth and strengthening customer partnerships. Collaborate cross-functionally to align business objectives with customer needs while overseein...
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$82K - $113K *
Join a team that's dedicated to innovative product design and development. Collaborate with cross-functional teams, lead projects, and ensure compliance with industry standards while utilizing your en...
Reposted today
Software Engineer II - Cloud-Native Agent Harness (Mecatl)
$157K - $192K *
Develop and enhance a cloud-native agent harness, ensuring secure, reliable, and efficient operations. Collaborate with a dynamic team to deliver features, fix bugs, and innovate using AI throughout t...
Today
Senior Underwriter (Premier Construction)
$94K - $117K *
Unlock your potential as a key underwriter, evaluating complex insurance applications and guiding risk assessment. Collaborate with a dynamic team to enhance underwriting practices while fostering rel...
Today
Senior Technical Consultant, Integrations - Higher Education & Nonprofit
$111K - $197K *
Champion integration solutions by leading projects, conducting discovery sessions, and implementing complex integrations for clients in Higher Education and Nonprofit sectors. Drive results and ensure...
Today
Sales Director, Mid-Market & SMB (Gracenote Division)
$125K - $150K *
Accelerate growth by leading commercial strategy and sales for Mid-Market & SMB segments. Drive revenue, manage KPIs, and collaborate cross-functionally to enhance client satisfaction and market prese...
Today
$130K - $160K *
Deliver high-quality telemedicine care to complex patients, focusing on symptom management and improving outcomes. Collaborate with a multidisciplinary team to enhance patient experiences and facilita...
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AI Engineer (Superhuman Mail) - US
$135K - $160K *
Champion innovation in AI engineering by building intelligent systems that enhance productivity and streamline workflows, enabling teams to deliver exceptional user experiences and drive the future of...
Today
$140K - $160K *
Design and enhance intelligent AI systems for K-12 assessment, collaborating across disciplines to create reliable, evaluative solutions that integrate seamlessly into educational frameworks and suppo...
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$95K - $115K *
Transform the BCP business by leading product strategies, optimizing sales performance, and enhancing customer engagement. Drive growth through analytics, competitive insights, and effective program m...
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Incident Management Program Lead
$123K - $155K *
Lead the charge in enhancing incident management practices across global data centers. Collaborate with teams to develop standards, improve processes, and drive operational excellence, ensuring effect...
Reposted today
Founding Enterprise Account Executive, Health Plans
$270K - $340K *
Unlock potential by driving sales for innovative healthcare compliance solutions. Own the full sales cycle with health plans, transforming initial conversations into lasting partnerships while shaping...
Today
$100K - $120K *
Manage the full sales cycle for mid-sized jurisdictions, focusing on pipeline growth and relationship building. Drive revenue through prospecting, closing deals, and collaborating with cross-functiona...
Today
Senior Director, Field Operations
$229K - $330K *
Join us to redefine revenue operations by leading a dynamic team that transforms GTM strategies into actionable insights, ensuring scalable success across diverse market segments and driving AI-enhanc...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.