Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$72K - $90K *

Shape the future of business travel by managing bid responses and collaborating with teams to ensure high-quality proposals that meet client needs and company standards. Engage with subject matter exp...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$82K - $150K *

Drive growth by aggressively prospecting and converting new dental accounts while expanding existing relationships. Utilize a hunter mentality to identify opportunities and position value-oriented imp...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's driving innovation by leading cross-functional programs that enhance business engagement and operational efficiency, bridging technology and strategy to support growth in a dynamic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $175K *

Drive financial operations and internal controls while leading a remote accounting team. Oversee month-end closes, technical accounting, and ERP transformations to enhance operational efficiency and e...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$113K - $127K *

Transform employee relations by leading investigations, resolving disputes, and advising on best practices. Collaborate with leaders to enhance workplace culture and ensure compliance, driving strateg...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Transform client relationships by leading strategic marketing efforts across eCommerce, retail, and DTC strategies, while ensuring performance aligns with business objectives and driving measurable gr...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Lead innovative marketing campaigns for fashion clients by leveraging digital strategies, optimizing cross-channel efforts, and guiding account teams to drive performance and business growth through t...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Lead a dynamic engineering team to innovate and deliver backend solutions, enhancing our technology's reach. Engage hands-on in coding and architecture while mentoring others, ensuring high-quality so...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Transportation

$79K - $127K *

Engineer robust solutions for Power Delivery projects, ensuring safety and efficiency through hands-on execution, troubleshooting, and training to enhance system performance and drive customer satisfa...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$165K - $180K *

Transform your career by driving new customer acquisition in healthcare. Leverage your expertise to build C-suite relationships and lead complex sales processes, contributing to the growth of a dynami...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Technical Services

$80K - $92K *

Drive the resolution of technical support escalations as a key Tier 2 expert, leveraging your skills to troubleshoot issues, foster collaboration within teams, and enhance workflows in a dynamic envir...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Technical Services

$160K - $190K *

Transform data-driven marketing strategies by leading quality assurance initiatives, ensuring compliance, and leveraging analytics to enhance decision-making and process improvements across cross-func...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform vulnerability detection by leveraging innovative technology and research. Join a team dedicated to crafting detection logic to identify critical vulnerabilities, ensuring clients stay one st...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Optimize cloud operations by managing Azure and AWS environments, ensuring reliability, performance, and security. Leverage modern IaC and AI tools to enhance workload efficiency and operational excel...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$77K - $202K *

Elevate your career by driving operational excellence in manufacturing. Analyze processes, identify bottlenecks, and implement strategies that enhance product development, reduce costs, and improve qu...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$77K - $202K *

Advance manufacturing operations by analyzing processes, identifying bottlenecks, and implementing strategies for quality improvement and cost reduction. Build client relationships, mentor junior staf...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$82K - $137K *

Transform business insights into actionable data solutions by collaborating with stakeholders, analyzing data quality, and ensuring effective integration of analytical products to drive operational ef...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$78K - $93K *

Engage with local businesses to provide tailored health benefit solutions. Build lasting relationships while enjoying comprehensive training and mentorship. Ideal for motivated individuals seeking gro...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$165K - $198K *

Join a team that's dedicated to transforming rare disease treatment through strategic account management and collaboration. Drive sales performance while educating healthcare professionals and ensurin...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Accelerate progress at connecting communities with reliable telecommunication services. Engage directly with customers to drive sales and satisfaction while achieving monthly targets in a dynamic outd...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Manage impactful infrastructure projects by providing technical direction, mentoring staff, and ensuring project success through effective supervision and client relationship management in the Constru...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $100K *

Lead the charge in connecting communities with high-speed telecommunication services through face-to-face sales. Drive customer satisfaction and contribute to growth by tailoring solutions to meet ind...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$112K - $135K *

Elevate your career by designing and implementing cloud infrastructure solutions in Azure. Collaborate with teams to automate deployments, optimize CI/CD pipelines, and leverage AI tools for enhanced...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$167K - $176K *

Shape the future of design operations by driving program execution, leveraging AI for efficiency, and managing cross-functional partnerships to enhance creative workflows and deliver impactful design...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$94K - $266K *

Architect enterprise-scale Data 360 and AI solutions for Financial Services, leading design sessions and ensuring scalable architecture across Banking, Capital Markets, and Insurance while mentoring t...

1 week ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.