Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$110K - $130K *

Elevate product design by leading innovative initiatives, guiding cross-functional teams, and shaping user experiences from concept to delivery. Drive design excellence and foster a culture of feedbac...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead and scale a high-performing global SDR team, optimizing outbound strategies and driving pipeline through innovative coaching and performance tracking in a dynamic, fast-paced environment...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$117K - $165K *

Lead the charge in developing strategic medical content while collaborating cross-functionally and ensuring high standards of accuracy and clarity, influencing multiple therapeutic projects for a dive...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Manage vendor intake and performance oversight, ensuring compliance and alignment with enterprise objectives while fostering strong vendor relationships and leading a team to drive operational excelle...

Missouri, USRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Lead the infrastructure engineering team to drive strategic initiatives, enhance developer productivity, and ensure reliability as the organization scales towards ambitious growth targets, including A...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$180K - $225K *

Transform the future of auto claims by designing AI agents that enhance decision-making and streamline processes. Join a dynamic team to build innovative solutions that improve efficiency and accuracy...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$147K - $273K *

Drive financial strategy for a leading K12 assessment business, partnering with senior leadership to shape commercial decisions, manage risks, and enhance performance across diverse business models wh...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$77K - $104K *

Lead transformative knowledge strategies that enhance customer experiences and drive AI integration across multiple functions. Collaborate with teams to ensure knowledge is accurate, discoverable, and...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$120K - $140K *

Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Engage with cross-functional teams to drive AI security product marketing initiatives, focusing on buyer insights, competitive analysis, and effective sales enablement. Collaborate on launches and con...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$145K - $185K *

Join a dynamic team to drive innovation in HELOC underwriting, enhancing efficiency and borrower experience. Collaborate cross-functionally to streamline processes, leverage AI, and lead product strat...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $145K *

Lead the charge in strategic account management, driving growth and strengthening customer partnerships. Collaborate cross-functionally to align business objectives with customer needs while overseein...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$82K - $113K *

Join a team that's dedicated to innovative product design and development. Collaborate with cross-functional teams, lead projects, and ensure compliance with industry standards while utilizing your en...

Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$157K - $192K *

Develop and enhance a cloud-native agent harness, ensuring secure, reliable, and efficient operations. Collaborate with a dynamic team to deliver features, fix bugs, and innovate using AI throughout t...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$94K - $117K *

Unlock your potential as a key underwriter, evaluating complex insurance applications and guiding risk assessment. Collaborate with a dynamic team to enhance underwriting practices while fostering rel...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$111K - $197K *

Champion integration solutions by leading projects, conducting discovery sessions, and implementing complex integrations for clients in Higher Education and Nonprofit sectors. Drive results and ensure...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$125K - $150K *

Accelerate growth by leading commercial strategy and sales for Mid-Market & SMB segments. Drive revenue, manage KPIs, and collaborate cross-functionally to enhance client satisfaction and market prese...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$130K - $160K *

Deliver high-quality telemedicine care to complex patients, focusing on symptom management and improving outcomes. Collaborate with a multidisciplinary team to enhance patient experiences and facilita...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Champion innovation in AI engineering by building intelligent systems that enhance productivity and streamline workflows, enabling teams to deliver exceptional user experiences and drive the future of...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$140K - $160K *

Design and enhance intelligent AI systems for K-12 assessment, collaborating across disciplines to create reliable, evaluative solutions that integrate seamlessly into educational frameworks and suppo...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Transform the BCP business by leading product strategies, optimizing sales performance, and enhancing customer engagement. Drive growth through analytics, competitive insights, and effective program m...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$123K - $155K *

Lead the charge in enhancing incident management practices across global data centers. Collaborate with teams to develop standards, improve processes, and drive operational excellence, ensuring effect...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$270K - $340K *

Unlock potential by driving sales for innovative healthcare compliance solutions. Own the full sales cycle with health plans, transforming initial conversations into lasting partnerships while shaping...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Manage the full sales cycle for mid-sized jurisdictions, focusing on pipeline growth and relationship building. Drive revenue through prospecting, closing deals, and collaborating with cross-functiona...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$229K - $330K *

Join us to redefine revenue operations by leading a dynamic team that transforms GTM strategies into actionable insights, ensuring scalable success across diverse market segments and driving AI-enhanc...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.