Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$185K - $195K *

Reimagine SOX compliance by leading business process assessments, integrating controls, and collaborating with cross-functional teams to enhance financial transparency and accountability in reporting...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$206K - $261K *

Accelerate the commercialization of AI-driven solutions by leading strategy and planning efforts. Collaborate cross-functionally to define go-to-market frameworks, enhance retailer experiences, and dr...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$265K - $279K *

Empower your career by leading the Enterprise Fulfillment engineering team, setting technical vision, owning engineering roadmaps, and fostering a culture of excellence with 10+ engineers while collab...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$246K - $339K *

Champion the evolution of our Data Platform by architecting scalable solutions for large-scale data migrations, empowering teams with self-service storage capabilities, and ensuring reliability across...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$94K - $266K *

Accelerate success as a dedicated specialist driving GCC pursuits across the Americas, ensuring high-quality proposal content, collaborating with deal teams, and enhancing win strategies throughout th...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $180K *

Optimize sourcing strategies for electronic components, fostering supplier partnerships and ensuring reliable access to critical materials. Collaborate across teams to enhance procurement processes an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$193K - $309K *

Pioneer innovative developer experiences by setting technical direction and enhancing workflows. Collaborate across teams to design solutions that empower engineers, leveraging AI to redefine software...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$128K - $205K *

Elevate your career by owning the TA tech stack, driving integrations, and enhancing system efficiency. Collaborate with cross-functional teams to optimize processes and lead vendor relationships, all...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $185K *

Contribute to the growth of our Retail platform by building relationships and signing new accounts in convenience stores and grocery chains. Use your sales expertise and consultative approach to creat...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$230K - $368K *

Shape the future of high-scale SaaS solutions by leading architectural design, guiding teams, and driving impactful software strategies in a collaborative environment that values innovation and mentor...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $150K *

Collaborate with healthcare professionals to enhance therapy awareness and optimize care pathways for patients with venous thromboembolism. Drive education and program development initiatives across a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in driving new business for the Aerospace & Defense sector, collaborating with cross-functional teams to capture high-value opportunities and establish executive relationships, ensurin...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Unlock potential by leading the functional support and improvement of business systems for Legal, Procurement, Safety, and Environmental teams, ensuring effective use and resolution of issues while en...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$180K - $220K *

Drive excellence in dermatology by managing patient care, conducting consultations, and collaborating with healthcare teams. Engage in clinical, administrative, and educational activities to enhance p...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$81K - $122K *

Contribute to financial analysis and reporting, supporting strategic decision-making across departments. Collaborate with stakeholders to enhance budgeting, forecasting, and data management processes...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Drive paid media performance and optimize marketing operations to enhance growth. Manage campaign execution, budget allocation, and HubSpot systems, ensuring effective lead generation and data-driven...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Champion workplace excellence by leading stakeholder relationships and optimizing service delivery across a diverse portfolio. Ensure alignment with strategic goals, financial stewardship, and operati...

1 week ago

  •   5 - 7 years exp.  •   Media

$175K - $250K *

Lead the charge in executing clinical outsourcing strategies across oncology trials, managing vendor relationships, contract negotiations, and financial oversight to ensure optimal performance and com...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $105K *

Join a team that's dedicated to driving sales success by developing strong client relationships and identifying new business opportunities in a competitive environment. Leverage your skills to deliver...

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$120K - $145K *

Champion quality by designing and leading automated testing strategies for diverse products. Collaborate with engineers to enhance test frameworks, mentor teams, and ensure high standards across platf...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $110K *

Unlock potential by delivering comprehensive primary care services, utilizing your advanced practice nursing expertise to assess, diagnose, and treat patients independently while collaborating with a...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $96K *

Join a team that's redefining crypto reconciliation by managing complex client cases from start to finish. Utilize cutting-edge tools to ensure accurate tax reporting and provide exceptional client su...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $110K *

Transform client engagement in a dynamic, detail-oriented environment. Collaborate with cross-functional teams to ensure program success and elevate customer experiences in the Life Sciences sector. D...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Transportation

$125K - $150K *

Champion strategic initiatives and enhance institutional effectiveness by providing executive-level support to the President, facilitating collaboration across campuses, and driving accountability in...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$145K *

Drive significant growth by managing the entire sales cycle for mid-market nonprofit clients, nurturing relationships to unlock their potential and optimize the use of our innovative solutions, while...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.