Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior SOX Manager - Business Processes
$185K - $195K *
Reimagine SOX compliance by leading business process assessments, integrating controls, and collaborating with cross-functional teams to enhance financial transparency and accountability in reporting...
Reposted 1 week ago
Director, AI Solutions Strategy & Planning
$206K - $261K *
Accelerate the commercialization of AI-driven solutions by leading strategy and planning efforts. Collaborate cross-functionally to define go-to-market frameworks, enhance retailer experiences, and dr...
Reposted 1 week ago
Senior Engineering Manager, Core Picking
$265K - $279K *
Empower your career by leading the Enterprise Fulfillment engineering team, setting technical vision, owning engineering roadmaps, and fostering a culture of excellence with 10+ engineers while collab...
Reposted 1 week ago
Principal Engineer, Data Platform
$246K - $339K *
Champion the evolution of our Data Platform by architecting scalable solutions for large-scale data migrations, empowering teams with self-service storage capabilities, and ensuring reliability across...
1 week ago
GCC/GBS Americas Sales Advisory Manager/Sr manager
$94K - $266K *
Accelerate success as a dedicated specialist driving GCC pursuits across the Americas, ensuring high-quality proposal content, collaborating with deal teams, and enhancing win strategies throughout th...
Reposted 1 week ago
$120K - $180K *
Optimize sourcing strategies for electronic components, fostering supplier partnerships and ensuring reliable access to critical materials. Collaborate across teams to enhance procurement processes an...
1 week ago
Staff Software Engineer, Developer Experience
$193K - $309K *
Pioneer innovative developer experiences by setting technical direction and enhancing workflows. Collaborate across teams to design solutions that empower engineers, leveraging AI to redefine software...
Reposted 1 week ago
Principal TA Systems Architect
$128K - $205K *
Elevate your career by owning the TA tech stack, driving integrations, and enhancing system efficiency. Collaborate with cross-functional teams to optimize processes and lead vendor relationships, all...
Reposted 1 week ago
Territory Account Executive, Retail - West St. Louis, MO
$115K - $185K *
Contribute to the growth of our Retail platform by building relationships and signing new accounts in convenience stores and grocery chains. Use your sales expertise and consultative approach to creat...
Reposted 1 week ago
$230K - $368K *
Shape the future of high-scale SaaS solutions by leading architectural design, guiding teams, and driving impactful software strategies in a collaborative environment that values innovation and mentor...
Reposted 1 week ago
Therapy Development Specialist, Phoenix, AZ or Las Vegas, NV
$100K - $150K *
Collaborate with healthcare professionals to enhance therapy awareness and optimize care pathways for patients with venous thromboembolism. Drive education and program development initiatives across a...
1 week ago
Director, Strategic Account Development - Lockheed Martin
$150K - $180K *
Lead the charge in driving new business for the Aerospace & Defense sector, collaborating with cross-functional teams to capture high-value opportunities and establish executive relationships, ensurin...
1 week ago
$90K - $110K *
Unlock potential by leading the functional support and improvement of business systems for Legal, Procurement, Safety, and Environmental teams, ensuring effective use and resolution of issues while en...
1 week ago
$180K - $220K *
Drive excellence in dermatology by managing patient care, conducting consultations, and collaborating with healthcare teams. Engage in clinical, administrative, and educational activities to enhance p...
1 week ago
$81K - $122K *
Contribute to financial analysis and reporting, supporting strategic decision-making across departments. Collaborate with stakeholders to enhance budgeting, forecasting, and data management processes...
1 week ago
Performance Marketing & Marketing Operations Manager (United States)
$95K - $115K *
Drive paid media performance and optimize marketing operations to enhance growth. Manage campaign execution, budget allocation, and HubSpot systems, ensuring effective lead generation and data-driven...
1 week ago
Workplace Services LeadWest/Canada
$95K - $115K *
Champion workplace excellence by leading stakeholder relationships and optimizing service delivery across a diverse portfolio. Ensure alignment with strategic goals, financial stewardship, and operati...
1 week ago
Associate Director or Director, Clinical Outsourcing
$175K - $250K *
Lead the charge in executing clinical outsourcing strategies across oncology trials, managing vendor relationships, contract negotiations, and financial oversight to ensure optimal performance and com...
Reposted 1 week ago
$85K - $105K *
Join a team that's dedicated to driving sales success by developing strong client relationships and identifying new business opportunities in a competitive environment. Leverage your skills to deliver...
1 week ago
$120K - $145K *
Champion quality by designing and leading automated testing strategies for diverse products. Collaborate with engineers to enhance test frameworks, mentor teams, and ensure high standards across platf...
1 week ago
Family Nurse Practitioner - Neosho
$90K - $110K *
Unlock potential by delivering comprehensive primary care services, utilizing your advanced practice nursing expertise to assess, diagnose, and treat patients independently while collaborating with a...
1 week ago
Crypto Reconciliation Specialist
$80K - $96K *
Join a team that's redefining crypto reconciliation by managing complex client cases from start to finish. Utilize cutting-edge tools to ensure accurate tax reporting and provide exceptional client su...
1 week ago
Regional Congress Account Manager
$75K - $110K *
Transform client engagement in a dynamic, detail-oriented environment. Collaborate with cross-functional teams to ensure program success and elevate customer experiences in the Life Sciences sector. D...
1 week ago
Executive Director - Office of the President
$125K - $150K *
Champion strategic initiatives and enhance institutional effectiveness by providing executive-level support to the President, facilitating collaboration across campuses, and driving accountability in...
1 week ago
$145K *
Drive significant growth by managing the entire sales cycle for mid-market nonprofit clients, nurturing relationships to unlock their potential and optimize the use of our innovative solutions, while...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.