Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $95K *

Shape the future of neurodiverse care by leading clinical services and programming for youth with developmental differences, ensuring high standards and collaborative practices across inpatient and re...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$104K - $174K *

Unlock your potential by developing and implementing advanced analytics and AI solutions. Collaborate with cross-functional teams to translate complex data into actionable insights, driving business a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$73K - $102K *

Unlock potential by developing and deploying Python applications for IT operations, data management, and cloud solutions. Collaborate on data engineering and machine learning projects while adhering t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$122K - $155K *

Unlock potential by bridging business needs with technology solutions in the Microsoft Power Platform. Collaborate with stakeholders to deliver user-friendly, secure, and scalable digital solutions th...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$72K - $118K *

Drive customer-focused utility distribution design projects from inception to completion, ensuring compliance and efficiency while collaborating with various stakeholders to enhance service delivery a...

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$100K - $120K *

Optimize patient care by processing prescriptions, monitoring therapies, and educating patients. Collaborate with a dedicated team to ensure effective pharmacy operations while supervising support sta...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$168K - $310K *

Lead the charge in designing cutting-edge SRAM circuits for next-gen AI chips, optimizing performance and power while collaborating with cross-functional teams to deliver innovative memory solutions a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$104K - $114K *

Elevate patient care by collaborating with a dedicated team to deliver personalized dental hygiene services. Enjoy flexible scheduling, advanced technology, and ongoing professional development in a s...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by building strategic relationships with athletic associations, leading RFPs, and driving school subscriptions. Own the growth strategy in new states with autonomy to shape processes...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$145K - $175K *

Lead large conceptual EPC bids, providing strategic oversight and mentorship to estimating teams. Drive proposal strategies, risk management, and ensure compliance with industry standards while managi...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $200K *

Transform clinical research by leading operational oversight of studies, ensuring compliance with protocols and regulations. Collaborate with teams to drive site feasibility, manage budgets, and enhan...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Champion new business opportunities in the diagnostic sales sector, driving growth in non-acute care markets. Achieve sales quotas, foster client relationships, and implement innovative technologies t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$220K - $300K *

Shape the future of financial strategy by leading comprehensive reporting, planning, and analysis. Collaborate with cross-functional teams to enhance decision-making and drive performance, while ensur...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$111K - $130K *

Join a team that's transforming healthcare delivery through innovative product management. You'll oversee the Lighthouse platform, enhancing care team efficiency while collaborating with cross-functio...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $210K *

Transform Oracle Cloud ERP solutions by leading technical architecture and ensuring quality. Collaborate with teams to drive design decisions and deliver successful implementations while mentoring oth...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $150K *

Shape the future of music sales by driving territory strategy and building strong dealer relationships. Achieve sales targets across a diverse brand portfolio while collaborating with cross-functional...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$228K - $262K *

Grow your career with a strategic role focused on acquiring enterprise clients. Engage with C-level executives, manage complex sales cycles, and drive new business through consultative selling and rel...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$159K - $230K *

Drive the efficient delivery of complex data center projects by leading planning and scheduling efforts across multiple campuses, ensuring timely execution and alignment with business objectives while...

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Transform talent acquisition by leading innovative recruitment strategies, ensuring a seamless candidate experience, and collaborating with stakeholders to deliver diverse talent pools that meet uniqu...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$200K - $250K *

Champion product security initiatives by leading a skilled team, architecting compliance frameworks, and managing incident response to enhance trust across all products and stakeholders...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$135K - $196K *

Unlock potential by shaping the demo experience through innovative tooling and infrastructure. Collaborate across teams to enhance product communication and drive secure access solutions, all while le...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $190K *

Lead and inspire a high-performing Solutions Engineering team, driving technical pre-sales excellence and shaping customer engagement with our AI-powered identity security platform to enhance security...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$94K - $266K *

Lead the successful delivery of complex field service technology programs, focusing on client relationships, project management, and strategic execution. Collaborate with teams to enhance service expe...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$80K - $100K *

Unlock your potential as you manage complex healthcare accounts, driving adoption and retention through strategic partnerships. Forge deep relationships, ensure executive satisfaction, and identify gr...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Optimize data management processes for large government acquisitions, ensuring effective communication between teams and shipyards. Lead document management, maintain schedules, and enhance data quali...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.